Thymosin Alpha-1 5mg

Why Choose CellPeptides’ Thymosin Alpha-1?

The integrity of your research depends on the quality of your peptides — and immune studies require nothing less than perfection. Impurities can skew cytokine assays, mask therapeutic potential, or worse, put years of scientific work at risk. CellPeptides delivers pharma-grade Tα1 that researchers can confidently use to push their studies forward.

Our Thymosin Alpha-1 is:

• Made to ≥99% purity — endotoxin-free Tα1 with intact bioactivity.
• Third-party lab tested — read our latest COAs from independent labs to check purity and composition.
• Synthesized to replicate the exact 28-amino acid sequence (C129H215N33O55) of endogenous Tα1.
• Shipped in liophilized powder to preserve integrity, and of course — discreet packaging.

CellPeptides ships globally and quickly. Packages are insured and have tracking codes. Our customer support team is always on the clock to answer your questions about ordering or peptide research. Your search for a reliable research and scientific company for all your peptide sourcing? It ends with CellPeptides — so you can start your research right now.

How Does Thymosin Alpha-1 Work?

Thymosin Alpha-1 isn’t another immune booster. This 28-amino acid peptide builds a smarter, more effective immune response — and in four different ways.

Tα1 activates dendritic cells by acting on toll-like receptors (especially TLR9 and TLR2), which scout the body for threats. That improves pathogen detection and sets the body up for a more effective response.

It helps to make sure that T-cells mature on track, pushes the immune system toward a Th1-biased response that makes it fight threats (cancer, viruses, bacteria…) faster and more efficiently, and it brings the immune system back into balance after a period of intense stress. Its success in restoring immune homeostasis means it’s no surprise that Thymosin Alpha-1 is a powerful immune support system after chemotherapy and for patients with chronic viral infections.

Thymosin Alpha-1 is clinically used to support patients with cancer and chronic hepatitis in many parts of the world — especially in Europe. The peptide has exciting research potential far beyond those established applications, however.

Thymosin Alpha-1 Research: Documented Effects and Emerging Applications

Research into the potential applications of Thymosin Alpha-1 has been emerging since the peptide was first described in the 1970s — when it became the first peptide from Thymosin Fraction 5 to be fully sequenced and synthesized. Thymosin Alpha-1 is, primarily, an immunomodulator. Most research has focused on that area.

Curious what else research into the practical benefits of Thymosin Alpha-1 has touched on? This section is for you — and you’ll find links to further reading below to continue your investigations.

Thymosin Alpha-1 in Cancer Immunotherapy

Chemotherapy is life-saving, but it destroys the immune system along with cancer cells — and rebuilding it takes time, time during which patients are uniquely vulnerable. Thymosin Alpha-1 speeds this difficult process up. That’s not all it does, though. Studies have also discovered that  Thymosin Alpha-1 makes cancer treatment more effective by putting the body in a stronger position to fight residual cancer cells. [1]

It does not, to be clear, have potential as a stand-alone treatment for cancer. As Thymosin Alpha-1 builds a stronger body, a more resilient body, after treatment, however, research points to improved survival rates and a faster return to health.

Thymosin Alpha-1 Research and Autoimmune Diseases

We already mentioned that Thymosin Alpha-1 doesn’t simply stimulate the immune system, but actually regulates it — which means it also has interesting applications for autoimmune diseases, as contradictory as this looks to be at first glance. Early research (and this area of investigation is still in its infancy!) hints at the potential to balance the Th1/Th2 immune axis and boost the production of regulatory T-cells. [2]

So far, studies have looked at the possibility that Thymosin Alpha-1 might restore that Th1/Th2 balance in rheumatoid arthritis [3] and reduce multiple sclerosis flareups [4].

Immune Aging and Thymosin Alpha-1 in Longevity Research

The thymus, from which Thymosin Alpha-1 was isolated, gradually shrinks with age — and with that shrinkage, immune function also declines. [5] What if Thymosin Alpha-1 could slow that decline? Research determined to find the answer to that question is in progress. It may open the door for better resilience in the face of pathogens with age, and this makes Tα1 a worthwhile peptide for researchers studying longevity.

Thymosin Alpha-1 in Sepsis Research

Sepsis is a life-threatening reaction to systemic infections that leads to “immunoparalysis” — that is, it causes a deep state of immunosuppression. It’s immediately apparent how a powerful immune regulator like Thymosin Alpha-1 might be able to come in and fix that dysregulation. Indeed, research has already looked at this [6]. While there’s more work to be done in that area, results show a reduced risk of death from sepsis.

Exciting Future Applications

Beyond the areas where Thymosin Alpha-1 has already been widely studied, glimpses of other potential benefits are also emerging. One of them is in the reduction of viral loads in COVID-19 patients — and reduced fatigue among people with “long COVID.” [7] Another is possible anti-depressive effects, specifically for people with weak immune systems [8].

Who Might Consider Thymosin Alpha-1?

The clinical studies conducted to date show that Thymosin Alpha-1 has a lot of promise, but the research continues. The potential of Tα1 is most interesting to researchers studying adjunct therapy for cancer, to virologists looking at chronic infection management, to autoimmune investigators hoping to discover alternatives to blunt-force immunosuppression, and to longevity researchers.

Tα1 is a smart answer to the broad-acting immune boosters and suppressants — a more targeted way to signal the body to bring itself back into balance. The potential? Let’s just say that existing research has likely scratched no more than the surface. What direction will your studies take?

Common Dosing Protocols for Thymosin Alpha-1 In-vitro Research Setting

Thanks to an impressive body of research, dosing protocols for Thymosin Alpha-1 are already well-established — although the dose depends on the goal of the research.

Most commonly, researchers recommend a starting dose of 0.1 to 0.5 mg per dose. This dose assesses tolerance in your model and establishes a baseline immune response — even microgram variations can and do impact effects, so gradual upward titration is recommended.

The standard research dosing is 1 to 3 mg per dose. That is, 1 mg for chronic low-grade inflammation studies, 1.5 to 2 mg for oncology research, and 3 mg for acute infection. Daily dosing is used for acute challenges, while twice-weekly dosing is more common for chronic conditions.

To reconstitute:

• Add 1 mL bacteriostatic water to 5 mg lyophilized Thymosin Alpha-1.
• Inject BAC water into the vial and swirl until it is fully dissolved.
• Stable in the fridge for 30-60 days at 2 to 8°C..

Follow lab protocols; use alcohol on vial tops and administration sites and low-dead-space syringes for ≤0.5 mg doses. Avoid with concurrent immunosuppressants such as cyclosporine. Keep careful lab logs.

FAQs

What are the main benefits of Thymosin Alpha-1?

Above all, it’s a powerful immunomodulator. Well-documented effects of Thymosin Alpha-1 include improved response to checkpoint inhibitors in cancer treatment, infection defense, better immune balance overall, and better defense against the age-related decline seen in the immune system.

What are the side effects of Thymosin Alpha-1?

Participants in most studies tolerate Thymosin Alpha-1 well, but passing fatigue and redness around the injection site are possible. No serious side effects have been documented, but contraindications exist and should be kept in mind.

Is Thymosin Alpha-1 a natural peptide?

It’s a 28-amino acid peptide that was initially isolated from the thymus. The synthetic version that is used in research settings (and available to buy from CellPeptides) is identical to the natural peptide — a long way to say “yes.”

What happens when you have too little Thymosin?

Deficiencies in Thymosin Alpha-1 weaken the immune system. They are associated with infections, low T-cell counts, chronic inflammation, and poor response to vaccines.

Can Thymosin Alpha-1 be taken orally?

No, because stomach acid destroys Thymosin Alpha-1. Research uses subQ, intranasal, or IV delivery.

DISCLAIMER:

Our peptides can be used solely for in vitro experiments and cannot be:

• Used in clinical trials involving humans
• Administered to humans as part of an experiment or investigation
• Supplied to another party for human investigational use

Scientific References

1. https://www.sciencedirect.com/science/article/abs/pii/S156757692300067X
2. https://academic.oup.com/cei/article/186/1/39/6412061
3. https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1756-185X.2011.01652.x
4. https://journals.sagepub.com/doi/abs/10.1177/1352458517695892
5. https://www.mdpi.com/1422-0067/25/2/1088
6. https://www.sciencedirect.com/science/article/pii/S1201971214017500
7. https://www.sciencedirect.com/science/article/pii/S1567576922010694
8. https://www.sciencedirect.com/science/article/pii/S2666354624002126