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Most people have never even heard of the thymus gland, but this specialized immune system organ is both the first to age and one we can’t afford to lose. Slowing age-related decline with topical treatments is one thing. Resetting the system that defends against it — the thymus — is another.
Thymalin, a polypeptide complex, might be the closest it gets. Russian scientist Professor Vladimir Khavinson discovered and studied Thymalin for decades while figuring out how the thymus impacts longevity. His team found something amazing. Mice treated with Thymalin saw a 30 percent lifespan extension and had dramatically lower rates of age-related disease.
Thymalin has research potential in anti-aging, heart health, and cancer therapy — reverse immune aging without touching stem cell therapies, fight the low-grade inflammation driving heart disease, and restore the immune system’s vigilance against precancerous cells.
The potential? Thymalin adds years — healthy years — in research models.
Thymalin is a bioregulator backed by decades of studies — but your research results depend on getting the precise formulation Professor Khavinson used in his longevity investigations. CellPeptides guarantees authenticity. We:
CellPeptides offers fast global shipping with secure and temperature-controlled packaging. We accept payment by credit card and wire transfer, but also cryptocurrency — and our support team is always available to answer your questions about peptide research or ordering. We’re an EU-based research company that delivers with superb-efficiency.
Age brings vulnerability — to infection, to cancer, and to general decline. Professor Khavinson’s research found an important piece of the puzzle explaining why. Thymalin restores the immune system (especially T-cell production) to more youthful levels.
This polypeptide complex, that is, collection of active peptides that mimic those the thymus makes itself, has been associated with longer lifespans in animal models because it “reprograms” the immune system. Thymalin renews the thymic function of making the naive T-cells without which the body cannot fight cancer and infections effectively.
It slashes vascular inflammation, long linked to atherosclerosis, and research suggests that it might guard neurons against the effects of oxidative stress. Thymalin corrects circadian rhythm dysfunction, one of the effects of aging, through its effects on thymus-pineal communication.
Studies show treated rodent models maintain youthful activity levels, coat quality, and organ function late into life. Khavinson’s models outlived their expected lifespans. More than that, they stayed healthier for longer.
Thymalin research has been extensive. It’s spanned decades. Given Professor Khavinson’s focus (longevity), it’s no surprise that much of it has focused on living well into old age. The impact Thymalin has on immune functioning is also well-studied, especially in Russia — where doctors routinely prescribe it to patients with compromised immune systems.
Other potential applications lie beyond those two most studied areas, though, and they’re equally interesting to researchers.
Cancer treatments are life-saving, but they devastate the immune system. Thymalin has been studied and used to help patients who’ve undergone chemotherapy get their T-cell counts back up more quickly. [1] That, in turn, lowers infection risk in this vulnerable population.
The use cases go further than adjunct therapy for cancer, however, because exciting studies have looked at the potential for Thymalin to impact immune functioning in both acute and chronic infections. Applications range from chronic hepatitis to tuberculosis, and from bronchitis to COVID-19. [2] Research has had promising results, but the benefits of Thymalin aren’t confined to the lab — in Russia, this polypeptide complex is put into action as a therapy to strengthen the immune system in day-to-day clinical settings.
Anti-aging is, of course, the area of Thymalin research that’s most attention-grabbing to researchers in the West. Studies have explored how Thymalin can fight immunosenescence — in plain English, age-related decline — of the thymus in both animal models and humans. The results? Both remarkable and worth studying further.
Animal studies consistently show longer lifespans and reduced risk of tumor formation (cancer is, unfortunately, among other things, a disease of old age). Human trials demonstrate similar potential, especially in relation to heart and lung disease. [3] Thymalin isn’t an “anti-aging peptide” in the sense that it targets the most visible signs of aging. Instead, the current body of research shows that it works on a deeper level. As it keeps the immune system young, it helps the body fight the more serious threats that come with age.
Chronic stress is bad enough on its own, but it also speeds up aging via HPA axis dysfunction. Thymalin has promise for the potential to act as a chemical reset. It reduces cortisol significantly in stressed models, while protecting neurons from oxidative damage. Research shows Thymalin precursors acting as stress signals. That is, Thymalin doesn’t only respond to stress, but anticipates stress, too, lowering inflammation before cascades begin. [4]
Thymalin protects cells from damage, but it also, research has demonstrated, repairs them. It activates p53 to help fix DNA damage caused by radiation or oxidative stress, while at the same time triggering mitochondrial repair. [5, 6]
In combination, these effects have implications for wound healing and trauma recovery — but also for healthier natural aging.
Thymalin isn’t a cancer treatment on its own, but it does have exciting potential as an adjunct therapy. Cutting-edge research (in this case, it’s more than a buzzword) shows that Thymalin can help patients’ immune systems recognize cancer cells, both earlier and more effectively. It does this by boosting T-killer and NK cell activity. [7]
The most promising aspect? Thymalin is in no way incompatible with chemotherapy or radiation treatment. In fact, Russian studies demonstrate that Thymalin can reduce infection rates in people who are being treated for cancer.
Thymalin has been studied for decades — with new findings still regularly emerging. It is no less interesting now than it was when it was first synthesized, and it’s most likely to catch the attention of people studying:
Some researchers are beginning to investigate Thymalin for its potential impact on autoimmune conditions, as well. Whatever your chosen area of study is, CellPeptides provides research-grade Thymalin to make your breakthroughs possible.
Decades of research give future investigators access to well-established dosing protocols. People investigating Thymalin typically begin with ranges from 0.1 to 0.5 mg to observe initial immune response and establish tolerance. Once this initial phase is complete, research doses are 1 to 5 mg per dose. More specifically, 1 to 2 mg for studies on aging and longevity, and 3 to 5 mg for acute immune challenges. These ranges are in line with Professor Khavinson’s studies.
Daily dosing is used for short-term immune boosts, while lifespan extension studies dose two or three times a week for more sustained periods of time.
To reconstitute Thymalin:
Thymalin keeps in the fridge at temperatures between 2 and 8°C for a maximum period of 60 days — discard if it’s cloudy. Don’t freeze reconstituted Thymalin.
What is Thymalin used for in research?
Thymalin — synthetic Thymulin — is most commonly studied for its potential effects on restoration of thymic function. It is used as an adjunct therapy in cancer patients, and researched for longevity, where it has been highly successful in animal models. Other areas of research include cell repair, stress regulation, and (increasingly) the management of autoimmune diseases.
Does Thymulin decline with age?
Dramatically so. It reaches its high point during childhood and sharply drops in middle age. As the thymus shrinks, Thymulin production goes down by 80 percent as early as age 40. This drop is associated with chronic inflammation and weakened immune function. Thymalin works to restore this function.
What are the potential side effects of Thymalin?
Serious side effects are rare, and redness at the injection site is the most common issue researchers run into.
Is Thymalin an antiviral?
Indirectly. Thymalin boosts the production of T-cells. T-cells help the body fight viruses and other pathogens from within. Doctors in Russia commonly prescribe Thymalin for this reason.
DISCLAIMER:
Our peptides can be used solely for in vitro experiments and cannot be:
Amino Acid Sequence | Pyr-Ala-Lys-Ser-Gln-Gly-Gly-Ser-Asn |
---|---|
Molecular Weight: | 858.86 g/mol |
Molecular Formula: | C₃₃H₅₄N₁₂O₁₅ |
CAS Number: | 63958-90-7 |
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