Purpose and Effects of Tesamorelin Peptide

*while CellPeptides provides pure and pharma-grade peptides – they are only approved for non-human research use only. The below effects and info are research-based information.

Release of growth hormones

Tesamorelin acts primarily to trigger growth hormone (GH) releases from the pituitary gland. The peptide aims to promote developments in body composition and improve metabolism while boosting overall health. GH helps boost muscle growth and reduce stored fat while enhancing the body’s potential to recover from injury.

The peptide also promotes an increase in insulin growth factor which has a positive effect on retaining and repairing muscle mass.

Reduction of visceral fat

Tesamorelin promotes the reduction of fat around main organs, particularly in persons dealing with lipodystrophy. The peptide acts against fat stored within the abdomen that usually surround the liver, intestines, and stomach. Too much visceral fat could pose a health risk and may lead to inflammation and cardiovascular disease.

Studies show that Tesamorelin acts to reduce harmful fat while helping patients lower the risk of health issues such deposits may cause.

Potential off-label use(s)

Tesamorelin gained its FDA approval for use as a GH stimulant; however, the peptide has gained popularity for several off-label uses. Some of its common uses besides its specified functions include:

Anti–aging

GH plays a vital role in maintaining youth and adequate metabolism. Some anti-aging enthusiasts include Tesamorelin in their regimen for its potential benefits.

Fat reduction

Persons looking to get rid of stubborn fat may look to Tesamorelin as a viable option. Some of these fitness enthusiasts rely on the peptide to eliminate stubborn fat around the abdomen. Research to determine the efficacy of Tesamorelin on fat reduction in the general population is ongoing.

Muscle gain

Tesamorelin boosting muscle maintenance and growth by boosting GH and IGF-1 levels makes it an attractive option for bodybuilders and athletes.

Tesamorelin’s Quantity and Forms

Quantity

The peptide comes as a lyophilized powder which weight is 5mg. Vials are available under controlled distribution to ensure the safety and efficacy of Tesamorelin during use.

Forms

Tesamorelin is usually available as an injectable solution. These injections go below the skin and into the bloodstream to promote fast action. Direct injections of Tesamorelin interact with the pituitary gland within minutes to boost stimulation and GH release.

Usage Instructions

• typically administered once daily,
• recommended dose for HIV-associated lipodystrophy is usually between 1 and 2 mg per 24hrs,
• follow the prescribed dosage and do not exceed the recommended amount without consulting a healthcare provider,
• thighs, abdomen, and the upper arm are common injection sites for Tesamorelin
• higher doses do not necessarily result in better outcomes and may increase the risk of side effects

How do You Store Tesamorelin?

• store in a refrigerator at temperatures between 36°F and 46°F (2-8 degrees celsius).
• it should be used within a few days after reconstitution (once mixed with sterile water),
• do not freeze the peptide to ensure its molecular structure and effectiveness are intact

Ingredient(s)

Pharmaceutical-grade Tesamorelin; approved for non-human research purposes.

Purity Level of CellPeptides’ Tesamorelin

The purity of Tesamorelin can determine its level of effectiveness. Pharmaceutical-grade Tesamorelin usually comes with over 98% purity to ensure safe administration and efficacy.

How Does Tesamorelin Work?

Mode of action

Tesamorelin mimics the natural GHRH in the hypothalamus. It binds to receptors in the pituitary gland and enhances the release of GH. The process boosts GH circulating levels and triggers the production of IGF-1. This action plays vital roles in maintaining muscle, fat metabolism, and tissue repair.

Impact on IGF-1

Tesamorelin working to elevate IGF-1 boosts the reduction of abdominal fat while supporting the preservation of muscle. This makes it a vital peptide for persons keen to enhance their body composition.

Impact of consistent use on GH levels and fat reduction

Studies show that Tesamorelin can boost the reduction of fat around organs, particularly in users dealing with lipodystrophy. Long-term increase of GH through Tesamorelin leads to an improved ability to burn fat. Some studies also suggest the peptide can support better energy levels and improved well-being.

Who Is Tesamorelin For?

Aging population

Older people tend to experience declining GH levels as they age, and this usually causes reduced muscle mass and fat gain. Tesamorelin acts to support older people manage their declining GH levels for increased body composition and overall health.

Bodybuilders and athletes

Fitness enthusiasts, bodybuilders, and athletes may rely on this peptide as an off-label option to manage fat distribution while retaining muscle mass.

HIV patients with lipodystrophy

Tesamorelin aims to support HIV patients experiencing symptoms of lipodystrophy. The medication provides active support to ensure removal of visceral fat. It also supports better fat distribution and improves resistance against symptoms linked with lipodystrophy.

Expected Effects

Tesamorelin encourages slight reduction of fat levels, particularly around the abdominal region. Its initial effects will trigger a reduction in waist circumference if coupled with other potent and compatible methods. These effects could be mild initially but become more visible with consistent use.

Continuous use of this medication will trigger more fat reduction and improved body composition over the long-term. Changes in mood and vitality levels will also be easier to notice after measured and consistent use of this peptide.

When Will the Results of Tesamorelin Become Obvious?

Short-term effects

Users may notice changes in body composition with a month after starting the Tesamorelin medication. Common effects of this medication can trigger reduced bloating, better energy levels, and slight reduction of fat.

Long-term effects

Tesamorelin promotes fat reduction over the long-term with results becoming evident after few months of use. Long-term gains from using this peptide start showing after 6 months of use and may include better retention of muscle and improved body metabolism. Continuous dosing cycles may help maintain these results; however, medical supervision is necessary to achieve proper use of this peptide without side effects.

Ways to maintain results

Users who wish to maintain fat loss will find Tesamorelin useful. Ongoing use will help maintain this results and stop gradual slides to baseline fat levels.

Tesamorelin Dosage Guidelines

Recommended doses of Tesamorelin range between 0.5-1mg and 2mg per 24hrs and largely depends on medical advice and individual needs. Persons dealing with lipodystrophy may need stable 2mg doses while off-label users may use this medication based on their response after administration.
It should be taken before bedtime to mimic natural GH secretion.

Safety and Potential Side Effects

Most users of Tesamorelin tolerate the medication well; however, some side effects may occur that include:

• Redness or swelling at the injection area,
• Nausea,
• Headaches,
• Muscle or joint pain

These side effects are usually minimal and subside when the body begins to adjust to Tesamorelin shots. Serious side effects like insulin resistance, changes in blood sugar level, or Carpal Tunnel syndrome may arise from Tesamorelin abuse. Seek guidance from a qualified healthcare professional before adopting this peptide to any needs you have planned.

FAQs About Tesamorelin

Can I use Tesamorelin for the long-term?

Tesamorelin can be a long-term medication, especially for persons who seek its functions to maintain muscle and reduce abdominal fat around organs. However, off-label uses for weight loss programs or far reduction does not have detailed research backing. It is essential to use the peptide after securing professional advice and guidance from a qualified healthcare practitioner.

Can I use Tesamorelin for weight loss?

Tesamorelin does not have any classification as a weight loss drug, even if it helps reduce abdominal fat. The peptide received its FDA approval for use in treating lipodystrophy; however, some off-label users add this medication to their weight loss regimen.

Does Tesamorelin help build muscle?

The main function of Tesamorelin is to retain muscle mass and not to build new tissue. It aims to maintain muscle and repair damaged tissue by its stimulation of GH and IGF-1 levels, especially during fat loss.

How long does Tesamorelin stay in your system?

Tesamorelin has a short half-life and may leave the system in less than an hour. However, its effect to increase GH and IGF-1 levels can last for hours. Users who require the benefits of this peptide may have to take it daily during their dosing cycle.

Is Tesamorelin legal?

Tesamorelin is legal and is an FDA-approved medication for the treatment of lipodystrophy, a condition common in HIV patients. The drug gains popularity for its off-label uses in anti-aging and weight loss, even if it has no clear approval for such purposes.

References

Benedini S, Terruzzi I, Lazzarin A, Luzi L (2008). Recombinant Human Growth Hormone: Rationale for Use in the Treatment of HIV-Associated Lipodystrophy. BioDrugs. 22 (2): 101–112. doi:10.2165/00063030-200822020-00003.

Dhillon S (2011). Tesamorelin: A Review of Its Use in the Management of HIV-Associated Lipodystrophy. Drugs. 71 (8): 1071–1091. doi:10.2165/11202240-000000000-00000. PMID 21668043.

Falutz J, Potvin D, Mamputu JC, Assaad H, Zoltowska M, Michaud SE, et al. (2010). Effects of Tesamorelin, a Growth Hormone-Releasing Factor, in HIV-Infected Patients with Abdominal Fat Accumulation: A Randomized Placebo-Controlled Trial with a Safety Extension. Journal of Acquired Immune Deficiency Syndromes. 53 (3): 311–322. doi:10.1097/qai.0b013e3181cbdaff. PMID 20101189.

Ferdinandi ES, Brazeau P, High K, Procter B, Fennell S, Dubreuil P (2007). Non-Clinical Pharmacology and Safety Evaluation of TH9507, a Human Growth Hormone-Releasing Factor Analogue. Basic & Clinical Pharmacology & Toxicology. 100 (1): 49–58. doi:10.1111/j.1742-7843.2007.00008.x. PMID 17214611.

Patel A, Gandhi H, Upaganlawar A (2011). Tesamorelin: A Hope for ART-Induced Lipodystrophy. Journal of Pharmacy & Bioallied Sciences. 3 (2): 319–320. doi:10.4103/0975-7406.80763. PMC 3103937.