MOTS-c 10mg

Why Choose CellPeptides’ MOTS-C?

“Trust us” isn’t a research strategy. Transparency is. CellPeptides provides lab-grade MOTS-c for scientists chasing the next breakthrough in metabolic health. Our peptides are made in a WHO/GMP and ISO 9001:2015 certified lab in the EU. They’re also:

• Manufactured to ≥99% purity — lab-grade and ready for research.
• Third-party tested, with certificates of analysis you can read yourself to check purity and composition.
• Shipped securely, in discreet packaging — with tracking and insurance.

Pay by credit card or bank transfer if you like, but CellPeptides also accepts cryptocurrency. And if you have any questions? We have a customer service team to answer them, whether they’re about MOTS-c or your order.

How Does MOTS-c Work?

MOTS-c is a homeostatic regulator — it works hard to restore the body to its natural, optimal balance, especially when that balance is lost because of a bad diet, too much exercise, or sleep deprivation. It does that in three different ways.

MOTS-c activates AMPK, an enzymatic “cellular energy booster,” to get more glucose into the muscles, improve fatty acid oxidation (AKA help burn fat), and pause processes that take energy (like storing fat!). It induces the same metabolic effects seen during exercise — but without necessarily needing to exercise. It also increases AMPK in a different way, unique to this peptide. MOTS-c regulates the folate cycle.

MOTS-c can do something most peptides don’t. It can go directly into the nucleus of cells. Once there, MOTS-c tweaks gene expression — specifically, the genes needed to defend against antioxidants and create better metabolic balance.

That’s how MOTS-c does what it does, but what does that all that mean for research? That part is exciting, too, so let’s go there next.

MOTS-c in Research: Muscle Performance, Fat Burning, and Longevity

MOTS-c research is undeniably still in its early phase — inevitable when you consider that the peptide was only discovered recently in the grand scheme of things. Despite that, researchers are obsessed (did we mention MOTS-c was basically responsible for creating a whole new field of biology?). The studies are coming in fast. Yes, they’re all fascinating.

Current research may just be scratching the surface, but the most well-studied areas are related to longevity, metabolism, and cell health (with findings that might surprise you).

MOTS-c and the Potential for Healthier, More Energetic Aging

Natural MOTS-c levels are at their highest during youth. As with so many peptides, it’s all downhill from there — and that itself may have a lot to do with the visible and less visible signs of aging that research is always trying to slow down and even reverse.

So far, research demonstrates that MOTS-c has the potential to restore lost balance, with positive effects on age-related diseases that include diabetes, osteoporosis, menopause-related weight gain, and muscle loss. [1] More than that, MOTS-c keeps energy levels up (down to the cellular level!). It’s been investigated for its ability to improve muscle mass and strength in aging populations, too [2] — research that continues, so pay attention to new findings.

MOTS-c in Endurance and Exercise Studies

Does the same mechanism that improves muscle mass and strength in elderly subjects also benefit younger ones? In other words, does MOTS-c have a use case as a peptide for athletic performance and endurance? Animal studies show that the answer is “yes,” because MOTS-c improved fitness in mice of all ages. [3]

It appears to reduce muscle loss by improving glucose uptake [4] — and while exercising naturally boosts MOTS-c, supplementation has the same effect without movement. Researchers in sports medicine should listen up, but MOTS-c is even more valuable for people who cannot exercise, for example because they’re recovering from surgery or have physical disabilities.

Obesity and Fat Metabolism Research

Since the discovery of 2015, researchers have found that obese children have lower than average MOTS-c levels — and that this fact might contribute to the high rates of obesity-related diseases. [5] Studies have continued from there, and time and time again, they come to the same conclusion. Because MOTS-c promotes homeostasis (that is, essentially, healthy and balanced functioning), it can also improve insulin sensitivity and fight obesity. Interestingly, research has shown models to have good insulin sensitivity even on high-fat diets. [6]

MOTS-c for Bone Health and Osteoporosis

New research hints at unexpected and surprisingly positive use cases for MOTS-c. Of these, its potential to prevent osteoporosis by recruiting osteoblasts, cells that make new bone cells, is among the most exciting. MOTS-c successfully stopped bone loss in high-risk subjects in the studies carried out to date. [7, 8] When you keep in mind that menopause — which, of course, catches up with all women at some point in their lives — is one of the biggest risk factors for osteoporosis, it’s immediately clear that these findings might change female aging forever.

What’s Next for MOTS-c Research?

In the short time since it’s been discovered, MOTS-c has made waves. With implications for managing metabolic disease, non-alcoholic fatty liver disease, athletic performance, bone health, illness recovery, heart health, and more. The mitochondrial genome was understudied for a long time. Not anymore. New applications for MOTS-c are still being researched, but the core potential — that boosting MOTS-c means better health across the board, for longer — is itself fertile ground for endless study.

Who Might Consider MOTS-c?

A peptide that nobody knew existed until 2015, but that sends messages from the mitochondria to the rest of the cell and further beyond — to restore energy, bring the metabolism back into balance, and regulate stress — should grab the attention of anyone interested in peptide research.

General wellness applications include healthy weight maintenance and athletic performance, but they also include bone loss prevention, younger cells, and more energy. More specific areas of study look at reversing insulin resistance, protecting cognitive and heart health in the face of oxidative stress.

MOTS-c has been promising in:

• Athletic performance and recovery research — including following injury.
• Obesity management and diabetes studies.
• Longevity+ — that is, research among biohackers who aren’t satisfied with a longer life, and who want a healthier, more active, more energetic life that also happens to be long.

Research directions are endless. What’s yours?

Common Researched Dosing Protocols for MOTS-c In Studied In-vitro Setting

CelllPeptides provides pharmaceutical-grade peptides for research, but it’s up to investigators to design appropriate protocols for their study. The existing body of research has led to examples of dosing protocols. Most studies start with doses of between 0.1 and 0.5 mg, which allows researchers to observe how the model responds. Past that initial phase, doses of 1 to 3 mg are common — daily for short-term research projects and three to four times per week for long-term studies.

Reconstitution is completed by adding 1 mL of bacteriostatic water (available from CellPeptides, too) to a 10 mg vial of MOTS-c. As always, swirl to dissolve and be careful not to shake it. After it’s reconstituted, keep MOTS-c stored between 2 and 8°C and use the peptide in the next 30-60 days.

Follow lab protocols to the letter. You know the drill — alcohol wipes, gloves, sterile syringes, lab coats, and logs.

If you need visual guidance on how much peptide to draw once it’s reconstituted — you can use our comprehensive peptide calculator here.

FAQ

What does the MOTS-c peptide do?

MOTS-c helps to restore balance to the cells. Research is still very much in full swing, but studies so far show better insulin sensitivity and endurance, along with more efficient fat loss.

Does MOTS-c help with weight loss?

Early research has positive results — and it demonstrates proof of concept. MOTS-c stops the body from hoarding fat and switches on fat loss mode, but in animal models. Human trials are coming next.

Can MOTS-c build muscle?

Not directly, but MOTS-c does help prevent muscle atrophy and improve endurance.

Is MOTS-c a peptide?

Yep, MOTS-c is a peptide — it’s a chain of 16 amino acids. It’s radically different from other peptides, though, and behaves more like a hormone because it goes into the cell nucleus to tweak genetic expression.

What are the side effects of MOTS-c?

Very few documented. Some redness is always possible, and very high doses might cause flushing.

DISCLAIMER:

Our peptides can be used solely for in vitro experiments and cannot be:

• Used in clinical trials involving humans
• Administered to humans as part of an experiment or investigation
• Supplied to another party for human investigational use

Scientific References

1. https://www.mdpi.com/1422-0067/23/19/11991
2. https://link.springer.com/article/10.1186/s12967-023-03885-2
3. https://www.nature.com/articles/s41467-020-20790-0
4. https://www.cell.com/iscience/fulltext/S2589-0042(24)02437-4?uuid=uuid%3A215131af-016f-496e-aa23-7c1986beac61
5. https://www.tandfonline.com/doi/full/10.2147/DMSO.S403934
6. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(15)00061-3
7. https://www.europeanreview.org/wp/wp-content/uploads/7156-7163.pdf
8. https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2023.1149120/full