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The harder the challenge, the trickier it is to find the right peptide. Zapping over 20 percent of total body weight? Lowering HbA1c to less than prediabetic levels? Clinical trials show that Tirzepatide has the potential to make it happen. This next-gen diabetes management and weight loss compound uses dual action to get there. It mimics two natural incretins — GLP-1 and GIP — to stimulate insulin, keep glucagon down, slow digestion, slash appetite, and potentially help the body store less fat. Beyond that, research into the cardiovascular benefits of Tirzepatide is also in full swing. So far, studies have shown lowered blood pressure and better cholesterol levels.
Exciting? Researchers are kind of obsessed. For people investigating weight loss science, metabolic health, cardiovascular health, and longevity (both the heart and brain have GIP receptors). The science is stacking up. Where will you take it?
Researchers trust CellPeptides for their Tirzepatide studies because breakthrough science demands quality. We’re an EU-based (but deliver to USA as well without any issues) research company that never leaves you guessing. Our Tirzepatide is:
Pay by credit card, wire transfer, or with cryptocurrency — CellPeptides means it when we say “flexible payment options.” And if you get stuck? Our customer service will help you make sure it doesn’t last long.
Tirzepatide, developed as a next-gen diabetes treatment before being studied in other areas, works in two ways — because it’s modeled after two key hormones.
Glucagon-Like Peptide-1 is the first. It instructs the pancreas to start releasing insulin when blood sugar levels are high, and not when they’re not — something that cuts the risk of hypoglycemia. GLP-1 also suppresses glucagon to lower overall blood sugar levels. The hormone keeps people feeling full for longer by slowing gastric emptying, and it tells the appetite centers in the brain they don’t need to pump out hunger signals.
Glucose-Dependent Insulinotropic Polypeptide is the second hormone that Tirzepatide mimics. That one is thought to tell the pancreas to release insulin and boost energy metabolism (convert nutrients to energy, rather than store them as fat).
Activate both at the same time, as Tirzepatide does, and the two work together to produce more profound effects than they’d have alone.
Research has demonstrated the following benefits in clinical trial participants given Tirzepatide:
The compound is FDA-approved for obesity and type 2 diabetes, but its successes to date don’t put a stop to future research opportunities. Other interesting potential applications are still being studied.
The promise Tirzepatide has shown in treating obesity and type 2 diabetes [1] dominates the headlines — no surprise when you think about its dramatic results. Early data also hints at far broader use cases, however. Worth reading more about? This taste is sure to get researchers interested.
That’s the attention grabber. You’ve already seen the results. Terzapatide was shown, in a large but still growing number of studies, to be highly effective at inducing weight loss in obese patients. [2] The combination of slowing digestion (and making feelings of satiety last) and reducing appetite makes this possible. Dramatic results wherein people lose 20, 22, or even 25 percent of their starting body weight are not uncommon.
Maintenance often proves difficult after achieving the target weight, regardless of the weight loss method. That makes it all the more promising that the vast majority of patients participating in clinical trials with Tirzepatide were able to maintain at least 88 percent of their loss, for at least 12 months. [3] Just as importantly, Tirzepatide tackles liver fat and abdominal fat — the most dangerous kind. [4]
In research, a significant portion of type 2 diabetics achieved their HbA1c goals across all three Tirzepatide dosing structures — 5, 10, and 15 mg. Tirzepatide was more effective than long-acting insulin. [5] (Read that again. Let it sink in.) What’s more, while the risk of hypoglycemia is (as is to be expected) among the most common adverse effects associated with Tirzepatide, it’s relatively low. Lower than with insulin. [6]
People researching Tirzepatide should also be interested in its potential to improve cardiovascular health. This area is not quite as well studied yet as type 2 diabetes and weight loss applications, but already backed by solid evidence. Tirzepatide has been associated with significantly reduced blood pressure, lower total cholesterol, lower LDL and triglyceride levels, and improved HDL. [7]
Overweight is the biggest risk factor for sleep apnea, but it also occurs in people who aren’t obese. So far, trials studying obese patients have found that Tirzepatide reduces sleep apnea episodes and related health markers — and improved sleep quality. [8]
Activating GIP receptors doesn’t only affect insulin and metabolic health. Early animal studies show that it may also boost cognition and cognitive health. [9] This area of study is still very much emerging, but the potential for research is clear. Tirzepatide mimics the effect of GIP. Tirzepatide as a potential cognitive booster is an area of science waiting to be explored.
Tirzepatide is the first dual-action GLP-1 + GIP peptide with serious clinical results. Who’s researching it? You can guess.
There’s rich research potential — including to investigate the interaction of Tirzepatide with other peptides.
Thanks to the SURMOUNT/SURPASS trials, dosing protocols for Tirzepatide are well established. Standard dosing on trial research was made was once a week, generally in the morning, and gradually increases to get the body used to the compound and minimize side effects:
(Researchers often split the dose into 2x per week to minimize side-effects)
Most protocols include 12 to 16 weeks of weekly doses followed by a four-week break. That break is meant to prevent receptor desensitization and keep Tirzepatide working.
Reconstituting Tirzepatide is done by adding 1-2 mL bacteriostatic water (add it to your basket; we have it) to a 5 mg vial. Swirl — gently does it — until it’s clear. Keep Tirzepatide in the fridge. It can be stored for up to 60 days.
Tirzepatide causes some trial participants to experience nausea and mild diarrhea. It interacts with some medications and isn’t appropriate for everyone. Trial participants should be carefully selected.
What to eat while on Tirzepatide?
Researchers prefer to prioritize protein and fiber rich foods while investigating Tirzepatide. Greasy and fatty foods are best avoided. This minimizes side effects while maximizing results. Hydration is important, too — to help the digestive system perform as gastric emptying starts to reduce appetite.
What happens when you stop taking Tirzepatide?
Most current obesity trials show that significant portions of participants managed to keep most of the weight they lost off for a year. Maintenance dosing can help if losses start to turn into gains. As for type 2 diabetes, stopping Tirzepatide leads to a gradual increase to the HbA1c levels seen before starting the compound.
Who is not a good candidate for Tirzepatide?
Tirzepatide is not suitable for people with a history of pancreatitis, MEN-2 syndrome, kidney and gallbladder disease, and several other conditions. A thorough checkup that includes discussion about suitability is always necessary.
What to expect when you first start Tirzepatide?
Tirzepatide does not work instantly. In studies, it was most common for appetite suppression to kick in during the second week of the trial. Weight loss and blood sugar control follow. Some people have slight nausea during the first week. Starting Tirzepatide with a low dose of 2.5 mg helps the body adjust.
Is Tirzepatide better than Semaglutide?
Both Semaglutide and Terzaptide have been found to be effective for weight loss/obesity treatment and blood sugar control in diabetes in a growing number of studies, with more still coming out. Tirzepatide has significantly stronger effects. Those are not always necessary. Tirzepatide is also more expensive. Tirzepatide is, however, often more effective for treatment-resistant obesity.
DISCLAIMER:
Our peptides can be used solely for in vitro experiments and cannot be:
Amino Acid Sequence: | H-Tyr-{Aib}-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Ile-{Aib}-Leu-Asp-Lys-Ile-Ala-Gln-{diacid-γ-Glu-(AEEA)₂-Lys}-Ala-Phe-Val-Gln-Trp-Leu-Ile-Ala-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH₂ |
---|---|
Molecular Weight: | 4,813.45 g/mol |
Molecular Formula: | C₂₂₅H₃₄₈N₄₈O₆₈ |
CAS Number: | 2023788-19-2 |
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