Animal studies have examined SLU-PP-332 as an experimental exercise-mimetic compound. In mice, ERR activation increased oxidative type IIa muscle fibers and improved exercise endurance. Separate obesity and metabolic-syndrome studies reported increased energy expenditure and fatty-acid oxidation, together with reduced fat accumulation and improved insulin sensitivity.

SLU-PP-332 has also been investigated beyond skeletal muscle. In aged mice, ERR activation was associated with improved mitochondrial function and reductions in inflammatory signaling within the kidney, while experimental heart-failure models found improvements in cardiac mitochondrial metabolism and cardiac function. These findings remain préclinique, and controlled human evidence establishing efficacy or safety is currently lacking.