{"id":7605,"date":"2025-12-03T15:21:59","date_gmt":"2025-12-03T15:21:59","guid":{"rendered":"https:\/\/cellpeptides.com\/?post_type=product&#038;p=7605"},"modified":"2026-06-09T03:12:55","modified_gmt":"2026-06-09T10:12:55","slug":"5-amino-1mq-5mg","status":"publish","type":"product","link":"https:\/\/cellpeptides.com\/sl\/product\/5-amino-1mq-5mg\/","title":{"rendered":"5-Amino-1MQ 5mg"},"content":{"rendered":"<h2>What Is 5-Amino-1MQ &amp; Its Mechanism of Action?<\/h2>\n<p><strong data-start=\"0\" data-end=\"15\" data-is-only-node=\"\">5-Amino-1MQ<\/strong> (5-amino-1-methylquinolinium) is a small-molecule, cell-permeable <strong data-start=\"82\" data-end=\"138\">inhibitor of nicotinamide N-methyltransferase (NNMT) <\/strong>\u2014 the enzyme that methylates nicotinamide (NAM) to 1-methylnicotinamide (1-MNA) using S-adenosyl-methionine (SAM) as the methyl donor. By <strong data-start=\"275\" data-end=\"292\">blocking NNMT<\/strong>, 5-Amino-1MQ:<\/p>\n<ul>\n<li><strong data-start=\"310\" data-end=\"375\">prevents diversion of NAM away from the NAMPT salvage pathway<\/strong>, which can increase intracellular <strong data-start=\"410\" data-end=\"418\">NAD\u207a<\/strong> availability, and<\/li>\n<li><strong data-start=\"442\" data-end=\"486\">conserves the cellular methyl-donor pool<\/strong> (shifting the <strong data-start=\"501\" data-end=\"512\">SAM\/SAH<\/strong> balance), with downstream effects on epigenetic methylation and gene expression.<\/li>\n<\/ul>\n<p>At the enzyme level it binds within NNMT\u2019s <strong data-start=\"637\" data-end=\"657\">substrate pocket<\/strong> with high selectivity; at the cellular level this reprograms metabolic signaling (e.g., sirtuin-dependent pathways) and has been shown in vitro and in rodent studies to <strong data-start=\"827\" data-end=\"842\">lower 1-MNA<\/strong>, <strong data-start=\"844\" data-end=\"881\">reduce adipocyte lipogenesis\/size<\/strong>, and <strong data-start=\"887\" data-end=\"918\">increase energy expenditure<\/strong>. In short, 5-Amino-1MQ acts as a metabolic\/epigenetic \u201cnode\u201d by inhibiting NNMT, thereby impacting <strong data-start=\"1018\" data-end=\"1031\">NAD\u207a flux<\/strong> and <strong data-start=\"1036\" data-end=\"1061\">methylation potential<\/strong> rather than directly activating a receptor.<\/p>\n<p>&nbsp;<\/p>\n<h2>5-Amino-1MQ Effects on the Body &amp; Why It Matters?<\/h2>\n<p data-start=\"0\" data-end=\"499\">It blocks <strong data-start=\"74\" data-end=\"82\">NNMT<\/strong>, an enzyme that wastes niacin (NAM) and methyl groups, so your cells keep more <strong data-start=\"162\" data-end=\"170\">NAD\u207a<\/strong> for mitochondrial upkeep and more <strong data-start=\"205\" data-end=\"212\">SAM<\/strong> for healthy methylation. That upstream tweak can ripple through energy, fat storage, and cellular stress \u2014 less biochemical \u201cdrag,\u201d more efficient housekeeping. Most evidence so far is <strong data-start=\"396\" data-end=\"411\" data-is-only-node=\"\">preclinical<\/strong> (cells\/animals), but the story is consistent: free up resources &#8211; systems run smoother.<\/p>\n<p data-start=\"501\" data-end=\"536\"><strong data-start=\"501\" data-end=\"536\">What it may do:<\/strong><\/p>\n<ul data-start=\"537\" data-end=\"1315\">\n<li data-start=\"537\" data-end=\"688\">\n<p data-start=\"539\" data-end=\"688\"><strong data-start=\"539\" data-end=\"560\">Raise usable NAD\u207a<\/strong> \u2013 by stopping NAM from being siphoned off, it feeds the NAD\u207a salvage loop, supporting mitochondrial enzymes (e.g., sirtuins).<\/p>\n<\/li>\n<li data-start=\"689\" data-end=\"827\">\n<p data-start=\"691\" data-end=\"827\"><strong data-start=\"691\" data-end=\"723\">Preserve methyl donors (SAM)<\/strong> \u2013 less NNMT activity means a better SAM:SAH balance, which can steady <strong data-start=\"794\" data-end=\"808\">epigenetic<\/strong> gene regulation.<\/p>\n<\/li>\n<li data-start=\"828\" data-end=\"960\">\n<p data-start=\"830\" data-end=\"960\"><strong data-start=\"830\" data-end=\"854\">Shrink fat-cell size<\/strong> \u2013 adipocytes tend to store less and burn more, trimming hypertrophy (seen in rodent\/adipocyte studies).<\/p>\n<\/li>\n<li data-start=\"961\" data-end=\"1089\">\n<p data-start=\"963\" data-end=\"1089\"><strong data-start=\"963\" data-end=\"997\">Nudge metabolism toward \u201cburn\u201d<\/strong> \u2013 downstream of higher NAD\u207a\/sirtuins, cells often show higher energy expenditure signals.<\/p>\n<\/li>\n<li data-start=\"1090\" data-end=\"1205\">\n<p data-start=\"1092\" data-end=\"1205\"><strong data-start=\"1092\" data-end=\"1118\">Tame inflammatory tone<\/strong> \u2013 improved redox control and signaling can dial back some pro-inflammatory pathways.<\/p>\n<\/li>\n<li data-start=\"1206\" data-end=\"1315\">\n<p data-start=\"1208\" data-end=\"1315\"><strong data-start=\"1208\" data-end=\"1230\">Lower 1-MNA levels<\/strong> \u2013 a direct readout of NNMT inhibition; useful as a biochemical \u201cproof it\u2019s working.\u201d<\/p>\n<\/li>\n<\/ul>\n<p data-start=\"1317\" data-end=\"1401\"><em data-start=\"1317\" data-end=\"1324\">Note:<\/em> These effects come from early research, not medical claims or dosing advice.<\/p>\n<p>&nbsp;<\/p>\n<h2>5-Amino-1MQ Dosing protocol In-Vitro Research Fields<\/h2>\n<ul data-start=\"256\" data-end=\"731\">\n<li data-start=\"256\" data-end=\"399\">\n<p data-start=\"258\" data-end=\"399\"><strong data-start=\"258\" data-end=\"276\">Oral capsules:<\/strong> <strong data-start=\"277\" data-end=\"294\">50\u2013100 mg\/day<\/strong> (often split <strong data-start=\"308\" data-end=\"324\">25\u201350 mg BID<\/strong>); some quote <strong data-start=\"338\" data-end=\"355\" data-is-only-node=\"\">50\u2013150 mg\/day<\/strong> and \u201ccycles\u201d of ~8\u201312 weeks with breaks.<\/p>\n<\/li>\n<li data-start=\"400\" data-end=\"612\">\n<p data-start=\"402\" data-end=\"612\"><strong data-start=\"402\" data-end=\"441\">\u201cInjectable\u201d protocols sold online:<\/strong> <strong data-start=\"442\" data-end=\"460\">150\u2013600 \u00b5g\/day<\/strong> with step-up schedules over 4\u201312 weeks (note the <strong data-start=\"510\" data-end=\"523\">microgram<\/strong> units\u2014this conflicts with capsule <strong data-start=\"558\" data-end=\"564\" data-is-only-node=\"\">mg<\/strong> regimens and reflects nonstandard products).<\/p>\n<\/li>\n<\/ul>\n<p>Use our <a href=\"https:\/\/cellpeptides.com\/peptide-dosage-calculator\/\">peptide dosage calculator<\/a> in order to find out the correct dose for your model.<\/p>\n<h2><b>Why Choose CellPeptides for Your 5-Amino-1MQ Research?<\/b><\/h2>\n<p><span style=\"font-weight: 400;\">CellPeptides is an EU-based research chemical company who tries to live up to that exciting legacy. We provide pharmacological-grade SLU-PP-332 with the potential to form the basis for brand new discoveries.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">With us, you get:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">\u226599% purity \u2014 as pure as it gets, and completely ready for your ambitious study design.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Certificates of analysis from independent labs, so you can check purity and composition for yourself.\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Fast, global, insured, and <\/span><i><span style=\"font-weight: 400;\">safe<\/span><\/i><span style=\"font-weight: 400;\"> shipping. With tracking, of course.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Flexibility when it comes to payment. Don\u2019t like credit cards or bank transfers? We take crypto, too.\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">A knowledgeable support team that will get your questions answered \u2014 if there\u2019s a glitch with your order, but also if you\u2019d like to run your research design by us.<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">We handle the reliability (our 5-Amino-1MQ is synthesized in an EU-based WHO\/GMP and ISO 9001:2015 certified lab), so you get the compound you need to contribute to the future of science. Every time.<\/span><\/p>\n<h2><em><b>Scientific References<\/b><\/em><\/h2>\n<ul>\n<li data-start=\"50\" data-end=\"243\">\n<p data-start=\"52\" data-end=\"243\">Neelakantan H. et al. <strong data-start=\"74\" data-end=\"188\">Selective and membrane-permeable small-molecule NNMT inhibitors reverse high-fat diet\u2013induced obesity in mice.<\/strong><br data-start=\"188\" data-end=\"191\" \/><a class=\"decorated-link\" href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC5826726\/\" target=\"_blank\" rel=\"noopener\" data-start=\"193\" data-end=\"242\" data-is-only-node=\"\">https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC5826726\/<\/a><\/p>\n<\/li>\n<li data-start=\"245\" data-end=\"465\">\n<p data-start=\"247\" data-end=\"465\">Neelakantan H. et al. <strong data-start=\"269\" data-end=\"343\">Structure\u2013Activity Relationship for Small-Molecule Inhibitors of NNMT.<\/strong> <em data-start=\"344\" data-end=\"356\">J Med Chem<\/em> (SAR incl. 5-Amino-1MQ).<br data-start=\"381\" data-end=\"384\" \/><a class=\"decorated-link\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/28548833\/\" target=\"_blank\" rel=\"noopener\" data-start=\"386\" data-end=\"427\">https:\/\/pubmed.ncbi.nlm.nih.gov\/28548833\/<\/a> <span class=\"\" data-state=\"closed\"><span class=\"ms-1 inline-flex max-w-full items-center relative top-[-0.094rem] animate-[show_150ms_ease-in]\" data-testid=\"webpage-citation-pill\"><a class=\"flex h-4.5 overflow-hidden rounded-xl px-2 text-[9px] font-medium transition-colors duration-150 ease-in-out text-token-text-secondary! bg-[#F4F4F4]! dark:bg-[#303030]!\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/28548833\/\" target=\"_blank\" rel=\"noopener\"><span class=\"relative start-0 bottom-0 flex h-full w-full items-center\"><span class=\"flex h-4 w-full items-center justify-between overflow-hidden\"><span class=\"max-w-[15ch] grow truncate overflow-hidden text-center\">PubMed<\/span><\/span><\/span><\/a><\/span><\/span><\/p>\n<\/li>\n<li data-start=\"467\" data-end=\"648\">\n<p data-start=\"469\" data-end=\"648\">Sampson C.M. et al. <strong data-start=\"489\" data-end=\"541\">Combined NNMT inhibition and calorie restriction<\/strong> (microbiome &amp; metabolic effects; uses 5-Amino-1MQ).<br data-start=\"593\" data-end=\"596\" \/><a class=\"decorated-link\" href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7952898\/\" target=\"_blank\" rel=\"noopener\" data-start=\"598\" data-end=\"647\">https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7952898\/<\/a><\/p>\n<\/li>\n<li data-start=\"650\" data-end=\"850\">\n<p data-start=\"652\" data-end=\"850\">Dimet-Wiley A.L. et al. <strong data-start=\"676\" data-end=\"742\">NNMT inhibition mimics\/boosts exercise benefits in aged muscle<\/strong> (5-Amino-1MQ).<br data-start=\"757\" data-end=\"760\" \/><a class=\"decorated-link\" href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC11226645\/\" target=\"_blank\" rel=\"noopener\" data-start=\"762\" data-end=\"812\">https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC11226645\/<\/a> <span class=\"\" data-state=\"closed\"><span class=\"ms-1 inline-flex max-w-full items-center relative top-[-0.094rem] animate-[show_150ms_ease-in]\" data-testid=\"webpage-citation-pill\"><a class=\"flex h-4.5 overflow-hidden rounded-xl px-2 text-[9px] font-medium transition-colors duration-150 ease-in-out text-token-text-secondary! bg-[#F4F4F4]! dark:bg-[#303030]!\" href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC11226645\/\" target=\"_blank\" rel=\"noopener\"><span class=\"relative start-0 bottom-0 flex h-full w-full items-center\"><span class=\"flex h-4 w-full items-center justify-between overflow-hidden\"><span class=\"max-w-[15ch] grow truncate overflow-hidden text-center\">PMC<\/span><\/span><\/span><\/a><\/span><\/span><\/p>\n<\/li>\n<li data-start=\"852\" data-end=\"1062\">\n<p data-start=\"854\" data-end=\"1062\">Dimet-Wiley A.L. et al. <strong data-start=\"878\" data-end=\"932\">Reduced-calorie diet combined with NNMT inhibition<\/strong> (uses 5-Amino-1MQ).<br data-start=\"952\" data-end=\"955\" \/><a class=\"decorated-link\" href=\"https:\/\/www.nature.com\/articles\/s41598-021-03670-5\" target=\"_blank\" rel=\"noopener\" data-start=\"957\" data-end=\"1007\">https:\/\/www.nature.com\/articles\/s41598-021-03670-5<\/a> | PubMed: <a class=\"decorated-link\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35013352\/\" target=\"_blank\" rel=\"noopener\" data-start=\"1020\" data-end=\"1061\">https:\/\/pubmed.ncbi.nlm.nih.gov\/35013352\/<\/a><\/p>\n<\/li>\n<li data-start=\"1064\" data-end=\"1217\">\n<p data-start=\"1066\" data-end=\"1217\">Iyamu I.D. et al. <strong data-start=\"1084\" data-end=\"1121\">Mechanisms and inhibitors of NNMT<\/strong> (review; potency notes for 5-Amino-1MQ).<br data-start=\"1162\" data-end=\"1165\" \/><a class=\"decorated-link\" href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC8372200\/\" target=\"_blank\" rel=\"noopener\" data-start=\"1167\" data-end=\"1216\">https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC8372200\/<\/a><\/p>\n<\/li>\n<li data-start=\"1219\" data-end=\"1398\">\n<p data-start=\"1221\" data-end=\"1398\">Gao Y. et al. <strong data-start=\"1235\" data-end=\"1275\">NNMT: an emerging therapeutic target<\/strong> (review; SAR mentions 5-Amino-1MQ IC\u2085\u2080 \u2248 1.2 \u00b5M).<br data-start=\"1325\" data-end=\"1328\" \/><a class=\"decorated-link\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1359644621002427\" target=\"_blank\" rel=\"noopener\" data-start=\"1330\" data-end=\"1397\">https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1359644621002427<\/a><\/p>\n<\/li>\n<li data-start=\"1400\" data-end=\"1579\">\n<p data-start=\"1402\" data-end=\"1579\">Sun W.D. et al. <strong data-start=\"1418\" data-end=\"1457\">NNMT: a novel pharmaceutical target<\/strong> (Frontiers review, 2024).<br data-start=\"1483\" data-end=\"1486\" \/><a class=\"decorated-link\" href=\"https:\/\/www.frontiersin.org\/journals\/pharmacology\/articles\/10.3389\/fphar.2024.1410479\/full\" target=\"_blank\" rel=\"noopener\" data-start=\"1488\" data-end=\"1578\">https:\/\/www.frontiersin.org\/journals\/pharmacology\/articles\/10.3389\/fphar.2024.1410479\/full<\/a><\/p>\n<\/li>\n<li data-start=\"1581\" data-end=\"1729\">\n<p data-start=\"1583\" data-end=\"1729\">Li X.Y. et al. <strong data-start=\"1598\" data-end=\"1636\">NNMT as biomarker\/target in cancer<\/strong> (broad context; inhibitor landscape).<br data-start=\"1674\" data-end=\"1677\" \/><a class=\"decorated-link\" href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC9218565\/\" target=\"_blank\" rel=\"noopener\" data-start=\"1679\" data-end=\"1728\">https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC9218565\/<\/a><\/p>\n<\/li>\n<li data-start=\"1731\" data-end=\"1898\">\n<p data-start=\"1733\" data-end=\"1898\">Patent (methods &amp; data excerpts): <strong data-start=\"1767\" data-end=\"1819\">Quinoline-derived small-molecule NNMT inhibitors<\/strong> (incl. 5-Amino-1MQ).<br data-start=\"1840\" data-end=\"1843\" \/><a class=\"decorated-link\" href=\"https:\/\/patents.google.com\/patent\/US20200102274A1\/en\" target=\"_blank\" rel=\"noopener\" data-start=\"1845\" data-end=\"1897\">https:\/\/patents.google.com\/patent\/US20200102274A1\/en<\/a><\/p>\n<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p data-start=\"0\" data-end=\"438\"><strong data-start=\"0\" data-end=\"15\">5-Amino-1MQ<\/strong> ni peptid \u2013 in tudi po\u017eivilo ni. Gre za majhno molekulo <strong data-start=\"88\" data-end=\"106\">Zaviralec NNMT<\/strong> to prilagodi celi\u010dno knjigovodstvo va\u0161ega telesa, ne va\u0161ih \u017eivcev. S blokiranjem <strong data-start=\"173\" data-end=\"209\">nikotinamid N-metiltransferaza<\/strong>, prepre\u010duje, da bi se niacin (NAM) in metilne skupine prelivali v 1-MNA. Rezultat: ve\u010d <strong data-start=\"304\" data-end=\"312\" data-is-only-node=\"\">NAD\u207a<\/strong> za mitohondrijsko \u201cgospodinjenje\u201d in \u0161e ve\u010d <strong data-start=\"355\" data-end=\"362\">SAM<\/strong> za zdravo metilacijo \u2013 dva vira v ozadju, ki tiho upravljata z vsem.<\/p>\n<p data-start=\"440\" data-end=\"822\">Predstavljajte si kot ne\u017eno <strong data-start=\"464\" data-end=\"488\">presnovni uravnavalec<\/strong>. Ko je NNMT zmanj\u0161an, laboratorijski modeli ka\u017eejo <strong data-start=\"532\" data-end=\"553\">ma\u0161\u010dobne celice se kr\u010dijo<\/strong>, celularno <strong data-start=\"564\" data-end=\"586\">poraba energije<\/strong> znaki se okrepijo in vnetni hrup se umiri. Ne gre za preklop velikega stikala delovanja; gre za odstranjevanje peska iz celi\u010dnih zobnikov, tako da lahko poti, kot so <strong data-start=\"734\" data-end=\"759\">popravilo, ki ga vodijo sirtuini<\/strong> in <strong data-start=\"764\" data-end=\"785\">epigenetsko uravnavanje<\/strong> lahko bren\u010dijo tako, kot je treba.<\/p>\n<p data-start=\"824\" data-end=\"1173\">Zato 5-Amino-1MQ priteguje pozornost raziskovalcev: ena natan\u010dna tar\u010dna encimska to\u010dka, <strong data-start=\"902\" data-end=\"932\">vsesistemski valovni u\u010dinki<\/strong>\u2014od redoks statusa do preskrbe z lipidi \u2014brez delovanja kot hormon ali receptor agonist.<\/p>","protected":false},"featured_media":7622,"template":"","meta":{"_acf_changed":false,"ub_ctt_via":""},"product_brand":[],"product_cat":[52,46,45,51],"product_tag":[132,133],"class_list":["post-7605","product","type-product","status-publish","has-post-thumbnail","product_cat-anti-inflammatory-response-research-peptides","product_cat-peptides-for-longevity-research","product_cat-peptides-for-fat-metabolism-research","product_cat-peptides-for-weight-management-research","product_tag-peptide","product_tag-requires-aa-water","first","instock","shipping-taxable","purchasable","product-type-simple"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v22.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Buy 5-Amino-1MQ 5mg (99% Purity) - CellPeptides<\/title>\n<meta name=\"description\" content=\"5-Amino-1MQ 5mg for NAD+, NNMT inhibition and adipocyte research. 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