 {"id":7605,"date":"2025-12-03T15:21:59","date_gmt":"2025-12-03T15:21:59","guid":{"rendered":"https:\/\/cellpeptides.com\/?post_type=product&#038;p=7605"},"modified":"2026-06-09T03:12:55","modified_gmt":"2026-06-09T10:12:55","slug":"5-amino-1mq-5mg","status":"publish","type":"product","link":"https:\/\/cellpeptides.com\/fr\/product\/5-amino-1mq-5mg\/","title":{"rendered":"5-Amino-1MQ 5 mg"},"content":{"rendered":"<h2>What Is 5-Amino-1MQ &amp; Its Mechanism of Action?<\/h2>\n<p><strong data-start=\"0\" data-end=\"15\" data-is-only-node=\"\">5-Amino-1MQ<\/strong> (5-amino-1-methylquinolinium) is a small-molecule, cell-permeable <strong data-start=\"82\" data-end=\"138\">inhibitor of nicotinamide N-methyltransferase (NNMT) <\/strong>\u2014 the enzyme that methylates nicotinamide (NAM) to 1-methylnicotinamide (1-MNA) using S-adenosyl-methionine (SAM) as the methyl donor. By <strong data-start=\"275\" data-end=\"292\">blocking NNMT<\/strong>, 5-Amino-1MQ:<\/p>\n<ul>\n<li><strong data-start=\"310\" data-end=\"375\">prevents diversion of NAM away from the NAMPT salvage pathway<\/strong>, which can increase intracellular <strong data-start=\"410\" data-end=\"418\">NAD\u207a<\/strong> availability, and<\/li>\n<li><strong data-start=\"442\" data-end=\"486\">conserves the cellular methyl-donor pool<\/strong> (shifting the <strong data-start=\"501\" data-end=\"512\">SAM\/SAH<\/strong> balance), with downstream effects on epigenetic methylation and gene expression.<\/li>\n<\/ul>\n<p>At the enzyme level it binds within NNMT\u2019s <strong data-start=\"637\" data-end=\"657\">substrate pocket<\/strong> with high selectivity; at the cellular level this reprograms metabolic signaling (e.g., sirtuin-dependent pathways) and has been shown in vitro and in rodent studies to <strong data-start=\"827\" data-end=\"842\">lower 1-MNA<\/strong>, <strong data-start=\"844\" data-end=\"881\">reduce adipocyte lipogenesis\/size<\/strong>, and <strong data-start=\"887\" data-end=\"918\">increase energy expenditure<\/strong>. In short, 5-Amino-1MQ acts as a metabolic\/epigenetic \u201cnode\u201d by inhibiting NNMT, thereby impacting <strong data-start=\"1018\" data-end=\"1031\">NAD\u207a flux<\/strong> and <strong data-start=\"1036\" data-end=\"1061\">methylation potential<\/strong> rather than directly activating a receptor.<\/p>\n<p>&nbsp;<\/p>\n<h2>5-Amino-1MQ Effects on the Body &amp; Why It Matters?<\/h2>\n<p data-start=\"0\" data-end=\"499\">It blocks <strong data-start=\"74\" data-end=\"82\">NNMT<\/strong>, an enzyme that wastes niacin (NAM) and methyl groups, so your cells keep more <strong data-start=\"162\" data-end=\"170\">NAD\u207a<\/strong> for mitochondrial upkeep and more <strong data-start=\"205\" data-end=\"212\">SAM<\/strong> for healthy methylation. That upstream tweak can ripple through energy, fat storage, and cellular stress \u2014 less biochemical \u201cdrag,\u201d more efficient housekeeping. Most evidence so far is <strong data-start=\"396\" data-end=\"411\" data-is-only-node=\"\">preclinical<\/strong> (cells\/animals), but the story is consistent: free up resources &#8211; systems run smoother.<\/p>\n<p data-start=\"501\" data-end=\"536\"><strong data-start=\"501\" data-end=\"536\">What it may do:<\/strong><\/p>\n<ul data-start=\"537\" data-end=\"1315\">\n<li data-start=\"537\" data-end=\"688\">\n<p data-start=\"539\" data-end=\"688\"><strong data-start=\"539\" data-end=\"560\">Raise usable NAD\u207a<\/strong> \u2013 by stopping NAM from being siphoned off, it feeds the NAD\u207a salvage loop, supporting mitochondrial enzymes (e.g., sirtuins).<\/p>\n<\/li>\n<li data-start=\"689\" data-end=\"827\">\n<p data-start=\"691\" data-end=\"827\"><strong data-start=\"691\" data-end=\"723\">Preserve methyl donors (SAM)<\/strong> \u2013 less NNMT activity means a better SAM:SAH balance, which can steady <strong data-start=\"794\" data-end=\"808\">epigenetic<\/strong> gene regulation.<\/p>\n<\/li>\n<li data-start=\"828\" data-end=\"960\">\n<p data-start=\"830\" data-end=\"960\"><strong data-start=\"830\" data-end=\"854\">Shrink fat-cell size<\/strong> \u2013 adipocytes tend to store less and burn more, trimming hypertrophy (seen in rodent\/adipocyte studies).<\/p>\n<\/li>\n<li data-start=\"961\" data-end=\"1089\">\n<p data-start=\"963\" data-end=\"1089\"><strong data-start=\"963\" data-end=\"997\">Nudge metabolism toward \u201cburn\u201d<\/strong> \u2013 downstream of higher NAD\u207a\/sirtuins, cells often show higher energy expenditure signals.<\/p>\n<\/li>\n<li data-start=\"1090\" data-end=\"1205\">\n<p data-start=\"1092\" data-end=\"1205\"><strong data-start=\"1092\" data-end=\"1118\">Tame inflammatory tone<\/strong> \u2013 improved redox control and signaling can dial back some pro-inflammatory pathways.<\/p>\n<\/li>\n<li data-start=\"1206\" data-end=\"1315\">\n<p data-start=\"1208\" data-end=\"1315\"><strong data-start=\"1208\" data-end=\"1230\">Lower 1-MNA levels<\/strong> \u2013 a direct readout of NNMT inhibition; useful as a biochemical \u201cproof it\u2019s working.\u201d<\/p>\n<\/li>\n<\/ul>\n<p data-start=\"1317\" data-end=\"1401\"><em data-start=\"1317\" data-end=\"1324\">Note:<\/em> These effects come from early research, not medical claims or dosing advice.<\/p>\n<p>&nbsp;<\/p>\n<h2>5-Amino-1MQ Dosing protocol In-Vitro Research Fields<\/h2>\n<ul data-start=\"256\" data-end=\"731\">\n<li data-start=\"256\" data-end=\"399\">\n<p data-start=\"258\" data-end=\"399\"><strong data-start=\"258\" data-end=\"276\">Oral capsules:<\/strong> <strong data-start=\"277\" data-end=\"294\">50\u2013100 mg\/day<\/strong> (often split <strong data-start=\"308\" data-end=\"324\">25\u201350 mg BID<\/strong>); some quote <strong data-start=\"338\" data-end=\"355\" data-is-only-node=\"\">50\u2013150 mg\/day<\/strong> and \u201ccycles\u201d of ~8\u201312 weeks with breaks.<\/p>\n<\/li>\n<li data-start=\"400\" data-end=\"612\">\n<p data-start=\"402\" data-end=\"612\"><strong data-start=\"402\" data-end=\"441\">\u201cInjectable\u201d protocols sold online:<\/strong> <strong data-start=\"442\" data-end=\"460\">150\u2013600 \u00b5g\/day<\/strong> with step-up schedules over 4\u201312 weeks (note the <strong data-start=\"510\" data-end=\"523\">microgram<\/strong> units\u2014this conflicts with capsule <strong data-start=\"558\" data-end=\"564\" data-is-only-node=\"\">mg<\/strong> regimens and reflects nonstandard products).<\/p>\n<\/li>\n<\/ul>\n<p>Use our <a href=\"https:\/\/cellpeptides.com\/peptide-dosage-calculator\/\">peptide dosage calculator<\/a> in order to find out the correct dose for your model.<\/p>\n<h2><b>Why Choose CellPeptides for Your 5-Amino-1MQ Research?<\/b><\/h2>\n<p><span style=\"font-weight: 400;\">CellPeptides is an EU-based research chemical company who tries to live up to that exciting legacy. We provide pharmacological-grade SLU-PP-332 with the potential to form the basis for brand new discoveries.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">With us, you get:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">\u226599% purity \u2014 as pure as it gets, and completely ready for your ambitious study design.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Certificates of analysis from independent labs, so you can check purity and composition for yourself.\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Fast, global, insured, and <\/span><i><span style=\"font-weight: 400;\">safe<\/span><\/i><span style=\"font-weight: 400;\"> shipping. With tracking, of course.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Flexibility when it comes to payment. Don\u2019t like credit cards or bank transfers? We take crypto, too.\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">A knowledgeable support team that will get your questions answered \u2014 if there\u2019s a glitch with your order, but also if you\u2019d like to run your research design by us.<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">We handle the reliability (our 5-Amino-1MQ is synthesized in an EU-based WHO\/GMP and ISO 9001:2015 certified lab), so you get the compound you need to contribute to the future of science. Every time.<\/span><\/p>\n<h2><em><b>Scientific References<\/b><\/em><\/h2>\n<ul>\n<li data-start=\"50\" data-end=\"243\">\n<p data-start=\"52\" data-end=\"243\">Neelakantan H. et al. <strong data-start=\"74\" data-end=\"188\">Selective and membrane-permeable small-molecule NNMT inhibitors reverse high-fat diet\u2013induced obesity in mice.<\/strong><br data-start=\"188\" data-end=\"191\" \/><a class=\"decorated-link\" href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC5826726\/\" target=\"_blank\" rel=\"noopener\" data-start=\"193\" data-end=\"242\" data-is-only-node=\"\">https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC5826726\/<\/a><\/p>\n<\/li>\n<li data-start=\"245\" data-end=\"465\">\n<p data-start=\"247\" data-end=\"465\">Neelakantan H. et al. <strong data-start=\"269\" data-end=\"343\">Structure\u2013Activity Relationship for Small-Molecule Inhibitors of NNMT.<\/strong> <em data-start=\"344\" data-end=\"356\">J Med Chem<\/em> (SAR incl. 5-Amino-1MQ).<br data-start=\"381\" data-end=\"384\" \/><a class=\"decorated-link\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/28548833\/\" target=\"_blank\" rel=\"noopener\" data-start=\"386\" data-end=\"427\">https:\/\/pubmed.ncbi.nlm.nih.gov\/28548833\/<\/a> <span class=\"\" data-state=\"closed\"><span class=\"ms-1 inline-flex max-w-full items-center relative top-[-0.094rem] animate-[show_150ms_ease-in]\" data-testid=\"webpage-citation-pill\"><a class=\"flex h-4.5 overflow-hidden rounded-xl px-2 text-[9px] font-medium transition-colors duration-150 ease-in-out text-token-text-secondary! bg-[#F4F4F4]! dark:bg-[#303030]!\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/28548833\/\" target=\"_blank\" rel=\"noopener\"><span class=\"relative start-0 bottom-0 flex h-full w-full items-center\"><span class=\"flex h-4 w-full items-center justify-between overflow-hidden\"><span class=\"max-w-[15ch] grow truncate overflow-hidden text-center\">PubMed<\/span><\/span><\/span><\/a><\/span><\/span><\/p>\n<\/li>\n<li data-start=\"467\" data-end=\"648\">\n<p data-start=\"469\" data-end=\"648\">Sampson C.M. et al. <strong data-start=\"489\" data-end=\"541\">Combined NNMT inhibition and calorie restriction<\/strong> (microbiome &amp; metabolic effects; uses 5-Amino-1MQ).<br data-start=\"593\" data-end=\"596\" \/><a class=\"decorated-link\" href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7952898\/\" target=\"_blank\" rel=\"noopener\" data-start=\"598\" data-end=\"647\">https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7952898\/<\/a><\/p>\n<\/li>\n<li data-start=\"650\" data-end=\"850\">\n<p data-start=\"652\" data-end=\"850\">Dimet-Wiley A.L. et al. <strong data-start=\"676\" data-end=\"742\">NNMT inhibition mimics\/boosts exercise benefits in aged muscle<\/strong> (5-Amino-1MQ).<br data-start=\"757\" data-end=\"760\" \/><a class=\"decorated-link\" href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC11226645\/\" target=\"_blank\" rel=\"noopener\" data-start=\"762\" data-end=\"812\">https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC11226645\/<\/a> <span class=\"\" data-state=\"closed\"><span class=\"ms-1 inline-flex max-w-full items-center relative top-[-0.094rem] animate-[show_150ms_ease-in]\" data-testid=\"webpage-citation-pill\"><a class=\"flex h-4.5 overflow-hidden rounded-xl px-2 text-[9px] font-medium transition-colors duration-150 ease-in-out text-token-text-secondary! bg-[#F4F4F4]! dark:bg-[#303030]!\" href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC11226645\/\" target=\"_blank\" rel=\"noopener\"><span class=\"relative start-0 bottom-0 flex h-full w-full items-center\"><span class=\"flex h-4 w-full items-center justify-between overflow-hidden\"><span class=\"max-w-[15ch] grow truncate overflow-hidden text-center\">PMC<\/span><\/span><\/span><\/a><\/span><\/span><\/p>\n<\/li>\n<li data-start=\"852\" data-end=\"1062\">\n<p data-start=\"854\" data-end=\"1062\">Dimet-Wiley A.L. et al. <strong data-start=\"878\" data-end=\"932\">Reduced-calorie diet combined with NNMT inhibition<\/strong> (uses 5-Amino-1MQ).<br data-start=\"952\" data-end=\"955\" \/><a class=\"decorated-link\" href=\"https:\/\/www.nature.com\/articles\/s41598-021-03670-5\" target=\"_blank\" rel=\"noopener\" data-start=\"957\" data-end=\"1007\">https:\/\/www.nature.com\/articles\/s41598-021-03670-5<\/a> | PubMed: <a class=\"decorated-link\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35013352\/\" target=\"_blank\" rel=\"noopener\" data-start=\"1020\" data-end=\"1061\">https:\/\/pubmed.ncbi.nlm.nih.gov\/35013352\/<\/a><\/p>\n<\/li>\n<li data-start=\"1064\" data-end=\"1217\">\n<p data-start=\"1066\" data-end=\"1217\">Iyamu I.D. et al. <strong data-start=\"1084\" data-end=\"1121\">Mechanisms and inhibitors of NNMT<\/strong> (review; potency notes for 5-Amino-1MQ).<br data-start=\"1162\" data-end=\"1165\" \/><a class=\"decorated-link\" href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC8372200\/\" target=\"_blank\" rel=\"noopener\" data-start=\"1167\" data-end=\"1216\">https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC8372200\/<\/a><\/p>\n<\/li>\n<li data-start=\"1219\" data-end=\"1398\">\n<p data-start=\"1221\" data-end=\"1398\">Gao Y. et al. <strong data-start=\"1235\" data-end=\"1275\">NNMT: an emerging therapeutic target<\/strong> (review; SAR mentions 5-Amino-1MQ IC\u2085\u2080 \u2248 1.2 \u00b5M).<br data-start=\"1325\" data-end=\"1328\" \/><a class=\"decorated-link\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1359644621002427\" target=\"_blank\" rel=\"noopener\" data-start=\"1330\" data-end=\"1397\">https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1359644621002427<\/a><\/p>\n<\/li>\n<li data-start=\"1400\" data-end=\"1579\">\n<p data-start=\"1402\" data-end=\"1579\">Sun W.D. et al. <strong data-start=\"1418\" data-end=\"1457\">NNMT: a novel pharmaceutical target<\/strong> (Frontiers review, 2024).<br data-start=\"1483\" data-end=\"1486\" \/><a class=\"decorated-link\" href=\"https:\/\/www.frontiersin.org\/journals\/pharmacology\/articles\/10.3389\/fphar.2024.1410479\/full\" target=\"_blank\" rel=\"noopener\" data-start=\"1488\" data-end=\"1578\">https:\/\/www.frontiersin.org\/journals\/pharmacology\/articles\/10.3389\/fphar.2024.1410479\/full<\/a><\/p>\n<\/li>\n<li data-start=\"1581\" data-end=\"1729\">\n<p data-start=\"1583\" data-end=\"1729\">Li X.Y. et al. <strong data-start=\"1598\" data-end=\"1636\">NNMT as biomarker\/target in cancer<\/strong> (broad context; inhibitor landscape).<br data-start=\"1674\" data-end=\"1677\" \/><a class=\"decorated-link\" href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC9218565\/\" target=\"_blank\" rel=\"noopener\" data-start=\"1679\" data-end=\"1728\">https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC9218565\/<\/a><\/p>\n<\/li>\n<li data-start=\"1731\" data-end=\"1898\">\n<p data-start=\"1733\" data-end=\"1898\">Patent (methods &amp; data excerpts): <strong data-start=\"1767\" data-end=\"1819\">Quinoline-derived small-molecule NNMT inhibitors<\/strong> (incl. 5-Amino-1MQ).<br data-start=\"1840\" data-end=\"1843\" \/><a class=\"decorated-link\" href=\"https:\/\/patents.google.com\/patent\/US20200102274A1\/en\" target=\"_blank\" rel=\"noopener\" data-start=\"1845\" data-end=\"1897\">https:\/\/patents.google.com\/patent\/US20200102274A1\/en<\/a><\/p>\n<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p data-start=\"0\" data-end=\"438\"><strong data-start=\"0\" data-end=\"15\">5-Amino-1MQ<\/strong> ce n'est pas un peptide, et ce n'est pas non plus un stimulant. C'est une petite mol\u00e9cule <strong data-start=\"88\" data-end=\"106\">Inhibiteur de la NNMT<\/strong> cela ajuste la comptabilit\u00e9 de vos cellules, pas vos nerfs. En bloquant <strong data-start=\"173\" data-end=\"209\">nicotinamide N-m\u00e9thyltransf\u00e9rase<\/strong>, il emp\u00eache la niacine (NAM) et les groupes m\u00e9thyle d'\u00eatre d\u00e9tourn\u00e9s vers le 1-MNA. R\u00e9sultat : plus <strong data-start=\"304\" data-end=\"312\" data-is-only-node=\"\">NAD\u207a<\/strong> pour l\u201c\u201d entretien \u00bb mitochondrial et plus encore <strong data-start=\"355\" data-end=\"362\">SAM<\/strong> pour une m\u00e9thylation saine \u2014 deux ressources en amont qui r\u00e9gissent discr\u00e8tement l'ensemble.<\/p>\n<p data-start=\"440\" data-end=\"822\">Consid\u00e9rez cela comme un doux <strong data-start=\"464\" data-end=\"488\">r\u00e9\u00e9quilibreur m\u00e9tabolique<\/strong>. Lorsque l'expression de la NNMT est r\u00e9duite, les mod\u00e8les de laboratoire montrent <strong data-start=\"532\" data-end=\"553\">les adipocytes r\u00e9tr\u00e9cissent<\/strong>, cellulaire <strong data-start=\"564\" data-end=\"586\">d\u00e9pense \u00e9nerg\u00e9tique<\/strong> les indices augmentent et le bruit inflammatoire s'att\u00e9nue. Il ne s'agit pas d'actionner un grand interrupteur de performance, mais de retirer le sable des engrenages cellulaires pour que des voies telles que <strong data-start=\"734\" data-end=\"759\">r\u00e9paration guid\u00e9e par les sirtuines<\/strong> et <strong data-start=\"764\" data-end=\"785\">r\u00e9glage \u00e9pig\u00e9n\u00e9tique<\/strong> peuvent bourdonner comme ils le sont cens\u00e9s.<\/p>\n<p data-start=\"824\" data-end=\"1173\">C'est pourquoi le 5-Amino-1MQ retient l'attention des chercheurs : une cible enzymatique pr\u00e9cise, <strong data-start=\"902\" data-end=\"932\">effets d'entra\u00eenement \u00e0 l'\u00e9chelle du syst\u00e8me<\/strong>\u2014du statut r\u00e9dox \u00e0 la gestion des lipides\u2014sans agir comme une hormone ou un agoniste des r\u00e9cepteurs.<\/p>","protected":false},"featured_media":7622,"template":"","meta":{"_acf_changed":false,"ub_ctt_via":""},"product_brand":[],"product_cat":[52,46,45,51],"product_tag":[132,133],"class_list":["post-7605","product","type-product","status-publish","has-post-thumbnail","product_cat-anti-inflammatory-response-research-peptides","product_cat-peptides-for-longevity-research","product_cat-peptides-for-fat-metabolism-research","product_cat-peptides-for-weight-management-research","product_tag-peptide","product_tag-requires-aa-water","first","instock","shipping-taxable","purchasable","product-type-simple"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v22.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Buy 5-Amino-1MQ 5mg (99% Purity) - CellPeptides<\/title>\n<meta name=\"description\" content=\"5-Amino-1MQ 5mg for NAD+, NNMT inhibition and adipocyte research. 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