{"id":15058,"date":"2026-08-12T03:09:36","date_gmt":"2026-08-12T10:09:36","guid":{"rendered":"https:\/\/cellpeptides.com\/?post_type=product&#038;p=15058"},"modified":"2026-08-12T03:25:58","modified_gmt":"2026-08-12T10:25:58","slug":"buy-foxo4-dri-2mg","status":"publish","type":"product","link":"https:\/\/cellpeptides.com\/el\/product\/buy-foxo4-dri-2mg\/","title":{"rendered":"FOXO4-DRI 2mg"},"content":{"rendered":"<h2><span style=\"font-weight: 400;\">\u03a4\u03bf FOXO4-DRI \u03b5\u03af\u03bd\u03b1\u03b9 \u03ad\u03bd\u03b1 \u03c0\u03b5\u03c0\u03c4\u03af\u03b4\u03b9\u03bf \u03c0\u03bf\u03c5 \u03ad\u03c7\u03b5\u03b9 \u03bc\u03b5\u03bb\u03b5\u03c4\u03b7\u03b8\u03b5\u03af \u03b3\u03b9\u03b1 \u03c4\u03b9\u03c2 \u03c0\u03b9\u03b8\u03b1\u03bd\u03ad\u03c2 \u03c4\u03bf\u03c5 \u03b9\u03b4\u03b9\u03cc\u03c4\u03b7\u03c4\u03b5\u03c2 \u03c3\u03c4\u03b7\u03bd \u03b1\u03bd\u03c4\u03b9aging (\u03b1\u03bd\u03c4\u03b9\u03b3\u03ae\u03c1\u03b1\u03bd\u03c3\u03b7), \u03b5\u03b9\u03b4\u03b9\u03ba\u03ac \u03cc\u03c3\u03bf\u03bd \u03b1\u03c6\u03bf\u03c1\u03ac \u03c4\u03b7\u03bd \u03b1\u03c0\u03bf\u03bc\u03ac\u03ba\u03c1\u03c5\u03bd\u03c3\u03b7 \u03c4\u03c9\u03bd \u03b3\u03b7\u03c1\u03b1\u03c3\u03bc\u03ad\u03bd\u03c9\u03bd (senescent) \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd.<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">\u0391\u03c5\u03c4\u03cc \u03b5\u03af\u03bd\u03b1\u03b9 \u03ad\u03bd\u03b1 \u03c3\u03c5\u03bd\u03b8\u03b5\u03c4\u03b9\u03ba\u03cc \u03c0\u03b5\u03c0\u03c4\u03af\u03b4\u03b9\u03bf \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03bf\u03cd\u03bc\u03b5\u03bd\u03bf \u03b1\u03c0\u03cc 46 \u03b1\u03bc\u03b9\u03bd\u03bf\u03be\u03ad\u03b1, \u03b5\u03be \u03bf\u03bb\u03bf\u03ba\u03bb\u03ae\u03c1\u03bf\u03c5 \u03b1\u03c0\u03cc D-\u03b1\u03bc\u03b9\u03bd\u03bf\u03be\u03ad\u03b1 \u03c3\u03b5 \u03b1\u03bd\u03c4\u03af\u03c3\u03c4\u03c1\u03bf\u03c6\u03b7 \u03b1\u03bb\u03bb\u03b7\u03bb\u03bf\u03c5\u03c7\u03af\u03b1. \u03a0\u03b1\u03c1\u03ad\u03c7\u03b5\u03c4\u03b1\u03b9 \u03c9\u03c2 \u03bb\u03c5\u03bf\u03c6\u03b9\u03bb\u03bf\u03c0\u03bf\u03b9\u03b7\u03bc\u03ad\u03bd\u03b7 \u03c3\u03ba\u03cc\u03bd\u03b7 \u03b3\u03b9\u03b1 \u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03b7\u03c1\u03b9\u03b1\u03ba\u03ae \u03c7\u03c1\u03ae\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03b5\u03c1\u03b5\u03c5\u03bd\u03b7\u03c4\u03b9\u03ba\u03bf\u03cd\u03c2 \u03c3\u03ba\u03bf\u03c0\u03bf\u03cd\u03c2. <\/span><i><span style=\"font-weight: 400;\">\u03bc\u03cc\u03bd\u03bf<\/span><\/i><span style=\"font-weight: 400;\">. \u039a\u03c5\u03c1\u03af\u03c9\u03c2, \u03c4\u03bf \u03c0\u03b5\u03c0\u03c4\u03af\u03b4\u03b9\u03bf \u03bc\u03b5\u03bb\u03b5\u03c4\u03ac\u03c4\u03b1\u03b9 \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03b5\u03ba\u03bb\u03b5\u03ba\u03c4\u03b9\u03ba\u03ae \u03b1\u03c0\u03bf\u03bc\u03ac\u03ba\u03c1\u03c5\u03bd\u03c3\u03b7 \u03c4\u03c9\u03bd \u03b3\u03b7\u03c1\u03b1\u03c3\u03bc\u03ad\u03bd\u03c9\u03bd \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd, \u03ba\u03b1\u03b8\u03ce\u03c2 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03c3\u03c0\u03ac\u03c3\u03b5\u03b9 \u03c4\u03bf\u03bd \u03b4\u03b5\u03c3\u03bc\u03cc \u03bc\u03b5 \u03c4\u03b7\u03bd p53 \u03c3\u03c4\u03b1 \u03b3\u03b7\u03c1\u03ac\u03c3\u03ba\u03bf\u03bd\u03c4\u03b1 \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1, \u03b5\u03c0\u03b9\u03c4\u03c1\u03ad\u03c0\u03bf\u03bd\u03c4\u03ac\u03c2 \u03c4\u03bf\u03c5\u03c2 \u03bd\u03b1 \u03c0\u03b5\u03b8\u03ac\u03bd\u03bf\u03c5\u03bd. \u03a4\u03ce\u03c1\u03b1, \u03ad\u03c7\u03b5\u03c4\u03b5 \u03c5\u03c0\u03cc\u03c8\u03b7 \u03c3\u03b1\u03c2 \u03cc\u03c4\u03b9 \u03c4\u03bf FOXO4-DRI \u03b2\u03c1\u03af\u03c3\u03ba\u03b5\u03c4\u03b1\u03b9 \u03bc\u03cc\u03bd\u03bf \u03c3\u03b5 \u03c0\u03c1\u03bf\u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03cc \u03c3\u03c4\u03ac\u03b4\u03b9\u03bf \u03ba\u03b1\u03b9 \u03b4\u03b5\u03bd \u03c5\u03c0\u03ac\u03c1\u03c7\u03bf\u03c5\u03bd \u03b4\u03b5\u03b4\u03bf\u03bc\u03ad\u03bd\u03b1 \u03c3\u03b5 \u03b1\u03bd\u03b8\u03c1\u03ce\u03c0\u03bf\u03c5\u03c2. \u039a\u03b1\u03b9 \u03bf\u03b9 \u03c0\u03b5\u03c1\u03b9\u03c3\u03c3\u03cc\u03c4\u03b5\u03c1\u03bf\u03b9 \u03b1\u03c0\u03cc \u03c4\u03bf\u03c5\u03c2 \u03bc\u03b5\u03b3\u03ac\u03bb\u03bf\u03c5\u03c2 \u03b9\u03c3\u03c7\u03c5\u03c1\u03b9\u03c3\u03bc\u03bf\u03cd\u03c2 \u03c0\u03bf\u03c5 \u03b4\u03b9\u03b1\u03c4\u03c5\u03c0\u03ce\u03bd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03c7\u03b5\u03c4\u03b9\u03ba\u03ac \u03bc\u03b5 \u03c4\u03b7\u03bd \u03b1\u03bd\u03c4\u03b9\u2010\u03b3\u03ae\u03c1\u03b1\u03bd\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03c4\u03b7 \u03b8\u03b1\u03bd\u03ac\u03c4\u03c9\u03c3\u03b7 \u201c\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd-\u03b6\u03cc\u03bc\u03c0\u03b9\u201d \u03b5\u03af\u03bd\u03b1\u03b9 \u03b5\u03bb\u03b1\u03c6\u03c1\u03ce\u03c2 \u03b5\u03ba\u03c4\u03cc\u03c2 \u03c3\u03c4\u03cc\u03c7\u03bf\u03c5. \u03a4\u03bf \u03b2\u03b1\u03c3\u03b9\u03ba\u03cc \u03b5\u03cd\u03c1\u03b7\u03bc\u03b1 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03b5\u03c6\u03b1\u03c1\u03bc\u03bf\u03b3\u03ae \u03c4\u03bf\u03c5 \u03c3\u03b5 \u03c0\u03bf\u03bd\u03c4\u03af\u03ba\u03b9\u03b1 \u03ae\u03c4\u03b1\u03bd \u03cc\u03c4\u03b9 \u03b1\u03c0\u03bf\u03ba\u03b1\u03c4\u03ad\u03c3\u03c4\u03b7\u03c3\u03b5 \u03c4\u03b7 \u03c6\u03c5\u03c3\u03b9\u03ba\u03ae \u03ba\u03b1\u03c4\u03ac\u03c3\u03c4\u03b1\u03c3\u03b7, \u03c4\u03b7\u03bd \u03c0\u03c5\u03ba\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c4\u03bf\u03c5 \u03c4\u03c1\u03b9\u03c7\u03ce\u03bc\u03b1\u03c4\u03bf\u03c2 \u03ba\u03b1\u03b9 \u03c4\u03b7 \u03bd\u03b5\u03c6\u03c1\u03b9\u03ba\u03ae \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1 \u03c4\u03cc\u03c3\u03bf \u03c3\u03b5 \u03c0\u03bf\u03bd\u03c4\u03af\u03ba\u03b9\u03b1 \u03bc\u03b5 \u03c4\u03b1\u03c7\u03b5\u03af\u03b1 \u03b3\u03ae\u03c1\u03b1\u03bd\u03c3\u03b7 XpdTTD\/TTD \u03cc\u03c3\u03bf \u03ba\u03b1\u03b9 \u03c3\u03b5 \u03b7\u03bb\u03b9\u03ba\u03b9\u03c9\u03bc\u03ad\u03bd\u03b1 \u03c0\u03bf\u03bd\u03c4\u03af\u03ba\u03b9\u03b1 \u03c6\u03c5\u03c3\u03b9\u03ba\u03ae\u03c2 \u03b3\u03ae\u03c1\u03b1\u03bd\u03c3\u03b7\u03c2. \u039a\u03b1\u03bc\u03af\u03b1 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7 \u03b4\u03b5\u03bd \u03c4\u03bf \u03b1\u03bd\u03b1\u03c6\u03ad\u03c1\u03b5\u03b9 \u03c9\u03c2 \u03ba\u03ac\u03c4\u03b9 \u03c0\u03bf\u03c5 \u201c\u03b1\u03bd\u03c4\u03b9\u03c3\u03c4\u03c1\u03ad\u03c6\u03b5\u03b9 \u03c4\u03b7 \u03b3\u03ae\u03c1\u03b1\u03bd\u03c3\u03b7\u201d.\u201d<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u03a4\u03bf DRI \u03c3\u03b7\u03bc\u03b1\u03af\u03bd\u03b5\u03b9 D-\u03c1\u03b5\u03c4\u03c1\u03bf-\u03b9\u03bd\u03b2\u03ad\u03c1\u03c3\u03bf (D-retro-inverso). \u039f\u03c5\u03c3\u03b9\u03b1\u03c3\u03c4\u03b9\u03ba\u03ac \u03c3\u03b7\u03bc\u03b1\u03af\u03bd\u03b5\u03b9 \u03bc\u03b9\u03b1 \u03b1\u03bd\u03c4\u03af\u03c3\u03c4\u03c1\u03bf\u03c6\u03b7 \u03b1\u03bb\u03bb\u03b7\u03bb\u03bf\u03c5\u03c7\u03af\u03b1, \u03ae \u03bc\u03b9\u03b1 \u03ba\u03b1\u03c4\u03bf\u03c0\u03c4\u03c1\u03b9\u03ba\u03ae \u03b5\u03b9\u03ba\u03cc\u03bd\u03b1 \u03b1\u03bc\u03b9\u03bd\u03bf\u03be\u03ad\u03c9\u03bd. \u039f\u03b9 \u03b5\u03c0\u03b9\u03c3\u03c4\u03ae\u03bc\u03bf\u03bd\u03b5\u03c2 \u03b1\u03bd\u03c4\u03b9\u03c3\u03c4\u03c1\u03ad\u03c6\u03bf\u03c5\u03bd \u03c4\u03b9\u03c2 \u03b1\u03bb\u03bb\u03b7\u03bb\u03bf\u03c5\u03c7\u03af\u03b5\u03c2 \u03bc\u03b5 \u03b1\u03c5\u03c4\u03cc\u03bd \u03c4\u03bf\u03bd \u03c4\u03c1\u03cc\u03c0\u03bf \u03b5\u03c0\u03b5\u03b9\u03b4\u03ae, \u03b1\u03bd \u03ba\u03b1\u03b9 \u03c4\u03bf \u03c3\u03c5\u03bd\u03bf\u03bb\u03b9\u03ba\u03cc \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03c0\u03b1\u03c1\u03b1\u03bc\u03ad\u03bd\u03b5\u03b9 \u03c4\u03bf \u03af\u03b4\u03b9\u03bf, \u03b7 \u03b1\u03c0\u03bf\u03b4\u03cc\u03bc\u03b7\u03c3\u03b7 \u03b5\u03c0\u03b9\u03b2\u03c1\u03b1\u03b4\u03cd\u03bd\u03b5\u03c4\u03b1\u03b9 \u03b1\u03be\u03b9\u03bf\u03c3\u03b7\u03bc\u03b5\u03af\u03c9\u03c4\u03b1. \u039c\u03b5 \u03ac\u03bb\u03bb\u03b1 \u03bb\u03cc\u03b3\u03b9\u03b1, \u03c4\u03b1 \u03c0\u03b5\u03c0\u03c4\u03af\u03b4\u03b9\u03b1 L-\u03b1\u03bc\u03b9\u03bd\u03bf\u03be\u03ad\u03c9\u03bd \u03b4\u03b9\u03b1\u03c3\u03c0\u03ce\u03bd\u03c4\u03b1\u03b9 \u03b3\u03c1\u03ae\u03b3\u03bf\u03c1\u03b1 \u03b1\u03c0\u03cc \u03c4\u03b9\u03c2 \u03c0\u03c1\u03c9\u03c4\u03b5\u03ac\u03c3\u03b5\u03c2, \u03b5\u03bd\u03ce \u03b1\u03c5\u03c4\u03ae \u03b7 \u03c4\u03b1\u03ba\u03c4\u03b9\u03ba\u03ae \u03c4\u03b7\u03c2 \u03ba\u03b1\u03c4\u03bf\u03c0\u03c4\u03c1\u03b9\u03ba\u03ae\u03c2 \u03b5\u03b9\u03ba\u03cc\u03bd\u03b1\u03c2\/\u03b1\u03bd\u03c4\u03af\u03c3\u03c4\u03c1\u03bf\u03c6\u03b7\u03c2 \u03b1\u03bb\u03bb\u03b7\u03bb\u03bf\u03c5\u03c7\u03af\u03b1\u03c2 \u03b4\u03b9\u03b1\u03c4\u03b7\u03c1\u03b5\u03af \u03c4\u03b7\u03bd \u03c4\u03bf\u03c0\u03bf\u03bb\u03bf\u03b3\u03af\u03b1 \u03c4\u03b7\u03c2 \u03c0\u03bb\u03b5\u03c5\u03c1\u03b9\u03ba\u03ae\u03c2 \u03b1\u03bb\u03c5\u03c3\u03af\u03b4\u03b1\u03c2 (\u03ce\u03c3\u03c4\u03b5 \u03bd\u03b1 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03b5\u03be\u03b1\u03ba\u03bf\u03bb\u03bf\u03c5\u03b8\u03b5\u03af \u03bd\u03b1 \u03c3\u03c5\u03bd\u03b4\u03ad\u03b5\u03c4\u03b1\u03b9 \u03ba\u03b1\u03bd\u03bf\u03bd\u03b9\u03ba\u03ac), \u03b1\u03bd\u03c4\u03b9\u03c3\u03c4\u03ad\u03ba\u00e1ndose \u03c0\u03b1\u03c1\u03ac\u03bb\u03bb\u03b7\u03bb\u03b1 \u03c3\u03c4\u03b7\u03bd \u03b1\u03c0\u03bf\u03b4\u03cc\u03bc\u03b7\u03c3\u03b7.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u0397 \u03c0\u03b5\u03c1\u03b9\u03bf\u03c7\u03ae \u03b1\u03bb\u03bb\u03b7\u03bb\u03b5\u03c0\u03af\u03b4\u03c1\u03b1\u03c3\u03b7\u03c2 p53 \u03c4\u03b7\u03c2 \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7\u03c2 FOXO4 \u03bc\u03b5\u03bb\u03b5\u03c4\u03ae\u03b8\u03b7\u03ba\u03b5 \u03ba\u03b1\u03b9 \u03b7 \u03c0\u03b1\u03c1\u03b1\u03bb\u03bb\u03b1\u03b3\u03ae DRI \u03b1\u03c5\u03c4\u03bf\u03cd \u03c4\u03bf\u03c5 \u03c0\u03b5\u03c0\u03c4\u03b9\u03b4\u03af\u03bf\u03c5 \u03c0\u03b1\u03c1\u03ae\u03c7\u03b8\u03b7 \u03b1\u03c0\u03cc \u03c4\u03bf\u03bd Baar \u03ba\u03b1\u03b9 \u03c4\u03bf\u03c5\u03c2 \u03c3\u03c5\u03bd\u03b5\u03c1\u03b3\u03ac\u03c4\u03b5\u03c2 \u03c4\u03bf\u03c5 \u03c3\u03c4\u03bf \u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03ae\u03c1\u03b9\u03bf \u03c4\u03bf\u03c5 de Keizer (Cell, 2017). \u03a4\u03bf \u03c0\u03b5\u03c0\u03c4\u03af\u03b4\u03b9\u03bf \u03b4\u03b9\u03b1\u03b8\u03ad\u03c4\u03b5\u03b9 \u03bc\u03b9\u03b1 \u03bf\u03c5\u03c1\u03ac \u03b4\u03b9\u03b5\u03af\u03c3\u03b4\u03c5\u03c3\u03b7\u03c2 \u03c3\u03c4\u03b1 \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03b7 \u03bf\u03c0\u03bf\u03af\u03b1 \u03c4\u03bf\u03c5 \u03b5\u03c0\u03b9\u03c4\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03b4\u03b9\u03b1\u03c0\u03b5\u03c1\u03bd\u03ac \u03c4\u03b9\u03c2 \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03ad\u03c2 \u03bc\u03b5\u03bc\u03b2\u03c1\u03ac\u03bd\u03b5\u03c2.<\/span><\/p>\n<h2><span style=\"font-weight: 400;\">\u03a0\u03ce\u03c2 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03b5\u03af \u03c4\u03bf FOXO4-DRI;<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">\u03a0\u03bf\u03bb\u03bb\u03b1 \u03b1\u03c0\u03bf \u03bf\u03c3\u03b1 \u03ba\u03b1\u03bd\u03bf\u03c5\u03bd \u03c4\u03b1 \u03c0\u03b5\u03c0\u03c4\u03b9\u03b4\u03b9\u03b1 \u03c3\u03c5\u03bd\u03bf\u03c8\u03b9\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03c4\u03bf\u03c5\u03c2 \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03b5\u03b9\u03c2. \u039a\u03b1\u03b9 \u03b1\u03c5\u03c4\u03bf \u03b9\u03c3\u03c7\u03c5\u03b5\u03b9 \u03ba\u03b1\u03b9 \u03b5\u03b4\u03c9. \u0391\u03bb\u03bb\u03b1 \u03b1\u03c2 \u03ba\u03b1\u03bd\u03bf\u03c5\u03bc\u03b5 \u03b5\u03bd\u03b1 \u03b2\u03b7\u03bc\u03b1 \u03c0\u03b9\u03c3\u03c9 \u03c0\u03c1\u03c9\u03c4\u03b1 \u03b1\u03c0' \u03bf\u03bb\u03b1.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u03a4\u03b1 \u03b3\u03b7ras\u03bc\u03ad\u03bd\u03b1 \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03bf\u03bd\u03bf\u03bc\u03ac\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b3\u03b7\u03c1\u03b1\u03c3\u03bc\u03ad\u03bd\u03b1 \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1. \u0391\u03c5\u03c4\u03ac \u03c4\u03b1 \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03ad\u03c7\u03bf\u03c5\u03bd \u03c3\u03c4\u03b1\u03bc\u03b1\u03c4\u03ae\u03c3\u03b5\u03b9 \u03bd\u03b1 \u03b4\u03b9\u03b1\u03b9\u03c1\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9, \u03ad\u03c7\u03bf\u03c5\u03bd \u03bc\u03b5\u03b3\u03ac\u03bb\u03bf \u03bc\u03ad\u03b3\u03b5\u03b8\u03bf\u03c2 \u03ba\u03b1\u03b9 \u03c3\u03c5\u03c7\u03bd\u03ac \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03bd \u03bd\u03b1 \u03b1\u03c0\u03b5\u03bb\u03b5\u03c5\u03b8\u03b5\u03c1\u03ce\u03c3\u03bf\u03c5\u03bd \u03b5\u03c0\u03b9\u03b2\u03bb\u03b1\u03b2\u03b5\u03af\u03c2 \u03c6\u03bb\u03b5\u03b3\u03bc\u03bf\u03bd\u03ce\u03b4\u03b5\u03b9\u03c2 \u03c7\u03b7\u03bc\u03b9\u03ba\u03ad\u03c2 \u03bf\u03c5\u03c3\u03af\u03b5\u03c2 \u03ba\u03b1\u03b9 \u03b1\u03ba\u03cc\u03bc\u03b7 \u03ba\u03b1\u03b9 \u03bd\u03b1 \u03b2\u03bb\u03ac\u03c8\u03bf\u03c5\u03bd \u03c4\u03bf\u03c5\u03c2 \u03b3\u03cd\u03c1\u03c9 \u03b9\u03c3\u03c4\u03bf\u03cd\u03c2. \u0391\u03c5\u03c4\u03ac \u03c4\u03b1 \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03c3\u03c5\u03c3\u03c3\u03c9\u03c1\u03b5\u03cd\u03bf\u03c5\u03bd \u03bc\u03b9\u03b1 \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7 \u03c0\u03bf\u03c5 \u03bf\u03bd\u03bf\u03bc\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 FOXO4. \u0395\u03c0\u03af\u03c3\u03b7\u03c2, \u03cc\u03c4\u03b1\u03bd \u03c4\u03b1 \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03c5\u03c6\u03af\u03c3\u03c4\u03b1\u03bd\u03c4\u03b1\u03b9 \u03b3\u03ae\u03c1\u03b1\u03bd\u03c3\u03b7 \u03c0\u03bf\u03c5 \u03c0\u03c1\u03bf\u03ba\u03b1\u03bb\u03b5\u03af\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03b1\u03ba\u03c4\u03b9\u03bd\u03bf\u03b2\u03bf\u03bb\u03af\u03b1 (\u03cc\u03c0\u03c9\u03c2 \u03ba\u03b1\u03c4\u03ac \u03c4\u03b7 \u03b4\u03b9\u03ac\u03c1\u03ba\u03b5\u03b9\u03b1 \u03c4\u03b7\u03c2 \u03c7\u03b7\u03bc\u03b5\u03b9\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2), \u03c3\u03c5\u03c3\u03c3\u03c9\u03c1\u03b5\u03cd\u03b5\u03c4\u03b1\u03b9 \u03c0\u03bf\u03bb\u03cd FOXO4 \u03bc\u03ad\u03c3\u03b1 \u03c3\u03b5 \u03b1\u03c5\u03c4\u03ac. \u0397 \u03b4\u03bf\u03c5\u03bb\u03b5\u03b9\u03ac \u03c4\u03bf\u03c5 FOXO4 \u03b5\u03af\u03bd\u03b1\u03b9 \u03bd\u03b1 \u03b1\u03c0\u03bf\u03c4\u03c1\u03ad\u03c0\u03b5\u03b9 \u03c4\u03b7\u03bd \u03b1\u03c0\u03cc\u03c0\u03c4\u03c9\u03c3\u03b7 \u03c3\u03b5 \u03b1\u03c5\u03c4\u03ac \u03c4\u03b1 \u03b3\u03b7\u03c1\u03b1\u03c3\u03bc\u03ad\u03bd\u03b1 \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1. \u0395\u03ac\u03bd \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03c3\u03b1\u03c4\u03b5 \u03bd\u03b1 \u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03b5\u03af\u03bb\u03b5\u03c4\u03b5 \u03c4\u03b7\u03bd \u03ad\u03ba\u03c6\u03c1\u03b1\u03c3\u03b7 \u03c4\u03bf\u03c5 FOXO4, \u03b8\u03b1 \u03b2\u03bb\u03ad\u03c0\u03b1\u03c4\u03b5 \u03c6\u03c5\u03c3\u03b9\u03ba\u03ac \u03c0\u03b5\u03c1\u03b9\u03c3\u03c3\u03cc\u03c4\u03b5\u03c1\u03b1 \u03b1\u03c0\u03cc \u03b1\u03c5\u03c4\u03ac \u03c4\u03b1 \u03b3\u03b7\u03c1\u03b1\u03c3\u03bc\u03ad\u03bd\u03b1 \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03bd\u03b1 \u03c0\u03b5\u03b8\u03b1\u03af\u03bd\u03bf\u03c5\u03bd.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u0391\u03c5\u03c4\u03cc \u03c0\u03bf\u03c5 \u03ba\u03ac\u03bd\u03b5\u03b9 \u03c4\u03bf FOXO4 \u03bc\u03ad\u03c3\u03b1 \u03c3\u03c4\u03bf \u03b3i\u03c1\u03b1\u03c3\u03bc\u03ad\u03bd\u03bf \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03bf \u03b5\u03af\u03bd\u03b1\u03b9 \u03bd\u03b1 \u03c3\u03c5\u03b3\u03ba\u03c1\u03b1\u03c4\u03b5\u03af \u03c4\u03b7\u03bd p53 \u2013 \u03bc\u03b9\u03b1 \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7 \u03c0\u03bf\u03c5 \u03ad\u03c7\u03b5\u03b9 \u03c0\u03bf\u03bb\u03bb\u03ad\u03c2 \u03b5\u03c5\u03b8\u03cd\u03bd\u03b5\u03c2, \u03bc\u03af\u03b1 \u03b5\u03ba \u03c4\u03c9\u03bd \u03bf\u03c0\u03bf\u03af\u03c9\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03bd\u03b1 \u03c3\u03c4\u03ad\u03bb\u03bd\u03b5\u03b9 \u03c3\u03ae\u03bc\u03b1\u03c4\u03b1 \u03c5\u03c0\u03ad\u03c1 \u03c4\u03bf\u03c5 \u03b8\u03b1\u03bd\u03ac\u03c4\u03bf\u03c5 \u03ce\u03c3\u03c4\u03b5 \u03c4\u03bf \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03bf \u03bd\u03b1 \u03c0\u03b5\u03b8\u03ac\u03bd\u03b5\u03b9. \u038c\u03c3\u03bf \u03bc\u03b9\u03b1 \u03c0\u03bf\u03c3\u03cc\u03c4\u03b7\u03c4\u03b1 FOXO4 \u03c3\u03c5\u03b3\u03ba\u03c1\u03b1\u03c4\u03b5\u03af \u03cc\u03bb\u03b7 \u03b1\u03c5\u03c4\u03ae \u03c4\u03b7\u03bd p53 \u03bc\u03ad\u03c3\u03b1 \u03c3\u03c4\u03b1 \u03b3\u03b7\u03c1\u03b1\u03c3\u03bc\u03ad\u03bd\u03b1 \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1, \u03b1\u03c5\u03c4\u03ac \u03b4\u03b5\u03bd \u03c0\u03c1\u03cc\u03ba\u03b5\u03b9\u03c4\u03b1\u03b9 \u03bd\u03b1 \u03c0\u03b5\u03b8\u03ac\u03bd\u03bf\u03c5\u03bd.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u03a4\u03bf \u03c3\u03c5\u03bd\u03b8\u03b5\u03c4\u03b9\u03ba\u03cc \u03c0\u03b5\u03c0\u03c4\u03af\u03b4\u03b9\u03bf \u03c0\u03bf\u03c5 \u03bf\u03bd\u03bf\u03bc\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 FOXO4-DRI \u03b3\u03b9\u03b1 \u03c4\u03bf \u03bf\u03c0\u03bf\u03af\u03bf \u03c3\u03c5\u03b6\u03b7\u03c4\u03ac\u03bc\u03b5 \u03b5\u03b4\u03ce \u03b1\u03bd\u03c4\u03b1\u03b3\u03c9\u03bd\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03b3\u03b9\u03b1 \u03c4\u03b7 \u03b8\u03ad\u03c3\u03b7 \u03c3\u03cd\u03bd\u03b4\u03b5\u03c3\u03b7\u03c2. \u03a0\u03c1\u03bf\u03c3\u03c0\u03b1\u03b8\u03b5\u03af \u03bd\u03b1 \u03c3\u03c5\u03bd\u03b4\u03b5\u03b8\u03b5\u03af \u03c0\u03c1\u03ce\u03c4\u03b1 \u03bc\u03b5 \u03c4\u03b7\u03bd p53, \u03c0\u03c1\u03b9\u03bd \u03c0\u03c1\u03bf\u03bb\u03ac\u03b2\u03b5\u03b9 \u03b7 \u03af\u03b4\u03b9\u03b1 \u03b7 FOXO4 \u03c4\u03bf\u03c5 \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03bf\u03c5. \u039a\u03b1\u03b9 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03c1\u03ba\u03b5\u03c4\u03ac \u03b5\u03c0\u03b9\u03c4\u03c5\u03c7\u03b7\u03bc\u03ad\u03bd\u03bf \u03c3\u03b5 \u03b1\u03c5\u03c4\u03cc. \u03a0\u03b1\u03c1\u03b1\u03c4\u03b7\u03c1\u03ae\u03b8\u03b7\u03ba\u03b5 \u03cc\u03c4\u03b9 \u03c4\u03bf \u03c0\u03b5\u03c0\u03c4\u03af\u03b4\u03b9\u03bf \u03ad\u03c7\u03b5\u03b9 \u03c5\u03c8\u03b7\u03bb\u03cc\u03c4\u03b5\u03c1\u03b7 \u03c3\u03c5\u03b3\u03b3\u03ad\u03bd\u03b5\u03b9\u03b1 \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd p53. \u03a4\u03ce\u03c1\u03b1, \u03ba\u03b1\u03b8\u03ce\u03c2 \u03ad\u03c7\u03bf\u03c5\u03bc\u03b5 \u03b1\u03bd\u03c4\u03b9\u03baatast\u03ae\u03c3\u03b5\u03b9 \u03ad\u03bd\u03b1\u03bd \u03c6\u03c5\u03c3\u03b9\u03ba\u03cc \u03b4\u03b5\u03c3\u03bc\u03cc FOXO4\/p53 \u03bc\u03b5 \u03ad\u03bd\u03b1\u03bd \u03b4\u03b5\u03c3\u03bc\u03cc FOXO4-DRI\/p53, \u03ad\u03c7\u03bf\u03c5\u03bc\u03b5 \u03bf\u03c5\u03c3\u03b9\u03b1\u03c3\u03c4\u03b9\u03ba\u03ac \u03b1\u03c0\u03bf\u03c4\u03c1\u03ad\u03c8\u03b5\u03b9 \u03c4\u03b7 \u03c3\u03cd\u03bd\u03b4\u03b5\u03c3\u03b7 \u03c4\u03b7\u03c2 p53 \u03c3\u03c4\u03bf\u03bd \u03c0\u03c5\u03c1\u03ae\u03bd\u03b1. \u039c\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b2\u03b3\u03b5\u03b9 \u03ad\u03be\u03c9 \u03ba\u03b1\u03b9 \u03bd\u03b1 \u03c3\u03c4\u03b5\u03af\u03bb\u03b5\u03b9 \u03c3\u03ae\u03bc\u03b1\u03c4\u03b1 \u03c0\u03c1\u03bf\u03b3\u03c1\u03b1\u03bc\u03bc\u03b1\u03c4\u03b9\u03c3\u03bc\u03ad\u03bd\u03bf\u03c5 \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03bf\u03cd \u03b8\u03b1\u03bd\u03ac\u03c4\u03bf\u03c5, \u03b5\u03c0\u03b5\u03b9\u03b4\u03ae \u03c4\u03bf \u03c0\u03b5\u03c0\u03c4\u03af\u03b4\u03b9\u03bf FOXO4-DRI \u03b4\u03b5\u03bd \u03c4\u03bf \u03b1\u03bd\u03b1\u03c3\u03c4\u03ad\u03bb\u03bb\u03b5\u03b9 \u03b1\u03c5\u03c4\u03cc.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u0388\u03c4\u03c3\u03b9, \u03b1\u03c0\u03bb\u03ce\u03c2 \u03c0\u03c1\u03bf\u03c3\u03b4\u03b5\u03ba\u03cc\u03bc\u03b5\u03bd\u03bf \u03c3\u03c4\u03b7\u03bd p53 \u03c0\u03c1\u03b9\u03bd \u03c0\u03c1\u03bf\u03bb\u03ac\u03b2\u03b5\u03b9 \u03b7 \u03c6\u03c5\u03c3\u03b9\u03ba\u03ae FOXO4, \u03c4\u03bf \u03c0\u03b5\u03c0\u03c4\u03af\u03b4\u03b9\u03bf \u03b5\u03c0\u03b9\u03c4\u03c1\u03ad\u03c0\u03b5\u03b9 \u03c3\u03c4\u03b1 \u03b3\u03b5\u03c1\u03b1\u03c3\u03bc\u03ad\u03bd\u03b1 \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03bd\u03b1 \u03c0\u03b5\u03b8\u03ac\u03bd\u03bf\u03c5\u03bd. \u039a\u03b1\u03b8\u03ce\u03c2 \u03b7 p53 \u03b4\u03b5\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03c0\u03c1\u03bf\u03c3\u03b4\u03b5\u03bc\u03ad\u03bd\u03b7 \u03c3\u03c4\u03b7\u03bd \u03c6\u03c5\u03c3\u03b9\u03ba\u03ae FOXO4 (\u03b7 \u03bf\u03c0\u03bf\u03af\u03b1 \u03c4\u03b7\u03bd \u03ba\u03c1\u03b1\u03c4\u03ac \u03c3\u03c4\u03bf\u03bd \u03c0\u03c5\u03c1\u03ae\u03bd\u03b1), \u03bc\u03b5\u03c4\u03b1\u03ba\u03b9\u03bd\u03b5\u03af\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b1 \u03bc\u03b9\u03c4\u03bf\u03c7\u03cc\u03bd\u03b4\u03c1\u03b9\u03b1 \u03ba\u03b1\u03b9 \u03c0\u03c5\u03c1\u03bf\u03b4\u03bf\u03c4\u03b5\u03af \u03c4\u03b7\u03bd \u03b1\u03c0\u03cc\u03c0\u03c4\u03c9\u03c3\u03b7. \u0391\u03c5\u03c4\u03cc \u03bc\u03b5 \u03c4\u03b7 \u03c3\u03b5\u03b9\u03c1\u03ac \u03c4\u03bf\u03c5 \u03b5\u03be\u03b1\u03bb\u03b5\u03af\u03c6\u03b5\u03b9 \u03c0\u03bb\u03ae\u03c1\u03c9\u03c2 \u03c4\u03bf \u03b3\u03b5\u03c1\u03b1\u03c3\u03bc\u03ad\u03bd\u03bf \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03bf.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u0391\u03c5\u03c4\u03cc \u03c4\u03bf \u03c0\u03b5\u03c0\u03c4\u03af\u03b4\u03b9\u03bf \u03b5\u03af\u03bd\u03b1\u03b9 \u03b5\u03ba\u03bb\u03b5\u03ba\u03c4\u03b9\u03ba\u03cc \u03b1\u03c0\u03cc \u03c4\u03b7 \u03c6\u03cd\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03b5\u03c0\u03b5\u03b9\u03b4\u03ae \u03c4\u03bf \u03af\u03b4\u03b9\u03bf \u03c4\u03bf FOXO4 \u03b2\u03c1\u03af\u03c3\u03ba\u03b5\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03c7\u03b1\u03bc\u03b7\u03bb\u03ac \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 \u03c3\u03c4\u03b1 \u03c0\u03b5\u03c1\u03b9\u03c3\u03c3\u03cc\u03c4\u03b5\u03c1\u03b1 \u03c5\u03b3\u03b9\u03ae \u03b5\u03bd\u03ae\u03bb\u03b9\u03ba\u03b1 \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1. \u0395\u03af\u03bd\u03b1\u03b9 \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03bf \u03bc\u03cc\u03bd\u03bf \u03c3\u03c4\u03b1 \u03b3\u03b7\u03c1\u03b1\u03c3\u03bc\u03ad\u03bd\u03b1.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">\u0397 \u03b1\u03bb\u03bb\u03b7\u03bb\u03b5\u03c0\u03af\u03b4\u03c1\u03b1\u03c3\u03b7 FOXO4-p53<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">\u0393\u03b9\u03b1\u03c4\u03af \u03c4\u03b1 \u03ba\u03b1\u03c4\u03b5\u03c3\u03c4\u03c1\u03b1\u03bc\u03bc\u03ad\u03bd\u03b1 \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03b1\u03c1\u03bd\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03bd\u03b1 \u03c0\u03b5\u03b8\u03ac\u03bd\u03bf\u03c5\u03bd; \u039a\u03b1\u03bd\u03bf\u03bd\u03b9\u03ba\u03ac, \u03b7 \u03c3\u03c5\u03c3\u03c3\u03c9\u03c1\u03b5\u03c5\u03bc\u03ad\u03bd\u03b7 \u03b2\u03bb\u03ac\u03b2\u03b7 \u03c3\u03c4\u03bf DNA \u03c9\u03b8\u03b5\u03af \u03ad\u03bd\u03b1 \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03bf \u03b5\u03af\u03c4\u03b5 \u03c0\u03c1\u03bf\u03c2 \u03c4\u03b7\u03bd \u03b1\u03c0\u03cc\u03c0\u03c4\u03c9\u03c3\u03b7 \u03b5\u03af\u03c4\u03b5 \u03c0\u03c1\u03bf\u03c2 \u03c4\u03b7 \u03b3\u03ae\u03c1\u03b1\u03bd\u03c3\u03b7. \u03a4\u03b1 \u03b3\u03b5\u03c1\u03b1\u03c3\u03bc\u03ad\u03bd\u03b1 \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03ad\u03c7\u03bf\u03c5\u03bd \u03ba\u03ac\u03bd\u03b5\u03b9 \u03c4\u03b7 \u03b4\u03b5\u03cd\u03c4\u03b5\u03c1\u03b7 \u03b5\u03c0\u03b9\u03bb\u03bf\u03b3\u03ae \u03ba\u03b1\u03b9 \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03c3\u03c5\u03bd\u03b5\u03c7\u03af\u03c3\u03bf\u03c5\u03bd \u03bd\u03b1 \u03c5\u03c0\u03b5\u03c1\u03b1\u03c3\u03c0\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b1\u03c5\u03c4\u03ae \u03c4\u03b7\u03bd \u03b5\u03c0\u03b9\u03bb\u03bf\u03b3\u03ae, \u03bf\u03c0\u03cc\u03c4\u03b5 \u03c3\u03c5\u03bd\u03b5\u03c7\u03af\u03b6\u03bf\u03c5\u03bd \u03bd\u03b1 \u03b6\u03bf\u03c5\u03bd. \u039c\u03b5 \u03ac\u03bb\u03bb\u03bf \u03c4\u03c1\u03cc\u03c0\u03bf \u03c3\u03ba\u03ad\u03c8\u03b7\u03c2, \u03b1\u03c5\u03c4\u03ae \u03b5\u03af\u03bd\u03b1\u03b9 \u03b7 \u03b1\u03bd\u03c4\u03af\u03c3\u03c4\u03b1\u03c3\u03b7 \u03c3\u03c4\u03b7\u03bd \u03b1\u03c0\u03cc\u03c0\u03c4\u03c9\u03c3\u03b7. \u0391\u03c5\u03c4\u03ae \u03b7 \u03b1\u03bd\u03c4\u03af\u03c3\u03c4\u03b1\u03c3\u03b7 \u03c3\u03c5\u03bc\u03b2\u03b1\u03af\u03bd\u03b5\u03b9 \u03bc\u03ad\u03c3\u03c9 \u03c0\u03bf\u03bb\u03bb\u03ce\u03bd \u03c0\u03c1\u03b1\u03b3\u03bc\u03ac\u03c4\u03c9\u03bd. \u0395\u03af\u03bd\u03b1\u03b9 \u03ad\u03c4\u03bf\u03b9\u03bc\u03b1 \u03bd\u03b1 \u03c0\u03b5\u03b8\u03ac\u03bd\u03bf\u03c5\u03bd \u03b1\u03bb\u03bb\u03ac \u03c3\u03c5\u03bd\u03b5\u03c7\u03af\u03b6\u03bf\u03c5\u03bd \u03bd\u03b1 \u03ba\u03c1\u03b1\u03c4\u03b9\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9. \u0397 \u03b1\u03c0\u03bf\u03bc\u03cc\u03bd\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 p53 \u03b1\u03c0\u03cc \u03c4\u03bf FOXO4 \u03b5\u03af\u03bd\u03b1\u03b9 \u03ad\u03bd\u03b1\u03c2 \u03b1\u03c0\u03cc \u03c4\u03bf\u03c5\u03c2 \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03bf\u03cd\u03c2 \u03c0\u03bf\u03c5 \u03ba\u03ac\u03bd\u03bf\u03c5\u03bd \u03b1\u03c5\u03c4\u03cc \u03c4\u03bf \u03ba\u03c1\u03ac\u03c4\u03b7\u03bc\u03b1.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u03a6\u03c5\u03c3\u03b9\u03ba\u03ac, \u03c4\u03bf FOXO4 \u03b2\u03c1\u03af\u03c3\u03ba\u03b5\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03b1 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 \u03c3\u03c4\u03b1 \u03b3\u03b7\u03c1\u03b1\u03c3\u03bc\u03ad\u03bd\u03b1 \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03ba\u03b1\u03b9 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03af \u03ba\u03c1\u03af\u03c3\u03b9\u03bc\u03bf \u03c3\u03c5\u03c3\u03c4\u03b1\u03c4\u03b9\u03ba\u03cc \u03b3\u03b9\u03b1 \u03c4\u03b7 \u03b4\u03b9\u03b1\u03c4\u03ae\u03c1\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03ae \u03b2\u03b9\u03c9\u03c3\u03b9\u03bc\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2. \u03a3\u03c5\u03b3\u03ba\u03c1\u03b1\u03c4\u03b5\u03af \u03c4\u03bf p53 \u03c3\u03c4\u03bf\u03bd \u03c0\u03c5\u03c1\u03ae\u03bd\u03b1, \u03c4\u03bf \u03bf\u03c0\u03bf\u03af\u03bf \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03b5\u03c4\u03b9\u03ba\u03ac \u03b8\u03b1 \u03ad\u03c3\u03c4\u03b5\u03bb\u03bd\u03b5 \u03c3\u03ae\u03bc\u03b1 \u03b3\u03b9\u03b1 \u03b1\u03c0\u03cc\u03c0\u03c4\u03c9\u03c3\u03b7.<\/span><\/p>\n<h2><span style=\"font-weight: 400;\">FOXO4-DRI \u03ba\u03b1\u03b9 \u0393\u03b7\u03c1\u03b1\u03c3\u03bc\u03ad\u03bd\u03b1 \u039a\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1: \u03a3\u03b5 \u03c4\u03b9 \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03b5\u03af\u03c4\u03b1\u03b9;<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">\u0397 \u03b3\u03ae\u03c1\u03b1\u03bd\u03c3\u03b7 \u03b5\u03af\u03bd\u03b1\u03b9 \u03bc\u03b9\u03b1 \u03ba\u03b1\u03c4\u03ac\u03c3\u03c4\u03b1\u03c3\u03b7 \u03ba\u03b1\u03c4\u03ac \u03c4\u03b7\u03bd \u03bf\u03c0\u03bf\u03af\u03b1 \u03ad\u03bd\u03b1 \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03bf \u03b2\u03c1\u03af\u03c3\u03ba\u03b5\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03bc\u03cc\u03bd\u03b9\u03bc\u03b7 \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03ae. \u03a4\u03bf \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03bf \u03b5\u03af\u03bd\u03b1\u03b9 \u03ad\u03c4\u03bf\u03b9\u03bc\u03bf \u03bd\u03b1 \u03c0\u03b5\u03b8\u03ac\u03bd\u03b5\u03b9 \u03b1\u03bb\u03bb\u03ac \u03b1\u03bd\u03c4\u03b9\u03c3\u03c4\u03ad\u03ba\u03b5\u03c4\u03b1\u03b9 \u2013 \u03c0\u03b1\u03c1\u03b1\u03bc\u03ad\u03bd\u03bf\u03bd\u03c4\u03b1\u03c2 \u03bc\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03b9\u03ba\u03ac \u03b5\u03bd\u03b5\u03c1\u03b3\u03cc \u03ba\u03b1\u03b9 \u03b5\u03ba\u03ba\u03c1\u03b9\u03bd\u03ce\u03bd\u03c4\u03b1\u03c2 \u03b5\u03c0\u03af\u03c3\u03b7\u03c2. \u0391\u03c5\u03c4\u03ac \u03c4\u03b1 \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03b1\u03bd\u03b1\u03c0\u03c4\u03cd\u03c3\u03c3\u03bf\u03c5\u03bd \u03ad\u03bd\u03b1\u03bd \u03b5\u03ba\u03ba\u03c1\u03b9\u03c4\u03b9\u03ba\u03cc \u03c6\u03b1\u03b9\u03bd\u03cc\u03c4\u03c5\u03c0\u03bf \u03c3\u03c7\u03b5\u03c4\u03b9\u03b6\u03cc\u03bc\u03b5\u03bd\u03bf \u03bc\u03b5 \u03c4\u03b7 \u03b3\u03ae\u03c1\u03b1\u03bd\u03c3\u03b7, \u03ad\u03bd\u03b1\u03bd \u03b5\u03bc\u03bc\u03ad\u03bd\u03bf\u03bd\u03c4\u03b1 \u03c0\u03c1\u03bf\u03c6\u03bb\u03b5\u03b3\u03bc\u03bf\u03bd\u03ce\u03b4\u03b7 \u03c6\u03b1\u03b9\u03bd\u03cc\u03c4\u03c5\u03c0\u03bf \u03c0\u03bf\u03c5 \u03b5\u03bd\u03b4\u03ad\u03c7\u03b5\u03c4\u03b1\u03b9 \u03bd\u03b1 \u03c3\u03c5\u03bc\u03b2\u03ac\u03bb\u03bb\u03b5\u03b9 \u03c3\u03c4\u03b7\u03bd \u03b5\u03c0\u03b9\u03c4\u03b1\u03c7\u03c5\u03bd\u03cc\u03bc\u03b5\u03bd\u03b7 \u03b3\u03ae\u03c1\u03b1\u03bd\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03c4\u03b7 \u03c7\u03b7\u03bc\u03b5\u03b9\u03bf\u03c4\u03bf\u03be\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u0395\u03c1\u03b3\u03b1\u03c3\u03af\u03b5\u03c2 \u03b1\u03c0\u03cc \u03c4\u03bf 2011 \u03ba\u03b1\u03b9 \u03bc\u03b5\u03c4\u03ac \u03ad\u03b4\u03b5\u03b9\u03be\u03b1\u03bd \u03cc\u03c4\u03b9 \u03b7 \u03b1\u03c0\u03bf\u03bc\u03ac\u03ba\u03c1\u03c5\u03bd\u03c3\u03b7 \u03c4\u03c9\u03bd \u03b3\u03b5\u03c1\u03b1\u03c3\u03bc\u03ad\u03bd\u03c9\u03bd \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b1\u03c0\u03bf\u03c4\u03c1\u03ad\u03c8\u03b5\u03b9 \u03ae \u03bd\u03b1 \u03ba\u03b1\u03b8\u03c5\u03c3\u03c4\u03b5\u03c1\u03ae\u03c3\u03b5\u03b9 \u03c4\u03b7 \u03b4\u03c5\u03c3\u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1 \u03c4\u03c9\u03bd \u03b9\u03c3\u03c4\u03ce\u03bd, \u03ba\u03b1\u03b9 \u03cc\u03c4\u03b9 \u03c4\u03b1 \u03b3\u03b5\u03c1\u03b1\u03c3\u03bc\u03ad\u03bd\u03b1 \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03ba\u03b1\u03c4\u03b1\u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03bf\u03c5\u03bd \u03c4\u03b7 \u03b8\u03ad\u03c3\u03b7 \u03c4\u03c9\u03bd \u03c5\u03b3\u03b9\u03ce\u03bd \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd, \u03b5\u03c0\u03b7\u03c1\u03b5\u03ac\u03b6\u03bf\u03bd\u03c4\u03b1\u03c2 \u03b1\u03c1\u03bd\u03b7\u03c4\u03b9\u03ba\u03ac \u03c4\u03b7\u03bd \u03c4\u03bf\u03c0\u03b9\u03ba\u03ae \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1 \u03b5\u03ac\u03bd \u03b4\u03b5\u03bd \u03b1\u03c0\u03bf\u03bc\u03b1\u03ba\u03c1\u03c5\u03bd\u03b8\u03bf\u03cd\u03bd. \u0393\u03b9\u03b1\u03c4\u03af \u03bb\u03bf\u03b9\u03c0\u03cc\u03bd \u03c3\u03c5\u03bc\u03b2\u03b1\u03af\u03bd\u03b5\u03b9 \u03b1\u03c5\u03c4\u03cc \u03b1\u03c1\u03c7\u03b9\u03ba\u03ac; \u039b\u03bf\u03b9\u03c0\u03cc\u03bd, \u03b7 \u03b3\u03ae\u03c1\u03b1\u03bd\u03c3\u03b7 \u03c4\u03c9\u03bd \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03b4\u03b5\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03b5\u03be\u03af\u03c3\u03bf\u03c5 \u03ba\u03b1\u03ba\u03ae. \u0397 \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03ae \u03b3\u03ae\u03c1\u03b1\u03bd\u03c3\u03b7 \u03ad\u03c7\u03b5\u03b9 \u03b4\u03b9\u03c0\u03bb\u03ae \u03c6\u03cd\u03c3\u03b7 \u2013 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c3\u03c4\u03b7\u03bd \u03c0\u03c1\u03b1\u03b3\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1 \u03b5\u03c5\u03b5\u03c1\u03b3\u03b5\u03c4\u03b9\u03ba\u03ae \u03ba\u03b1\u03c4\u03ac \u03c4\u03b7\u03bd \u03b5\u03bc\u03b2\u03c1\u03c5\u03ca\u03ba\u03ae \u03b1\u03bd\u03ac\u03c0\u03c4\u03c5\u03be\u03b7, \u03c4\u03b7\u03bd \u03b1\u03c0\u03bf\u03ba\u03b1\u03c4\u03ac\u03c3\u03c4\u03b1\u03c3\u03b7 \u03c4\u03c9\u03bd \u03b9\u03c3\u03c4\u03ce\u03bd \u03ba\u03b1\u03b9 \u03c4\u03b7\u03bd \u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03bf\u03bb\u03ae \u03cc\u03b3\u03ba\u03c9\u03bd. \u0391\u03bb\u03bb\u03ac \u03b5\u03af\u03bd\u03b1\u03b9 \u03b5\u03c0\u03b9\u03b2\u03bb\u03b1\u03b2\u03ae\u03c2 \u03c5\u03c0\u03cc \u03c3\u03c5\u03bd\u03b8\u03ae\u03ba\u03b5\u03c2 \u03c7\u03c1\u03cc\u03bd\u03b9\u03bf\u03c5 \u03c3\u03c4\u03c1\u03b5\u03c2, \u03b5\u03c0\u03af\u03bc\u03bf\u03bd\u03bf\u03c5 \u03c4\u03c1\u03b1\u03c5\u03bc\u03b1\u03c4\u03b9\u03c3\u03bc\u03bf\u03cd \u03c4\u03c9\u03bd \u03b9\u03c3\u03c4\u03ce\u03bd \u03ba\u03b1\u03b9 \u03bc\u03b5\u03b9\u03c9\u03bc\u03ad\u03bd\u03b7\u03c2 \u03b1\u03c0\u03bf\u03bc\u03ac\u03ba\u03c1\u03c5\u03bd\u03c3\u03b7\u03c2.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">\u0388\u03c1\u03b5\u03c5\u03bd\u03b1 \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u039a\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03ae \u0393\u03ae\u03c1\u03b1\u03bd\u03c3\u03b7<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">\u03a4\u03bf FOXO4-DRI \u03bc\u03b5\u03bb\u03b5\u03c4\u03ac\u03c4\u03b1\u03b9 \u03ba\u03c5\u03c1\u03af\u03c9\u03c2 \u03c9\u03c2 \u03c0\u03b5\u03b9\u03c1\u03b1\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc \u03c3\u03b5\u03bd\u03bf\u03bb\u03c5\u03c4\u03b9\u03ba\u03cc \u03c0\u03b5\u03c0\u03c4\u03af\u03b4\u03b9\u03bf, \u03b4\u03b9\u03b1\u03ba\u03c1\u03b9\u03c4\u03b9\u03ba\u03cc \u03b1\u03c0\u03cc \u03c4\u03b1 \u03bc\u03b9\u03ba\u03c1\u03bf\u03bc\u03bf\u03c1\u03b9\u03b1\u03ba\u03ac \u03c3\u03b5\u03bd\u03bf\u03bb\u03c5\u03c4\u03b9\u03ba\u03ac. \u03a4\u03bf \u03b1\u03c1\u03c7\u03b9\u03ba\u03cc \u03bc\u03bf\u03bd\u03c4\u03ad\u03bb\u03bf in-vitro \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b5 \u03b1\u03bd\u03b8\u03c1\u03ce\u03c0\u03b9\u03bd\u03bf\u03c5\u03c2 \u03b9\u03bd\u03bf\u03b2\u03bb\u03ac\u03c3\u03c4\u03b5\u03c2 IMR90 \u03c3\u03b5 \u03b3\u03ae\u03c1\u03b1\u03bd\u03c3\u03b7 \u03c0\u03bf\u03c5 \u03c0\u03c1\u03bf\u03ba\u03bb\u03ae\u03b8\u03b7\u03ba\u03b5 \u03b1\u03c0\u03cc \u03b9\u03bf\u03bd\u03af\u03b6\u03bf\u03c5\u03c3\u03b1 \u03b1\u03ba\u03c4\u03b9\u03bd\u03bf\u03b2\u03bf\u03bb\u03af\u03b1. \u03a4\u03bf \u03b2\u03b1\u03c3\u03b9\u03ba\u03cc \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1; \u0395\u03be\u03b1\u03b9\u03c1\u03b5\u03c4\u03b9\u03ba\u03ae \u03b5\u03ba\u03bb\u03b5\u03ba\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1. \u0395\u03c0\u03af\u03c3\u03b7\u03c2, \u03c0\u03bf\u03bb\u03bb\u03ad\u03c2 \u03bc\u03b5\u03c4\u03b1\u03b3\u03b5\u03bd\u03ad\u03c3\u03c4\u03b5\u03c1\u03b5\u03c2 \u03bf\u03bc\u03ac\u03b4\u03b5\u03c2 \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b1\u03bd \u03c4\u03bf \u03c0\u03b5\u03c0\u03c4\u03af\u03b4\u03b9\u03bf \u03c9\u03c2 \u03b1\u03bd\u03b9\u03c7\u03bd\u03b5\u03c5\u03c4\u03ae \u03c3\u03b5 \u03b4\u03b9\u03ac\u03c6\u03bf\u03c1\u03bf\u03c5\u03c2 \u03c4\u03cd\u03c0\u03bf\u03c5\u03c2 \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03c0\u03bf\u03c5 \u03ba\u03c5\u03bc\u03b1\u03af\u03bd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03b9\u03bd\u03bf\u03b2\u03bb\u03ac\u03c3\u03c4\u03b5\u03c2 IMR90 \u03ba\u03b1\u03b9 \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 Leydig TM3 \u03ad\u03c9\u03c2 \u03c7\u03bf\u03bd\u03b4\u03c1\u03bf\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1, \u03b5\u03bd\u03b4\u03bf\u03b8\u03b7\u03bb\u03b9\u03b1\u03ba\u03ac \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03ba\u03b1\u03b9 \u03c0\u03bd\u03b5\u03c5\u03bc\u03bf\u03bd\u03b9\u03ba\u03bf\u03cd\u03c2 \u03b9\u03bd\u03bf\u03b2\u03bb\u03ac\u03c3\u03c4\u03b5\u03c2.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">\u0388\u03c1\u03b5\u03c5\u03bd\u03b1 \u03b3\u03b9\u03b1 \u03c4\u03b7 \u03a3\u03c7\u03b5\u03c4\u03ba\u03cc\u03bc\u03b5\u03bd\u03b7 \u03bc\u03b5 \u03c4\u03b7\u03bd \u0397\u03bb\u03b9\u03ba\u03af\u03b1 \u039b\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">\u03a3\u03b5 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 \u03c3\u03b5 \u03b6\u03ce\u03b1 \u03c0\u03b1\u03c1\u03b1\u03c4\u03b7\u03c1\u03ae\u03b8\u03b7\u03ba\u03b5 \u03b2\u03b5\u03bb\u03c4\u03af\u03c9\u03c3\u03b7 \u03c3\u03c4\u03b7 \u03c3\u03c9\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03b4\u03c1\u03b1\u03c3\u03c4\u03b7\u03c1\u03b9\u03cc\u03c4\u03b7\u03c4\u03b1, \u03c3\u03c4\u03b7\u03bd \u03ba\u03b1\u03c4\u03ac\u03c3\u03c4\u03b1\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03c4\u03c1\u03b9\u03c7\u03ce\u03bc\u03b1\u03c4\u03bf\u03c2, \u03c3\u03c4\u03bf\u03c5\u03c2 \u03b4\u03b5\u03af\u03ba\u03c4\u03b5\u03c2 \u03c4\u03c9\u03bd \u03bd\u03b5\u03c6\u03c1\u03ce\u03bd \u03ba\u03b1\u03b9 \u03c3\u03c4\u03b7 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1 \u03c4\u03c9\u03bd \u03b9\u03c3\u03c4\u03ce\u03bd. \u03a3\u03c4\u03bf \u03b1\u03c1\u03c7\u03b9\u03ba\u03cc \u03b5\u03c1\u03b5\u03c5\u03bd\u03b7\u03c4\u03b9\u03ba\u03cc \u03ad\u03c1\u03b3\u03bf, \u03c5\u03c0\u03ac\u03c1\u03c7\u03bf\u03c5\u03bd \u03b4\u03cd\u03bf \u03b2\u03b1\u03c3\u03b9\u03ba\u03ac \u03bc\u03bf\u03bd\u03c4\u03ad\u03bb\u03b1: \u03ad\u03bd\u03b1 \u03c3\u03c4\u03ad\u03bb\u03b5\u03c7\u03bf\u03c2 \u03bc\u03b5 \u03c4\u03b1\u03c7\u03b5\u03af\u03b1 \u03b3\u03ae\u03c1\u03b1\u03bd\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03ad\u03bb\u03bb\u03b5\u03b9\u03c8\u03b7 \u03b5\u03c0\u03b9\u03b4\u03b9\u03cc\u03c1\u03b8\u03c9\u03c3\u03b7\u03c2 DNA, \u03ba\u03b1\u03b9 \u03c6\u03c5\u03c3\u03b9\u03ba\u03ac \u03b3\u03b7\u03c1\u03b1\u03c3\u03bc\u03ad\u03bd\u03b1 \u03c0\u03bf\u03bd\u03c4\u03af\u03ba\u03b9\u03b1. \u03a4\u03b1 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03ad\u03c3\u03bc\u03b1\u03c4\u03b1 \u03ae\u03c4\u03b1\u03bd \u03c3\u03c5\u03bd\u03b5\u03c0\u03ae \u03ba\u03b1\u03b9 \u03c3\u03c4\u03b1 \u03b4\u03cd\u03bf. \u0397 \u03b4\u03c1\u03b1\u03c3\u03c4\u03b7\u03c1\u03b9\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c3\u03c4\u03bf\u03bd \u03c4\u03c1\u03bf\u03c7\u03cc \u03c4\u03c1\u03b5\u03be\u03af\u03bc\u03b1\u03c4\u03bf\u03c2 \u03ba\u03b1\u03b9 \u03b7 \u03b2\u03b1\u03b8\u03bc\u03bf\u03bb\u03bf\u03b3\u03af\u03b1 \u03c4\u03bf\u03c5 \u03c4\u03c1\u03b9\u03c7\u03ce\u03bc\u03b1\u03c4\u03bf\u03c2 \u03b1\u03be\u03b9\u03bf\u03bb\u03bf\u03b3\u03ae\u03b8\u03b7\u03ba\u03b1\u03bd \u03c3\u03b5 \u03c0\u03bf\u03bd\u03c4\u03af\u03ba\u03b9\u03b1 \u03ac\u03b3\u03c1\u03b9\u03bf\u03c5 \u03c4\u03cd\u03c0\u03bf\u03c5 (wild-type) \u03ba\u03b1\u03b9 XpdTTD\/TTD \u03b7\u03bb\u03b9\u03ba\u03af\u03b1\u03c2 26 \u03b5\u03b2\u03b4\u03bf\u03bc\u03ac\u03b4\u03c9\u03bd, \u03bc\u03b5 \u03c4\u03b7\u03bd \u03b1\u03c0\u03cc\u03c3\u03c4\u03b1\u03c3\u03b7 \u03c4\u03c1\u03b5\u03be\u03af\u03bc\u03b1\u03c4\u03bf\u03c2 \u03bd\u03b1 \u03bc\u03b5\u03c4\u03c1\u03ac\u03c4\u03b1\u03b9 \u03c3\u03b5 km \u03b1\u03bd\u03ac \u03b7\u03bc\u03ad\u03c1\u03b1. \u0397 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7 \u03b1\u03bd\u03ad\u03c6\u03b5\u03c1\u03b5 \u03b5\u03c0\u03af\u03c3\u03b7\u03c2 \u03bc\u03b5\u03b9\u03c9\u03bc\u03ad\u03bd\u03b7 \u03b5\u03bc\u03c6\u03ac\u03bd\u03b9\u03c3\u03b7 \u03c3\u03c0\u03b5\u03b9\u03c1\u03b1\u03bc\u03b1\u03c4\u03bf\u03c3\u03ba\u03bb\u03ae\u03c1\u03c5\u03bd\u03c3\u03b7\u03c2 \u03c4\u03c9\u03bd \u03bd\u03b5\u03c6\u03c1\u03ce\u03bd \u03ba\u03b1\u03b9 \u03b2\u03b5\u03bb\u03c4\u03b9\u03c9\u03bc\u03ad\u03bd\u03b7 \u03b9\u03ba\u03b1\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1 \u03bd\u03b5\u03c6\u03c1\u03b9\u03ba\u03ae\u03c2 \u03b4\u03b9\u03ae\u03b8\u03b7\u03c3\u03b7\u03c2 \u03c3\u03c4\u03b1 \u03c0\u03bf\u03bd\u03c4\u03af\u03ba\u03b9\u03b1 \u03c4\u03b1\u03c7\u03b5\u03af\u03b1 \u03b3\u03ae\u03c1\u03b1\u03bd\u03c3\u03b7\u03c2.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">\u0388\u03c1\u03b5\u03c5\u03bd\u03b1 \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u0391\u03bd\u03b1\u03c0\u03b1\u03c1\u03b1\u03b3\u03c9\u03b3\u03b9\u03ba\u03ae \u0393\u03ae\u03c1\u03b1\u03bd\u03c3\u03b7<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">\u03a5\u03c0\u03ae\u03c1\u03be\u03b1\u03bd \u03b4\u03cd\u03bf \u03be\u03b5\u03c7\u03c9\u03c1\u03b9\u03c3\u03c4\u03ad\u03c2 \u03ba\u03b9\u03bd\u03b5\u03b6\u03b9\u03ba\u03ad\u03c2 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03af\u03b4\u03b9\u03b1 \u03b5\u03c1\u03b5\u03c5\u03bd\u03b7\u03c4\u03b9\u03ba\u03ae \u03bf\u03bc\u03ac\u03b4\u03b1. \u03a3\u03c4\u03b7\u03bd \u03c0\u03c1\u03ce\u03c4\u03b7 (Zhang et al. 2020), \u03bf\u03b9 \u03b2\u03b5\u03bb\u03c4\u03b9\u03c9\u03bc\u03ad\u03bd\u03bf\u03b9 \u03b4\u03b5\u03af\u03ba\u03c4\u03b5\u03c2 \u03ad\u03b4\u03b5\u03b9\u03be\u03b1\u03bd \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03b7 \u03c4\u03b5\u03c3\u03c4\u03bf\u03c3\u03c4\u03b5\u03c1\u03cc\u03bd\u03b7 \u03bf\u03c1\u03bf\u03cd, \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03b1 3\u03b2-HSD \u03ba\u03b1\u03b9 CYP11A1, \u03bc\u03b5\u03b9\u03c9\u03bc\u03ad\u03bd\u03b7 \u03b4\u03b9\u03ac\u03bc\u03b5\u03c3\u03b7 \u03b4\u03c1\u03b1\u03c3\u03c4\u03b7\u03c1\u03b9\u03cc\u03c4\u03b7\u03c4\u03b1 SA-\u03b2-gal, \u03c7\u03b1\u03bc\u03b7\u03bb\u03cc\u03c4\u03b5\u03c1\u03b1 p53, p21 \u03ba\u03b1\u03b9 p16, \u03ba\u03b1\u03b8\u03ce\u03c2 \u03ba\u03b1\u03b9 \u03bc\u03b5\u03b9\u03c9\u03bc\u03ad\u03bd\u03b1 IL-1\u03b2, IL-6 \u03ba\u03b1\u03b9 TGF-\u03b2. \u0397 \u03b4\u03b5\u03cd\u03c4\u03b5\u03c1\u03b7 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7 (Li et al. 2024) \u03b5\u03af\u03c7\u03b5 \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03b5\u03c4\u03b9\u03ba\u03cc \u03c3\u03c7\u03b5\u03b4\u03b9\u03b1\u03c3\u03bc\u03cc \u03ba\u03b1\u03b9 \u03bc\u03b5\u03b3\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03b7 \u03b4\u03b9\u03ac\u03c1\u03ba\u03b5\u03b9\u03b1 \u03ad\u03ba\u03b8\u03b5\u03c3\u03b7\u03c2. \u03a4\u03bf \u03b1\u03bd\u03b1\u03c6\u03b5\u03c1\u03cc\u03bc\u03b5\u03bd\u03bf \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03ae\u03c4\u03b1\u03bd \u03b7 \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03b7 \u03c0\u03bf\u03b9\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c3\u03c0\u03ad\u03c1\u03bc\u03b1\u03c4\u03bf\u03c2 \u03ba\u03b1\u03b9 \u03b7 \u03b2\u03b5\u03bb\u03c4\u03b9\u03c9\u03bc\u03ad\u03bd\u03b7 \u03c3\u03c0\u03b5\u03c1\u03bc\u03b1\u03c4\u03bf\u03b3\u03ad\u03bd\u03b5\u03c3\u03b7 \u03c3\u03b5 \u03b7\u03bb\u03b9\u03ba\u03b9\u03c9\u03bc\u03ad\u03bd\u03b1 \u03c0\u03bf\u03bd\u03c4\u03af\u03ba\u03b9\u03b1 \u03c0\u03bf\u03c5 \u03ad\u03bb\u03b1\u03b2\u03b1\u03bd \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1, \u03bc\u03b5 \u03c4\u03bf\u03bd \u03c0\u03c1\u03bf\u03c4\u03b5\u03b9\u03bd\u03cc\u03bc\u03b5\u03bd\u03bf \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03cc \u03bd\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b7 \u03bc\u03b5\u03b9\u03c9\u03bc\u03ad\u03bd\u03b7 \u03ad\u03ba\u03ba\u03c1\u03b9\u03c3\u03b7 SASP \u03b1\u03c0\u03cc \u03c4\u03b1 \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 Leydig.\u00a0<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">\u038a\u03bd\u03b5\u03c2 \u03ba\u03b1\u03b9 \u0399\u03c3\u03c4\u03b9\u03ba\u03ae \u0388\u03c1\u03b5\u03c5\u03bd\u03b1<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">\u039f\u03b9 \u03b5\u03c1\u03b5\u03c5\u03bd\u03b7\u03c4\u03ad\u03c2 \u03ad\u03c7\u03bf\u03c5\u03bd \u03b5\u03c0\u03af\u03c3\u03b7\u03c2 \u03b5\u03be\u03b5\u03c4\u03ac\u03c3\u03b5\u03b9 \u03c4\u03bf FOXO4-DRI \u03c3\u03b5 \u03c0\u03b5\u03b9\u03c1\u03b1\u03bc\u03b1\u03c4\u03b9\u03ba\u03ac \u03bc\u03bf\u03bd\u03c4\u03ad\u03bb\u03b1 \u03c0\u03bd\u03b5\u03c5\u03bc\u03bf\u03bd\u03b9\u03ba\u03ae\u03c2 \u03af\u03bd\u03c9\u03c3\u03b7\u03c2, \u03c7\u03cc\u03bd\u03b4\u03c1\u03bf\u03c5 \u03ba\u03b1\u03b9 \u03b3\u03ae\u03c1\u03b1\u03bd\u03c3\u03b7\u03c2 \u03c4\u03c9\u03bd \u03b1\u03b3\u03b3\u03b5\u03af\u03c9\u03bd.<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>\u03a0\u03bd\u03b5\u03c5\u03bc\u03bf\u03bd\u03b9\u03ba\u03ae \u03af\u03bd\u03c9\u03c3\u03b7<\/b><span style=\"font-weight: 400;\">\u03a3\u03b5 \u03ad\u03bd\u03b1 \u03c0\u03bf\u03bd\u03c4\u03b9\u03ba\u03bf\u03cd \u03bc\u03bf\u03bd\u03c4\u03ad\u03bb\u03bf \u03c0\u03bd\u03b5\u03c5\u03bc\u03bf\u03bd\u03b9\u03ba\u03ae\u03c2 \u03af\u03bd\u03c9\u03c3\u03b7\u03c2 \u03c0\u03bf\u03c5 \u03c0\u03c1\u03bf\u03ba\u03bb\u03ae\u03b8\u03b7\u03ba\u03b5 \u03b1\u03c0\u03cc \u03b2\u03bb\u03b5\u03bf\u03bc\u03c5\u03ba\u03af\u03bd\u03b7, \u03c4\u03bf FOXO4-DRI \u03bc\u03b5\u03af\u03c9\u03c3\u03b5 \u03c4\u03b1 \u03b3\u03b7\u03c1\u03b1\u03c3\u03bc\u03ad\u03bd\u03b1 \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1, \u03bc\u03b5\u03af\u03c9\u03c3\u03b5 \u03c4\u03b7\u03bd \u03ad\u03ba\u03c6\u03c1\u03b1\u03c3\u03b7 \u03c4\u03bf\u03c5 SASP \u03ba\u03b1\u03b9 \u03b5\u03be\u03b1\u03c3\u03b8\u03ad\u03bd\u03b7\u03c3\u03b5 \u03c4\u03b9\u03c2 \u03bc\u03bf\u03c1\u03c6\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ad\u03c2 \u03b1\u03bb\u03bb\u03b1\u03b3\u03ad\u03c2 \u03ba\u03b1\u03b9 \u03c4\u03b7\u03bd \u03b5\u03bd\u03b1\u03c0\u03cc\u03b8\u03b5\u03c3\u03b7 \u03ba\u03bf\u03bb\u03bb\u03b1\u03b3\u03cc\u03bd\u03bf\u03c5 \u03c0\u03bf\u03c5 \u03c0\u03c1\u03bf\u03ba\u03bb\u03ae\u03b8\u03b7\u03ba\u03b1\u03bd \u03b1\u03c0\u03cc \u03c4\u03b7 \u03b2\u03bb\u03b5\u03bf\u03bc\u03c5\u03ba\u03af\u03bd\u03b7, \u03c3\u03c5\u03b3\u03ba\u03c1\u03af\u03c3\u03b9\u03bc\u03b1 \u03bc\u03b5 \u03c4\u03bf \u03b5\u03b3\u03ba\u03b5\u03ba\u03c1\u03b9\u03bc\u03ad\u03bd\u03bf \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03bf \u03c0\u03b9\u03c1\u03c6\u03b5\u043d\u0438\u03b4\u03cc\u03bd\u03b7\u00b7 \u03b5\u03c0\u03af\u03c3\u03b7\u03c2 \u03b1\u03cd\u03be\u03b7\u03c3\u03b5 \u03c4\u03bf \u03c0\u03bf\u03c3\u03bf\u03c3\u03c4\u03cc \u03c4\u03c9\u03bd \u03ba\u03c5\u03c8\u03b5\u03bb\u03b9\u03b4\u03b9\u03ba\u03ce\u03bd \u03b5\u03c0\u03b9\u03b8\u03b7\u03bb\u03b9\u03b1\u03ba\u03ce\u03bd \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03c4\u03cd\u03c0\u03bf\u03c5 2 \u03ba\u03b1\u03b9 \u03c4\u03c9\u03bd \u03b9\u03bd\u03bf\u03b2\u03bb\u03b1\u03c3\u03c4\u03ce\u03bd \u03b5\u03bd\u03ce \u03bc\u03b5\u03af\u03c9\u03c3\u03b5 \u03c4\u03bf\u03c5\u03c2 \u03bc\u03c5\u03bf\u03ca\u03bd\u03bf\u03b2\u03bb\u03ac\u03c3\u03c4\u03b5\u03c2, \u03ba\u03b1\u03b9 in vitro \u03ad\u03b4\u03b5\u03b9\u03be\u03b5 \u03c4\u03ac\u03c3\u03b7 \u03bd\u03b1 \u03b8\u03b1\u03bd\u03b1\u03c4\u03ce\u03bd\u03b5\u03b9 \u03bc\u03c5\u03bf\u03ca\u03bd\u03bf\u03b2\u03bb\u03ac\u03c3\u03c4\u03b5\u03c2 \u03c0\u03bf\u03c5 \u03c0\u03c1\u03bfinduc\u03ac\u03c1\u03bf\u03bd\u03c4\u03b1\u03bd \u03b1\u03c0\u03cc TGF-\u03b2<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>\u03a7\u03cc\u03bd\u03b4\u03c1\u03bf\u03c2<\/b><span style=\"font-weight: 400;\">\u03a4\u03b1 \u03b1\u03bd\u03b8\u03c1\u03cep\u03b9\u03bd\u03b1 \u03c7\u03bf\u03bd\u03b4\u03c1\u03bf\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03c0\u03bf\u03bb\u03bb\u03b1\u03c0\u03bb\u03b1\u03c3\u03b9\u03ac\u03c3\u03c4\u03b7\u03ba\u03b1\u03bd \u03ad\u03c9\u03c2 \u03c4\u03bf \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03bf \u03b4\u03b9\u03c0\u03bb\u03b1\u03c3\u03b9\u03b1\u03c3\u03bc\u03bf\u03cd \u03c0\u03bb\u03b7\u03b8\u03c5\u03c3\u03bc\u03bf\u03cd 9 \u03b3\u03b9\u03b1 \u03bd\u03b1 \u03c0\u03c1\u03bf\u03c3\u03bf\u03bc\u03bf\u03b9\u03ce\u03c3\u03bf\u03c5\u03bd \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03ad\u03c4\u03bf\u03b9\u03bc\u03b1 \u03b3\u03b9\u03b1 \u03b1\u03c5\u03c4\u03cc\u03bb\u03bf\u03b3\u03b7 \u03b5\u03bc\u03c6\u03cd\u03c4\u03b5\u03c5\u03c3\u03b7 \u03c7\u03bf\u03bd\u03b4\u03c1\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd, \u03bc\u03b5 PDL3 \u03c9\u03c2 \u03bc\u03ac\u03c1\u03c4\u03c5\u03c1\u03b1 \u03b5\u03bb\u03ac\u03c7\u03b9\u03c3\u03c4\u03bf\u03c5 \u03c0\u03bf\u03bb\u03bb\u03b1\u03c0\u03bb\u03b1\u03c3\u03b9\u03b1\u03c3\u03bc\u03bf\u03cd. \u03a4\u03bf FOXO4-DRI \u03b1\u03c0\u03bf\u03bc\u03ac\u03ba\u03c1\u03c5\u03bd\u03b5 \u03c0\u03b5\u03c1\u03b9\u03c3\u03c3\u03cc\u03c4\u03b5\u03c1\u03b1 \u03b1\u03c0\u03cc \u03c4\u03b1 \u03bc\u03b9\u03c3\u03ac \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 PDL9 \u03c7\u03c9\u03c1\u03af\u03c2 \u03bd\u03b1 \u03b5\u03c0\u03b7\u03c1\u03b5\u03ac\u03c3\u03b5\u03b9 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ac \u03c4\u03bf\u03bd \u03b1\u03c1\u03b9\u03b8\u03bc\u03cc \u03c4\u03c9\u03bd \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd PDL3 \u03ba\u03b1\u03b9 \u03bc\u03b5\u03af\u03c9\u03c3\u03b5 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ac \u03c4\u03bf \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03bf \u03b3\u03ae\u03c1\u03b1\u03bd\u03c3\u03b7\u03c2 \u03c3\u03c4\u03bf PDL9. \u0397 \u03c0\u03c1\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03b4\u03b5\u03bd \u03b5\u03bd\u03af\u03c3\u03c7\u03c5\u03c3\u03b5 \u03c4\u03b7 \u03c7\u03bf\u03bd\u03b4\u03c1\u03bf\u03b3\u03bf\u03bd\u03bf\u03b3\u03cc\u03bd\u03bf \u03b9\u03ba\u03b1\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c4\u03c9\u03bd \u03c7\u03bf\u03bd\u03b4\u03c1\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd PDL9, \u03b1\u03bd \u03ba\u03b1\u03b9 \u03bf \u03c7\u03cc\u03bd\u03b4\u03c1\u03bf\u03c2 \u03c0\u03bf\u03c5 \u03c0\u03b1\u03c1\u03ae\u03c7\u03b8\u03b7 \u03b1\u03c0\u03cc \u03c4\u03b1 \u03c0\u03c1\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03bc\u03ad\u03bd\u03b1 \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03ad\u03b4\u03b5\u03b9\u03be\u03b5 \u03c7\u03b1\u03bc\u03b7\u03bb\u03cc\u03c4\u03b5\u03c1\u03b7 \u03ad\u03ba\u03c6\u03c1\u03b1\u03c3\u03b7 \u03b5\u03ba\u03ba\u03c1\u03b9\u03c4\u03b9\u03ba\u03ce\u03bd \u03c0\u03b1\u03c1\u03b1\u03b3\u03cc\u03bd\u03c4\u03c9\u03bd \u03c3\u03c7\u03b5\u03c4\u03b9\u03ba\u03ce\u03bd \u03bc\u03b5 \u03c4\u03b7 \u03b3\u03ae\u03c1\u03b1\u03bd\u03c3\u03b7.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>\u0391\u03b3\u03b3\u03b5\u03b9\u03b1\u03ba\u03ae \u03b3\u03ae\u03c1\u03b1\u03bd\u03c3\u03b7<\/b><span style=\"font-weight: 400;\">\u0391\u03c5\u03c4\u03cc \u03b5\u03af\u03bd\u03b1\u03b9 \u03c4\u03bf \u03bd\u03b5\u03cc\u03c4\u03b5\u03c1\u03bf \u03ad\u03c1\u03b3\u03bf. \u039c\u03b5\u03bb\u03ad\u03c4\u03b7 \u03c4\u03bf\u03c5 2026 \u03b1\u03bd\u03b1\u03c6\u03ad\u03c1\u03b5\u03b9 \u03cc\u03c4\u03b9 \u03c4\u03bf FOXO4-DRI \u03c0\u03c1\u03bf\u03ba\u03b1\u03bb\u03b5\u03af \u03b1\u03c0\u03cc\u03c0\u03c4\u03c9\u03c3\u03b7 \u03c3\u03b5 \u03b3\u03b5\u03c1\u03b1\u03c3\u03bc\u03ad\u03bd\u03b1 \u03b5\u03bd\u03b4\u03bf\u03b8\u03b7\u03bb\u03b9\u03b1\u03ba\u03ac \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03b9\u03ce\u03bd\u03c4\u03b1\u03c2 \u03c4\u03b7\u03bd \u03bf\u03b4\u03cc p53\/BCL-2\/Caspase-3 \u03ba\u03b1\u03b9 \u03b2\u03b5\u03bb\u03c4\u03b9\u03ce\u03bd\u03b5\u03b9 \u03c4\u03b7\u03bd \u03b1\u03b3\u03b3\u03b5\u03b9\u03b1\u03ba\u03ae \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1, \u03b5\u03bd\u03ce \u03ba\u03b1\u03b8\u03c5\u03c3\u03c4\u03b5\u03c1\u03b5\u03af \u03c4\u03b7\u03bd \u03b1\u03b3\u03b3\u03b5\u03b9\u03b1\u03ba\u03ae \u03b3\u03ae\u03c1\u03b1\u03bd\u03c3\u03b7<\/span><\/li>\n<\/ul>\n<h2><span style=\"font-weight: 400;\">FOXO4-DRI \u03ad\u03bd\u03b1\u03bd\u03c4\u03b9 \u03ac\u03bb\u03bb\u03c9\u03bd \u03c3\u03b5\u03bd\u03bf\u03bb\u03c5\u03c4\u03b9\u03ba\u03ce\u03bd<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">\u0394\u03b5\u03bd \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03ac\u03bc\u03b5\u03c3\u03b7 \u201c\u03b5\u03bd\u03b1\u03bb\u03bb\u03b1\u03ba\u03c4\u03b9\u03ba\u03ae \u03bb\u03cd\u03c3\u03b7\u201d, \u03b1\u03bb\u03bb\u03ac \u03b4\u03b9\u03ac\u03c6\u03bf\u03c1\u03bf\u03b9 \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03bf\u03af \u03c3\u03c4\u03bf\u03c7\u03b5\u03cd\u03bf\u03c5\u03bd \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03b5\u03c4\u03b9\u03ba\u03ad\u03c2 \u03b1\u03bd\u03c4\u03b9\u03b1\u03c0\u03bf\u03c0\u03c4\u03c9\u03c4\u03b9\u03ba\u03ad\u03c2 \u03bf\u03b4\u03bf\u03cd\u03c2 \u03c4\u03c9\u03bd \u03b3\u03b7\u03c1\u03b1\u03c3\u03bc\u03ad\u03bd\u03c9\u03bd \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd, \u03bf\u03b9 \u03bf\u03c0\u03bf\u03af\u03b5\u03c2 \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03bd \u03bd\u03b1 \u03c3\u03c5\u03b3\u03ba\u03c1\u03b9\u03b8\u03bf\u03cd\u03bd \u03b1\u03b4\u03c1\u03ac. \u0395\u03c0\u03af\u03c3\u03b7\u03c2, \u03ad\u03c7\u03b5\u03c4\u03b5 \u03c5\u03c0\u03cc\u03c8\u03b7 \u03cc\u03c4\u03b9 \u03bf\u03b9 \u03b4\u03b9\u03ac\u03c6\u03bf\u03c1\u03bf\u03b9 \u03c4\u03cd\u03c0\u03bf\u03b9 \u03b3\u03b7\u03c1\u03b1\u03c3\u03bc\u03ad\u03bd\u03c9\u03bd \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03b1\u03bd\u03c4\u03b1\u03c0\u03bf\u03ba\u03c1\u03af\u03bd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03b5\u03c4\u03b9\u03ba\u03bf\u03cd\u03c2 \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b5\u03c2. \u03a9\u03c2 \u03b5\u03ba \u03c4\u03bf\u03cd\u03c4\u03bf\u03c5, \u03b4\u03b5\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03b5\u03bd\u03b1\u03bb\u03bb\u03b1\u03ba\u03c4\u03ad\u03c2 \u03bc\u03b5\u03c4\u03b1\u03be\u03cd \u03c4\u03bf\u03c5\u03c2. \u039a\u03b1\u03bd\u03ad\u03bd\u03b1\u03c2 \u03b1\u03c0\u03cc \u03b1\u03c5\u03c4\u03bf\u03cd\u03c2 \u03b4\u03b5\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03b5\u03ba \u03c6\u03cd\u03c3\u03b5\u03c9\u03c2 \u03b1\u03bd\u03ce\u03c4\u03b5\u03c1\u03bf\u03c2.<\/span><\/p>\n<table>\n<tbody>\n<tr>\n<td><\/td>\n<td><b>FOXO4-DRI<\/b><\/td>\n<td><b>Dasatinib + \u039a\u03bf\u03c5\u03b5\u03c1\u03c3\u03b5\u03c4\u03af\u03bd\u03b7<\/b><\/td>\n<td><b>\u03a6\u03b9\u03c3\u03b5\u03c4\u03af\u03bd\u03b7<\/b><\/td>\n<\/tr>\n<tr>\n<td><b>\u03a4\u03ac\u03be\u03b7<\/b><\/td>\n<td><span style=\"font-weight: 400;\">\u03a3\u03c5\u03bd\u03b8\u03b5\u03c4\u03b9\u03ba\u03cc D-\u03c1\u03b5\u03c4\u03c1\u03bf-\u03b1\u03bd\u03c3\u03c4\u03c1\u03bf\u03c6\u03b9\u03ba\u03cc \u03c0\u03b5\u03c0\u03c4\u03af\u03b4\u03b9\u03bf<\/span><\/td>\n<td><span style=\"font-weight: 400;\">\u0391\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03ad\u03b1\u03c2 \u03ba\u03b9\u03bd\u03ac\u03c3\u03b7\u03c2 \u03c3\u03c5\u03bd \u03c6\u03bb\u03b1\u03b2\u03bf\u03bd\u03bf\u03b5\u03b9\u03b4\u03ad\u03c2, \u03b1\u03c0\u03cc \u03c4\u03bf \u03c3\u03c4\u03cc\u03bc\u03b1<\/span><\/td>\n<td><span style=\"font-weight: 400;\">\u03a6\u03bb\u03b1\u03b2\u03bf\u03bd\u03bf\u03b5\u03b9\u03b4\u03ad\u03c2, \u03b1\u03c0\u03cc \u03c4\u03bf \u03c3\u03c4\u03cc\u03bc\u03b1<\/span><\/td>\n<\/tr>\n<tr>\n<td><b>\u039c\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03cc\u03c2<\/b><\/td>\n<td><span style=\"font-weight: 400;\">\u0394\u03b9\u03b1\u03c4\u03b1\u03c1\u03ac\u03c3\u03c3\u03b5\u03b9 \u03bc\u03af\u03b1 \u03c3\u03c5\u03b3\u03ba\u03b5\u03ba\u03c1\u03b9\u03bc\u03ad\u03bd\u03b7 \u03b1\u03bb\u03bb\u03b7\u03bb\u03b5\u03c0\u03af\u03b4\u03c1\u03b1\u03c3\u03b7 \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7\u03c2-\u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7\u03c2 (FOXO4-p53)<\/span><\/td>\n<td><span style=\"font-weight: 400;\">\u03a0\u03b1\u03c1\u03bf\u03b4\u03b9\u03ba\u03ac \u03b1\u03c0\u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03b9\u03b5\u03af \u03c4\u03b1 \u03b4\u03af\u03ba\u03c4\u03c5\u03b1 \u03b5\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7\u03c2 \u03c0\u03bf\u03c5 \u03c0\u03c1\u03bf\u03c3\u03c4\u03b1\u03c4\u03b5\u03cd\u03bf\u03c5\u03bd \u03c4\u03b1 \u03b3\u03b7\u03c1\u03b1\u03c3\u03bc\u03ad\u03bd\u03b1 \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1<\/span><\/td>\n<td><span style=\"font-weight: 400;\">\u0395\u03c5\u03c1\u03b5\u03af\u03b1 \u03c6\u03bb\u03b1\u03b2\u03bf\u03bd\u03bf\u03b5\u03b9\u03b4\u03ae\u03c2 \u03c3\u03b5\u03bd\u03bf\u03bb\u03c5\u03c4\u03b9\u03ba\u03ae \u03b4\u03c1\u03ac\u03c3\u03b7<\/span><\/td>\n<\/tr>\n<tr>\n<td><b>\u03a0\u03b1\u03c1\u03ac\u03b4\u03bf\u03c3\u03b7<\/b><\/td>\n<td><span style=\"font-weight: 400;\">\u0395\u03bd\u03b5\u03c3\u03b9\u03bc\u03cc \u03c3\u03b5 \u03b6\u03c9\u03b9\u03ba\u03ad\u03c2 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2<\/span><\/td>\n<td><span style=\"font-weight: 400;\">\u03a0\u03c1\u03bf\u03c6\u03bf\u03c1\u03b9\u03ba\u03cc<\/span><\/td>\n<td><span style=\"font-weight: 400;\">\u03a0\u03c1\u03bf\u03c6\u03bf\u03c1\u03b9\u03ba\u03cc<\/span><\/td>\n<\/tr>\n<tr>\n<td><b>\u0391\u03bd\u03b8\u03c1\u03ceip\u03b9\u03bd\u03b1 \u0394\u03b5\u03b4\u03bf\u03bc\u03ad\u03bd\u03b1<\/b><\/td>\n<td><span style=\"font-weight: 400;\">\u039a\u03b1\u03bd\u03ad\u03bd\u03b1<\/span><\/td>\n<td><span style=\"font-weight: 400;\">\u03a0\u03b9\u03bb\u03bf\u03c4\u03b9\u03ba\u03ad\u03c2 \u03b4\u03bf\u03ba\u03b9\u03bc\u03ad\u03c2 \u03c0\u03c1\u03ce\u03b9\u03bc\u03b7\u03c2 \u03c6\u03ac\u03c3\u03b7\u03c2<\/span><\/td>\n<td><span style=\"font-weight: 400;\">\u039f\u03b9 \u03b4\u03bf\u03ba\u03b9\u03bc\u03ad\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c3\u03b5 \u03b5\u03be\u03ad\u03bb\u03b9\u03be\u03b7<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>&nbsp;<\/p>\n<h2><span style=\"font-weight: 400;\">\u03a0\u03c1\u03c9\u03c4\u03cc\u03ba\u03bf\u03bb\u03bb\u03b1 \u03b4\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03af\u03b1\u03c2 FOXO4-DRI \u03c3\u03c4\u03b7\u03bd \u03ad\u03c1\u03b5\u03c5\u03bd\u03b1 \u03ad\u03bd\u03b1\u03bd\u03c4\u03b9 \u03c4\u03bf\u03c5 biohacking \u03ba\u03b1\u03b9 \u03c4\u03c9\u03bd \u03b1\u03bd\u03b1\u03c6\u03bf\u03c1\u03ce\u03bd \u03c4\u03bf\u03c5 Reddit<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">\u039f\u03b9 \u03c0\u03b1\u03c1\u03b1\u03ba\u03ac\u03c4\u03c9 \u03b1\u03c1\u03b9\u03b8\u03bc\u03bf\u03af \u03b5\u03af\u03bd\u03b1\u03b9 \u03c0\u03b1\u03c1\u03ac\u03bc\u03b5\u03c4\u03c1\u03bf\u03b9 \u03b6\u03ce\u03c9\u03bd \u03ba\u03b1\u03b9 \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03bf\u03ba\u03b1\u03bb\u03bb\u03b9\u03ad\u03c1\u03b3\u03b5\u03b9\u03b1\u03c2 \u03c0\u03bf\u03c5 \u03ba\u03b1\u03c4\u03b1\u03b3\u03c1\u03ac\u03c6\u03b7\u03ba\u03b1\u03bd \u03b3\u03b9\u03b1 \u03b1\u03bd\u03b1\u03c0\u03b1\u03c1\u03b1\u03b3\u03c9\u03b3\u03b9\u03bc\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c3\u03b5 \u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03b7\u03c1\u03b9\u03b1\u03ba\u03cc \u03c0\u03b5\u03c1\u03b9\u03b2\u03ac\u03bb\u03bb\u03bf\u03bd. \u0394\u03b5\u03bd \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03ba\u03b1\u03b8\u03b9\u03b5\u03c1\u03c9\u03bc\u03ad\u03bd\u03b7 \u03b4\u03cc\u03c3\u03b7 \u03b3\u03b9\u03b1 \u03c4\u03bf\u03bd \u03ac\u03bd\u03b8\u03c1\u03c9\u03c0\u03bf, \u03b4\u03b5\u03bd \u03c5\u03c0\u03ac\u03c1\u03c7\u03bf\u03c5\u03bd \u03b4\u03b5\u03b4\u03bf\u03bc\u03ad\u03bd\u03b1 \u03b1\u03c3\u03c6\u03ac\u03bb\u03b5\u03b9\u03b1\u03c2 \u03b3\u03b9\u03b1 \u03c4\u03bf\u03bd \u03ac\u03bd\u03b8\u03c1\u03c9\u03c0\u03bf, \u03b4\u03b5\u03bd \u03c5\u03c0\u03ac\u03c1\u03c7\u03bf\u03c5\u03bd \u03b4\u03b5\u03b4\u03bf\u03bc\u03ad\u03bd\u03b1 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2 \u03b3\u03b9\u03b1 \u03c4\u03bf\u03bd \u03ac\u03bd\u03b8\u03c1\u03c9\u03c0\u03bf, \u03ba\u03b1\u03b9 \u03b4\u03b5\u03bd \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03b5\u03c0\u03b9\u03ba\u03c5\u03c1\u03c9\u03bc\u03ad\u03bd\u03bf\u03c2 \u03c4\u03c1\u03cc\u03c0\u03bf\u03c2 \u03bc\u03b5\u03c4\u03b1\u03c4\u03c1\u03bf\u03c0\u03ae\u03c2 \u03bc\u03b9\u03b1\u03c2 \u03c4\u03b9\u03bc\u03ae\u03c2 mg\/kg \u03b1\u03c0\u03cc \u03b6\u03ce\u03b1 \u03c3\u03b5 \u03b1\u03bd\u03b8\u03c1\u03ce\u03c0\u03b9\u03bd\u03b7 \u03c4\u03b9\u03bc\u03ae.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">\u0394\u03b7\u03bc\u03bf\u03c3\u03b9\u03b5\u03c5\u03bc\u03ad\u03bd\u03b1 \u0395\u03c1\u03b5\u03c5\u03bd\u03b7\u03c4\u03b9\u03ba\u03ac \u03a0\u03c1\u03c9\u03c4\u03cc\u03ba\u03bf\u03bb\u03bb\u03b1<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">\u0397 \u03b4\u03b9\u03b1\u03ba\u03bf\u03c0\u03c4\u03cc\u03bc\u03b5\u03bd\u03b7 \u03c7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03b7 \u03c3\u03cd\u03bd\u03c4\u03bf\u03bc\u03b7\u03c2 \u03b4\u03b9\u03ac\u03c1\u03ba\u03b5\u03b9\u03b1\u03c2 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03af \u03c4\u03bf\u03bd \u03ba\u03b1\u03bd\u03cc\u03bd\u03b1\u03c2 \u03c3\u03c4\u03b7 \u03b2\u03b9\u03b2\u03bb\u03b9\u03bf\u03b3\u03c1\u03b1\u03c6\u03af\u03b1, \u03ba\u03b1\u03b9 \u03ba\u03b1\u03bc\u03af\u03b1 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7 \u03b4\u03cc\u03c3\u03b7\u03c2-\u03b1\u03c0\u03cc\u03ba\u03c1\u03b9\u03c3\u03b7\u03c2 \u03ae \u03b2\u03b5\u03bb\u03c4\u03b9\u03c3\u03c4\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7\u03c2 \u03c4\u03b7\u03c2 \u03b4\u03cc\u03c3\u03b7\u03c2 \u03b4\u03b5\u03bd \u03ad\u03c7\u03b5\u03b9 \u03b4\u03b7\u03bc\u03bf\u03c3\u03b9\u03b5\u03c5\u03b8\u03b5\u03af \u03b3\u03b9\u03b1 \u03b1\u03c5\u03c4\u03cc \u03c4\u03bf \u03c0\u03b5\u03c0\u03c4\u03af\u03b4\u03b9\u03bf. \u0391\u03ba\u03bf\u03bb\u03bf\u03c5\u03b8\u03bf\u03cd\u03bd \u03bf\u03b9 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 \u03ba\u03b1\u03b9 \u03b7 \u03b4\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03af\u03b1 \u03c0\u03bf\u03c5 \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b1\u03bd:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Baar et al. 2027, Cell: \u0391\u03ba\u03c4\u03b9\u03bd\u03bf\u03b2\u03bf\u03bb\u03b7\u03bc\u03ad\u03bd\u03b1 \u03b9\u03bd\u03bf\u03b2\u03bb\u03ac\u03c3\u03c4\u03b1 IMR90 in vitro, \u03c0\u03bf\u03bd\u03c4\u03af\u03ba\u03b9\u03b1 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03bc\u03ad\u03bd\u03b1 \u03bc\u03b5 \u03b4\u03bf\u03be\u0648\u0631\u0648\u0628\u03b9\u03ba\u03af\u03bd\u03b7, \u03c0\u03bf\u03bd\u03c4\u03af\u03ba\u03b9\u03b1 \u03c4\u03b1\u03c7\u03b5\u03af\u03b1 \u03b3\u03ae\u03c1\u03b1\u03bd\u03c3\u03b7\u03c2 XpdTTD\/TTD, \u03c6\u03c5\u03c3\u03b9\u03ba\u03ac \u03b7\u03bb\u03b9\u03ba\u03b9\u03c9\u03bc\u03ad\u03bd\u03b1 \u03c0\u03bf\u03bd\u03c4\u03af\u03ba\u03b9\u03b1. 4 \u03ad\u03c9\u03c2 5 \u03ac\u03b3\u03c1\u03b9\u03bf\u03c5 \u03c4\u03cd\u03c0\u03bf\u03c5 \u03ae XpdTTD\/TTD \u03c0\u03bf\u03bd\u03c4\u03af\u03ba\u03b9\u03b1 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03bc\u03ad\u03bd\u03b1 \u03c4\u03b7\u03bd \u03b7\u03bc\u03ad\u03c1\u03b1 0, 2 \u03ba\u03b1\u03b9 4 \u03bc\u03b5 5 mg\/kg FOXO4-DRI \u03bc\u03b5 \u03b5\u03bd\u03b4\u03bf\u03c6\u03bb\u03ad\u03b2\u03b9\u03b1 \u03ad\u03bd\u03b5\u03c3\u03b7, \u03bc\u03b5 \u03b4\u03b5\u03af\u03b3\u03bc\u03b1 \u03b1\u03af\u03bc\u03b1\u03c4\u03bf\u03c2 \u03bd\u03b1 \u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03b5\u03c4\u03b1\u03b9 28 \u03b7\u03bc\u03ad\u03c1\u03b5\u03c2 \u03bc\u03b5\u03c4\u03ac \u03c4\u03b7\u03bd \u03c0\u03c1\u03ce\u03c4\u03b7 \u03ad\u03bd\u03b5\u03c3\u03b7, \u03ba\u03b1\u03b9 \u03b3\u03b9\u03b1 \u03c4\u03bf \u03c3\u03ba\u03ad\u03bb\u03bf\u03c2 \u03c7\u03b7\u03bc\u03b5\u03b9\u03bf\u03c4\u03bf\u03be\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2, \u03bc\u03af\u03b1 \u03bc\u03cc\u03bd\u03bf \u03b4\u03cc\u03c3\u03b7 \u03b4\u03bf\u03be\u0648\u0631\u0648\u0628\u03b9\u03ba\u03af\u03bd\u03b7\u03c2 \u03c3\u03c4\u03b1 10 mg\/kg i.p. \u03b1\u03ba\u03bf\u03bb\u03bf\u03c5\u03b8\u03bf\u03cd\u03bc\u03b5\u03bd\u03b7 \u03b1\u03c0\u03cc FOXO4-DRI \u03c3\u03b5 4 x 10 mg\/kg i.v., \u03c3\u03c5\u03bd \u03ad\u03bd\u03b1 \u03b4\u03b5\u03cd\u03c4\u03b5\u03c1\u03bf \u03c0\u03b5\u03af\u03c1\u03b1\u03bc\u03b1 \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03ce\u03bd\u03c4\u03b1\u03c2 \u03b4\u03cd\u03bf \u03b4\u03cc\u03c3\u03b5\u03b9\u03c2 \u03b4\u03bf\u03be\u0648\u0631\u0648\u0628\u03b9\u03ba\u03af\u03bd\u03b7\u03c2 \u03b1\u03ba\u03bf\u03bb\u03bf\u03c5\u03b8\u03bf\u03cd\u03bc\u03b5\u03bd\u03b5\u03c2 \u03b1\u03c0\u03cc FOXO4-DRI \u03c3\u03b5 3 x 5 mg\/kg \u03bc\u03b5 \u03bc\u03af\u03b1 \u03b7\u03bc\u03ad\u03c1\u03b1 \u03b5\u03bd\u03b4\u03b9\u03ac\u03bc\u03b5\u03c3\u03b1.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Zhang et al. 2020, Aging: \u03a6\u03c5\u03c3ically \u03b3\u03b5\u03c1\u03b1\u03c3\u03bc\u03ad\u03bd\u03b1 \u03c0\u03bf\u03bd\u03c4\u03af\u03ba\u03b9\u03b1 \u03b7\u03bb\u03b9\u03ba\u03af\u03b1\u03c2 20 \u03ad\u03c9\u03c2 24 \u03bc\u03b7\u03bd\u03ce\u03bd, 5 mg\/kg \u03c3\u03b5 PBS, \u03b5\u03bd\u03b4\u03bfperitoneal, \u03ba\u03ac\u03b8\u03b5 \u03b4\u03b5\u03cd\u03c4\u03b5\u03c1\u03b7 \u03b7\u03bc\u03ad\u03c1\u03b1, \u03c4\u03c1\u03b5\u03b9\u03c2 \u03c7\u03bf\u03c1\u03b7\u03b3\u03ae\u03c3\u03b5\u03b9\u03c2.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Huang et al. 2021, Front Bioeng Biotechnol.: In vitro \u03bc\u03cc\u03bd\u03bf, \u03b1\u03bd\u03b8\u03c1\u03cep\u03b9\u03bd\u03b1 \u03c7\u03bf\u03bd\u03b4\u03c1\u03bf\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03c3\u03b5 PDL9 \u03ad\u03bd\u03b1\u03bd\u03c4\u03b9 PDL3.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Han et al. 2022, J Cell Mol Med.: \u0391\u03c1\u03c3\u03b5\u03bd\u03b9\u03ba\u03ac \u03c0\u03bf\u03bd\u03c4\u03af\u03ba\u03b9\u03b1 C57BL\/6J, \u03b7\u03bb\u03b9\u03ba\u03af\u03b1\u03c2 6 \u03ad\u03c9\u03c2 8 \u03b5\u03b2\u03b4\u03bf\u03bc\u03ac\u03b4\u03c9\u03bd, \u03c0\u03b5\u03c0\u03c4\u03af\u03b4\u03b9\u03bf \u03b1\u03c1\u03b1\u03b9\u03c9\u03bc\u03ad\u03bd\u03bf \u03c3\u03b5 1 mg\/mL \u03c3\u03b5 PBS \u03c0\u03c1\u03b9\u03bd \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03b5\u03bd\u03b4\u03bfperitoneal \u03ad\u03bd\u03b5\u03c3\u03b7.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Li et al. 2024, Exp Gerontol.: 20\u03bc\u03b7\u03bd\u03b1 \u03c0\u03bf\u03bd\u03c4\u03af\u03ba\u03b9\u03b1, 5 mg\/kg\/\u03b7\u03bc\u03ad\u03c1\u03b1 \u03b5\u03bd\u03b4\u03bfperitoneally \u03b3\u03b9\u03b1 30 \u03b7\u03bc\u03ad\u03c1\u03b5\u03c2.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Hu et al. 2026, Front Bioeng Biotechnol.: 17 \u03bc\u03b7\u03bd\u03ce\u03bd \u03c0\u03bf\u03bd\u03c4\u03af\u03ba\u03b9\u03b1, 5 mg\/kg \u03b5\u03bd\u03b4\u03bfperitoneal \u03ba\u03ac\u03b8\u03b5 2 \u03b7\u03bc\u03ad\u03c1\u03b5\u03c2 \u03b3\u03b9\u03b1 1 \u03bc\u03ae\u03bd\u03b1.<\/span><\/li>\n<\/ul>\n<h3><span style=\"font-weight: 400;\">\u0392\u03b9\u03bfhacking \u03ba\u03b1\u03b9 \u03b1\u03bd\u03b1\u03c6\u03bf\u03c1\u03ad\u03c2 \u03c4\u03bf\u03c5 Reddit<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">\u03a5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03c3\u03af\u03b3\u03bf\u03c5\u03c1\u03b1 \u03ba\u03ac\u03c0\u03bf\u03b9\u03b1 \u03c3\u03c5\u03b6\u03ae\u03c4\u03b7\u03c3\u03b7 \u03b3\u03cd\u03c1\u03c9 \u03b1\u03c0\u03cc \u03b1\u03c5\u03c4\u03cc \u03c4\u03bf \u03c0\u03b5\u03c0\u03c4\u03af\u03b4\u03b9\u03bf, \u03b1\u03bb\u03bb\u03ac \u03ba\u03b1\u03bc\u03af\u03b1 \u03b1\u03c0\u03cc \u03c4\u03b9\u03c2 \u03c0\u03b1\u03c1\u03b1\u03ba\u03ac\u03c4\u03c9 \u03b4\u03b5\u03bd \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b1\u03bd\u03b1\u03c0\u03b1\u03c1\u03b1\u03c7\u03b8\u03b5\u03af \u03c9\u03c2 \u03c0\u03c1\u03c9\u03c4\u03cc\u03ba\u03bf\u03bb\u03bb\u03bf. \u03a5\u03c0\u03ac\u03c1\u03c7\u03bf\u03c5\u03bd \u03c0\u03bf\u03bb\u03bb\u03ad\u03c2 \u03b1\u03bd\u03b1\u03c6\u03bf\u03c1\u03ad\u03c2 \u03b1\u03c5\u03c4\u03bf\u03c0\u03b5\u03b9\u03c1\u03b1\u03bc\u03b1\u03c4\u03b9\u03c3\u03bc\u03bf\u03cd \u03c0\u03bf\u03c5 \u03ba\u03c5\u03ba\u03bb\u03bf\u03c6\u03bf\u03c1\u03bf\u03cd\u03bd \u03c3\u03b5 \u03c6\u03cc\u03c1\u03bf\u03c5\u03bc \u03ba\u03b1\u03b9 \u03b9\u03c3\u03c4\u03bf\u03bb\u03cc\u03b3\u03b9\u03b1 \u03c0\u03c1\u03bf\u03bc\u03b7\u03b8\u03b5\u03c5\u03c4\u03ce\u03bd, \u03ba\u03b1\u03b9 \u03b5\u03af\u03bd\u03b1\u03b9 \u03cc\u03bb\u03b5\u03c2 \u03b1\u03bd\u03b5\u03be\u03ad\u03bb\u03b5\u03b3\u03ba\u03c4\u03b5\u03c2 \u03ba\u03b1\u03b9 \u03b2\u03b1\u03c3\u03b9\u03c3\u03bc\u03ad\u03bd\u03b5\u03c2 \u03c3\u03b5 \u03b1\u03c5\u03c4\u03bf\u03b1\u03be\u03b9\u03bf\u03bb\u03cc\u03b3\u03b7\u03c3\u03b7. \u0394\u03b5\u03bd \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03ba\u03b1\u03bc\u03af\u03b1 \u03b1\u03bd\u03b5\u03be\u03ac\u03c1\u03c4\u03b7\u03c4\u03b7 \u03b5\u03c0\u03b1\u03bb\u03ae\u03b8\u03b5\u03c5\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03c4\u03b1\u03c5\u03c4\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2, \u03c4\u03b7\u03c2 \u03ba\u03b1\u03b8\u03b1\u03c1\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2 \u03ae \u03c4\u03bf\u03c5 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03ad\u03c3\u03bc\u03b1\u03c4\u03bf\u03c2 \u03c4\u03b7\u03c2 \u03ad\u03bd\u03c9\u03c3\u03b7\u03c2 \u03c3\u03b5 \u03ba\u03b1\u03bc\u03af\u03b1 \u03b1\u03c0\u03cc \u03b1\u03c5\u03c4\u03ad\u03c2.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u0395\u03c0\u03af\u03c3\u03b7\u03c2, \u03b1\u03c5\u03c4\u03ad\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03ba\u03bb\u03b9\u03bc\u03b1\u03ba\u03ce\u03c3\u03b5\u03b9\u03c2 \u03b2\u03ac\u03c3\u03b5\u03b9 \u03c3\u03c9\u03bc\u03b1\u03c4\u03b9\u03ba\u03bf\u03cd \u03b2\u03ac\u03c1\u03bf\u03c5\u03c2 \u03bc\u03b9\u03b1\u03c2 \u03b4\u03cc\u03c3\u03b7\u03c2 \u03c3\u03b5 \u03c0\u03bf\u03bd\u03c4\u03af\u03ba\u03bf\u03c5\u03c2 \u03c7\u03c9\u03c1\u03af\u03c2 \u03c3\u03c5\u03bd\u03c4\u03b5\u03bb\u03b5\u03c3\u03c4\u03ae \u03b4\u03b9\u03b1\u03b5\u03af\u03b4\u03bf\u03c5\u03c2 \u03ba\u03bb\u03b9\u03bc\u03ac\u03ba\u03c9\u03c3\u03b7\u03c2, \u03c7\u03c9\u03c1\u03af\u03c2 \u03b4\u03b5\u03b4\u03bf\u03bc\u03ad\u03bd\u03b1 \u03c6\u03b1\u03c1\u03bc\u03b1\u03ba\u03bf\u03ba\u03b9\u03bd\u03b7\u03c4\u03b9\u03ba\u03ae\u03c2 \u03ba\u03b1\u03b9 \u03c7\u03c9\u03c1\u03af\u03c2 \u03c4\u03bf\u03be\u03b9\u03ba\u03bf\u03bb\u03bf\u03b3\u03af\u03b1.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u0393\u03b5\u03bd\u03b9\u03ba\u03ac, \u03c0\u03bf\u03bb\u03bb\u03ad\u03c2 \u03c0\u03c1\u03bf\u03c3\u03c9\u03c0\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b5\u03c2 \u03c4\u03c9\u03bd \u03bc\u03ad\u03c3\u03c9\u03bd \u03ba\u03bf\u03b9\u03bd\u03c9\u03bd\u03b9\u03ba\u03ae\u03c2 \u03b4\u03b9\u03ba\u03c4\u03cd\u03c9\u03c3\u03b7\u03c2 \u03ba\u03b1\u03b9 \u03c5\u03c0\u03bf\u03b5\u03bd\u03cc\u03c4\u03b7\u03c4\u03b5\u03c2 (subreddits) \u03cc\u03c0\u03c9\u03c2 \u03c4\u03b1 r\/Biohack_Blueprint, r\/Peptides \u03ba.\u03bb\u03c0., \u03c0\u03c1\u03bf\u03c3\u03c6\u03ad\u03c1\u03bf\u03c5\u03bd \u03bc\u03b1\u03c1\u03c4\u03c5\u03c1\u03af\u03b5\u03c2 \u03c7\u03c1\u03b7\u03c3\u03c4\u03ce\u03bd \u03b3\u03b9\u03b1 \u03c4\u03bf \u03c4\u03b9 \u03b4\u03bf\u03ba\u03af\u03bc\u03b1\u03c3\u03b1\u03bd \u03bf\u03b9 \u03ac\u03bd\u03b8\u03c1\u03c9\u03c0\u03bf\u03b9. \u039a\u03b1\u03c4\u03cc\u03c0\u03b9\u03bd \u03bc\u03b9\u03b1\u03c2 \u03b5\u03bc\u03c0\u03b5\u03c1\u03b9\u03c3\u03c4\u03b1\u03c4\u03c9\u03bc\u03ad\u03bd\u03b7\u03c2 \u03b1\u03bd\u03b1\u03c3\u03ba\u03cc\u03c0\u03b7\u03c3\u03b7\u03c2, \u03b4\u03b5\u03bd \u03bc\u03c0\u03bf\u03c1\u03ad\u03c3\u03b1\u03bc\u03b5 \u03bd\u03b1 \u03b2\u03c1\u03bf\u03cd\u03bc\u03b5 \u03ba\u03b1\u03bc\u03af\u03b1 \u03c3\u03c4\u03b1\u03b8\u03b5\u03c1\u03ac \u03ba\u03b1\u03bb\u03ae \u03b4\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03af\u03b1. \u0397 \u03c0\u03c1\u03cc\u03ba\u03bb\u03b7\u03c3\u03b7 \u03b5\u03b4\u03ce \u03b5\u03af\u03bd\u03b1\u03b9 \u03c0\u03c1\u03b1\u03b3\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u2013 \u03bf\u03b9 \u03ac\u03bd\u03b8\u03c1\u03c9\u03c0\u03bf\u03b9 \u03b1\u03c0\u03bb\u03ce\u03c2 \u03b4\u03b5\u03bd \u03be\u03ad\u03c1\u03bf\u03c5\u03bd \u03c0\u03ce\u03c2 \u03bd\u03b1 \u03c0\u03b1\u03c1\u03b5\u03ba\u03c4\u03b5\u03af\u03bd\u03bf\u03c5\u03bd \u03c4\u03bf FOXO4-DRI. \u03a5\u03c0\u03ac\u03c1\u03c7\u03bf\u03c5\u03bd \u03bc\u03b5\u03bc\u03bf\u03bd\u03c9\u03bc\u03ad\u03bd\u03b1, \u03bb\u03b5\u03c0\u03c4\u03bf\u03bc\u03b5\u03c1\u03ae \u03b1\u03c5\u03c4\u03bf\u03c0\u03b5\u03b9\u03c1\u03ac\u03bc\u03b1\u03c4\u03b1, \u03b1\u03bb\u03bb\u03ac \u03c3\u03c5\u03c7\u03bd\u03ac \u03c3\u03c4\u03b5\u03c1\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03bf\u03c0\u03bf\u03b9\u03b1\u03c3\u03b4\u03ae\u03c0\u03bf\u03c4\u03b5 \u03ba\u03b1\u03c4\u03ac\u03bb\u03bb\u03b7\u03bb\u03b7\u03c2 \u03b1\u03bd\u03b1\u03c6\u03bf\u03c1\u03ac\u03c2. \u0388\u03bd\u03b1 \u03bc\u03b5\u03b3\u03ac\u03bb\u03bf \u03bc\u03ad\u03c1\u03bf\u03c2 \u03c4\u03b7\u03c2 \u03ba\u03bf\u03b9\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2 \u03c4\u03bf\u03c5 biohacking \u03b4\u03b9\u03c3\u03c4\u03ac\u03b6\u03b5\u03b9 \u03bd\u03b1 \u03ba\u03ac\u03bd\u03b5\u03b9 \u03bc\u03b9\u03b1 \u03c3\u03c5\u03b6\u03ae\u03c4\u03b7\u03c3\u03b7 \u03b3\u03b9\u03b1 \u03c4\u03b7 \u03b4\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03af\u03b1 \u03c4\u03bf\u03c5 FOXO4-DRI, \u03ba\u03b1\u03b9 \u03c0\u03bf\u03bb\u03bb\u03bf\u03af biohackers \u03b1\u03c0\u03bb\u03ce\u03c2 \u03b5\u03c0\u03b9\u03c3\u03c4\u03c1\u03ad\u03c6\u03bf\u03c5\u03bd \u03c3\u03b5 \u03ac\u03bb\u03bb\u03b1 \u03c0\u03b5\u03c0\u03c4\u03af\u03b4\u03b9\u03b1 \u03cc\u03c4\u03b1\u03bd \u03b1\u03c0\u03b1\u03bd\u03c4\u03bf\u03cd\u03bd \u03c3\u03c4\u03bf\u03bd \u03ba\u03b1\u03b8\u03bf\u03c1\u03b9\u03c3\u03bc\u03cc \u03b4\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03b9\u03ce\u03bd \u03ae \u03c3\u03c4\u03bf staking \u03c4\u03bf\u03c5 FOXO4-DRI.<\/span><\/p>\n<h2><span style=\"font-weight: 400;\">\u03a0\u03c1\u03bf\u03b5\u03c4\u03bf\u03b9\u03bc\u03b1\u03c3\u03af\u03b1 \u03ba\u03b1\u03b9 \u03b1\u03c0\u03bf\u03b8\u03ae\u03ba\u03b5\u03c5\u03c3\u03b7<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">\u03a4\u03ce\u03c1\u03b1, \u03b4\u03b5\u03af\u03c4\u03b5 \u03c0\u03ce\u03c2 \u03bd\u03b1 \u03c0\u03c1\u03bf\u03b5\u03c4\u03bf\u03b9\u03bc\u03ac\u03c3\u03b5\u03c4\u03b5 \u03ba\u03b1\u03b9 \u03bd\u03b1 \u03b1\u03c0\u03bf\u03b8\u03b7\u03ba\u03b5\u03cd\u03c3\u03b5\u03c4\u03b5 \u03c4\u03bf FOXO4-DRI \u03b5\u03c1\u03b5\u03c5\u03bd\u03b7\u03c4\u03b9\u03ba\u03ae\u03c2 \u03c7\u03c1\u03ae\u03c3\u03b7\u03c2:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">\u03a0\u03c9\u03bb\u03b5\u03af\u03c4\u03b1\u03b9 \u03c9\u03c2 \u03bb\u03c5\u03bf\u03c6\u03b9\u03bb\u03bf\u03c0\u03bf\u03b9\u03b7\u03bc\u03ad\u03bd\u03b7 \u03c3\u03ba\u03cc\u03bd\u03b7. \u03a6\u03c5\u03bb\u03ac\u03c3\u03c3\u03b5\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03b4\u03c1\u03bf\u03c3\u03b5\u03c1\u03cc, \u03c3\u03ba\u03bf\u03c4\u03b5\u03b9\u03bd\u03cc \u03bc\u03ad\u03c1\u03bf\u03c2 \u03c3\u03b5 \u03b8\u03b5\u03c1\u03bc\u03bf\u03ba\u03c1\u03b1\u03c3\u03af\u03b1 \u03b4\u03c9\u03bc\u03b1\u03c4\u03af\u03bf\u03c5 \u03ae \u03c3\u03c4\u03b7\u03bd \u03ba\u03b1\u03c4\u03ac\u03c8\u03c5\u03be\u03b7 \u03c3\u03c4\u03bf\u03c5\u03c2 -20\u00b0C \u03ae \u03c7\u03b1\u03bc\u03b7\u03bb\u03cc\u03c4\u03b5\u03c1\u03b1. \u0391\u03c0\u03bf\u03c6\u03b5\u03cd\u03b3\u03b5\u03c4\u03b5 \u03c4\u03bf\u03c5\u03c2 \u03ba\u03cd\u03ba\u03bb\u03bf\u03c5\u03c2 \u03ba\u03b1\u03c4\u03ac\u03c8\u03c5\u03be\u03b7\u03c2-\u03b1\u03c0\u03cc\u03c8\u03c5\u03be\u03b7\u03c2. \u03a0\u03c1\u03bf\u03c3\u03c4\u03b1\u03c4\u03b5\u03cd\u03c3\u03c4\u03b5 \u03b1\u03c0\u03cc \u03c4\u03bf \u03c6\u03c9\u03c2 \u03ba\u03b1\u03b9 \u03c4\u03b7\u03bd \u03c5\u03b3\u03c1\u03b1\u03c3\u03af\u03b1. \u0397 \u03b4\u03b9\u03ac\u03c1\u03ba\u03b5\u03b9\u03b1 \u03b6\u03c9\u03ae\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c3\u03c5\u03bd\u03ae\u03b8\u03c9\u03c2 2 \u03c7\u03c1\u03cc\u03bd\u03b9\u03b1 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03ba\u03b1\u03c4\u03b1\u03c3\u03ba\u03b5\u03c5\u03ae. \u039c\u03b5\u03c4\u03ac \u03c4\u03b7\u03bd \u03b1\u03bd\u03b1\u03c3\u03cd\u03c3\u03c4\u03b1\u03c3\u03b7, \u03c6\u03c5\u03bb\u03ac\u03be\u03c4\u03b5 \u03c4\u03bf \u03b4\u03b9\u03ac\u03bb\u03c5\u03bc\u03b1 \u03c3\u03c4\u03bf \u03c8\u03c5\u03b3\u03b5\u03af\u03bf \u03c3\u03c4\u03bf\u03c5\u03c2 2-8\u00b0C (\u03b4\u03b9\u03b1\u03c4\u03b7\u03c1\u03b5\u03af\u03c4\u03b1\u03b9 \u03b3\u03b9\u03b1 ~4 \u03b5\u03b2\u03b4\u03bf\u03bc\u03ac\u03b4\u03b5\u03c2).<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">\u0391\u03c6\u03ae\u03c3\u03c4\u03b5 \u03c4\u03b7 \u03c3\u03c6\u03c1\u03b1\u03b3\u03b9\u03c3\u03bc\u03ad\u03bd\u03b7 \u03c6\u03b9\u03ac\u03bb\u03b7 \u03bd\u03b1 \u03c6\u03c4\u03ac\u03c3\u03b5\u03b9 \u03c3\u03b5 \u03b8\u03b5\u03c1\u03bc\u03bf\u03ba\u03c1\u03b1\u03c3\u03af\u03b1 \u03b4\u03c9\u03bc\u03b1\u03c4\u03af\u03bf\u03c5 \u03c0\u03c1\u03b9\u03bd \u03c3\u03c6\u03ac\u03be\u03b5\u03c4\u03b5 \u03c4\u03b7 \u03c3\u03c6\u03c1\u03b1\u03b3\u03af\u03b4\u03b1, \u03ce\u03c3\u03c4\u03b5 \u03b7 \u03c5\u03b3\u03c1\u03b1\u03c3\u03af\u03b1 \u03c4\u03bf\u03c5 \u03c0\u03b5\u03c1\u03b9\u03b2\u03ac\u03bb\u03bb\u03bf\u03bd\u03c4\u03bf\u03c2 \u03bd\u03b1 \u03bc\u03b7\u03bd \u03c3\u03c5\u03bc\u03c0\u03c5\u03ba\u03bd\u03c9\u03b8\u03b5\u03af \u03c3\u03c4\u03b7 \u03c3\u03ba\u03cc\u03bd\u03b7.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">\u03a0\u03c1\u03bf\u03c3\u03b8\u03ad\u03c3\u03c4\u03b5 \u03c4\u03bf \u03b1\u03c1\u03b1\u03b9\u03c9\u03c4\u03b9\u03ba\u03cc \u03b1\u03c1\u03b3\u03ac \u03ba\u03b1\u03c4\u03ac \u03bc\u03ae\u03ba\u03bf\u03c2 \u03c4\u03bf\u03c5 \u03b5\u03c3\u03c9\u03c4\u03b5\u03c1\u03b9\u03ba\u03bf\u03cd \u03c4\u03bf\u03b9\u03c7\u03ce\u03bc\u03b1\u03c4\u03bf\u03c2 \u03c4\u03bf\u03c5 \u03c6\u03b9\u03b1\u03bb\u03b9\u03b4\u03af\u03bf\u03c5 \u03ba\u03b1\u03b9 \u03cc\u03c7\u03b9 \u03b1\u03c0\u03b5\u03c5\u03b8\u03b5\u03af\u03b1\u03c2 \u03c0\u03ac\u03bd\u03c9 \u03c3\u03c4\u03b7 \u03c3\u03c4\u03b5\u03c1\u03b5\u03ae \u03b4\u03cc\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03c3\u03ba\u03cc\u03bd\u03b7\u03c2.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">\u0391\u03bd\u03ac\u03bc\u03b9\u03be\u03b7. \u03a0\u03b5\u03c1\u03b9\u03c3\u03c4\u03c1\u03ad\u03c8\u03c4\u03b5 \u03b1\u03c0\u03b1\u03bb\u03ac \u03ae \u03b1\u03c6\u03ae\u03c3\u03c4\u03b5 \u03c4\u03bf \u03bd\u03b1 \u03b4\u03b9\u03b1\u03bb\u03c5\u03b8\u03b5\u03af \u03c7\u03c9\u03c1\u03af\u03c2 \u03b1\u03bd\u03b1\u03c4\u03ac\u03c1\u03b1\u03be\u03b7. \u03a0\u03bf\u03c4\u03ad \u03bc\u03b7\u03bd \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03b5\u03af\u03c4\u03b5 \u03b1\u03bd\u03b1\u03b4\u03b5\u03c5\u03c4\u03ae\u03c1\u03b1 \u03c4\u03cd\u03c0\u03bf\u03c5 vortex \u03bf\u03cd\u03c4\u03b5 \u03bd\u03b1 \u03c4\u03bf \u03b1\u03bd\u03b1\u03ba\u03b9\u03bd\u03b5\u03af\u03c4\u03b5. \u0397 \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03ba\u03ae \u03b4\u03b9\u03ac\u03c4\u03bc\u03b7\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03bf \u03b1\u03c6\u03c1\u03b9\u03c3\u03bc\u03cc\u03c2 \u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03c1\u03ad\u03c6\u03bf\u03c5\u03bd \u03c4\u03b1 \u03bc\u03b1\u03ba\u03c1\u03ac \u03c0\u03b5\u03c0\u03c4\u03af\u03b4\u03b9\u03b1.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">\u039c\u03bf\u03b9\u03c1\u03ac\u03c3\u03c4\u03b5 \u03c3\u03b5 \u03cc\u03b3\u03ba\u03bf\u03c5\u03c2 \u03bc\u03af\u03b1\u03c2 \u03c7\u03c1\u03ae\u03c3\u03b7\u03c2 \u03ba\u03b1\u03c4\u03ac \u03c4\u03b7\u03bd \u03b1\u03bd\u03b1\u03c3\u03cd\u03c3\u03c4\u03b1\u03c3\u03b7, \u03ce\u03c3\u03c4\u03b5 \u03c4\u03bf \u03b1\u03c0\u03bf\u03b8\u03b7\u03ba\u03b5\u03c5\u03bc\u03ad\u03bd\u03bf \u03c5\u03bb\u03b9\u03ba\u03cc \u03b5\u03c1\u03b3\u03b1\u03c3\u03af\u03b1\u03c2 \u03bd\u03b1 \u03bc\u03b7\u03bd \u03b5\u03c0\u03b1\u03bd\u03b1\u03ba\u03b1\u03c4\u03b1\u03c8\u03c5\u03c7\u03b8\u03b5\u03af \u03c0\u03bf\u03c4\u03ad. \u039f\u03b9 \u03b5\u03c0\u03b1\u03bd\u03b1\u03bb\u03b1\u03bc\u03b2\u03b1\u03bd\u03cc\u03bc\u03b5\u03bd\u03bf\u03b9 \u03ba\u03cd\u03ba\u03bb\u03bf\u03b9 \u03c8\u03cd\u03be\u03b7\u03c2-\u03c4\u03ae\u03be\u03b7\u03c2 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03bf\u03cd\u03bd \u03c4\u03b7\u03bd \u03ba\u03cd\u03c1\u03b9\u03b1 \u03b1\u03c0\u03bf\u03c4\u03c1\u03ad\u03c8\u03b9\u03bc\u03b7 \u03b1\u03b9\u03c4\u03af\u03b1 \u03b1\u03c0\u03ce\u03bb\u03b5\u03b9\u03b1\u03c2 \u03b4\u03c1\u03b1\u03c3\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2.<\/span><\/li>\n<\/ul>\n<h2><span style=\"font-weight: 400;\">\u03a3\u03c5\u03c7\u03bd\u03ad\u03c2 \u03b5\u03c1\u03c9\u03c4\u03ae\u03c3\u03b5\u03b9\u03c2 \u03b3\u03b9\u03b1 \u03c4\u03bf FOXO4-DRI<\/span><\/h2>\n<h3><span style=\"font-weight: 400;\">\u03a4ia \u03b5\u03af\u03bd\u03b1\u03b9 \u03c4\u03b1 \u03b3\u03b5\u03c1\u03b1\u03c3\u03bc\u03ad\u03bd\u03b1 \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1;<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">\u03a3uy\u03bd\u03b7\u03c3\u03bc\u03ad\u03bd\u03bf\u03b9 \u03b1\u03bb\u03bb\u03ac \u03b6\u03c9\u03bd\u03c4\u03b1\u03bd\u03cc\u03c2, \u03b1\u03ba\u03cc\u03bc\u03b1 \u03b5\u03ba\u03ba\u03c1\u03af\u03bd\u03bf\u03c5\u03bd. \u039a\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03c0\u03bf\u03c5 \u03bf\u03c5\u03c3\u03b9\u03b1\u03c3\u03c4\u03b9\u03ba\u03ac \u03ba\u03c1\u03b1\u03c4\u03b9\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03ba\u03b1\u03b9 \u03b1\u03bd\u03c4\u03b9\u03c3\u03c4\u03ad\u03ba\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b7\u03bd \u03b1\u03c0\u03cc\u03c0\u03c4\u03c9\u03c3\u03b7.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">\u03a4\u03bf \u03bc\u03bf\u03bd\u03bf\u03c0\u03ac\u03c4\u03b9 FOXO4-p53 \u03ba\u03b1\u03b9 \u03b3\u03b9\u03b1\u03c4\u03af \u03ad\u03c7\u03b5\u03b9 \u03c3\u03b7\u03bc\u03b1\u03c3\u03af\u03b1 \u03b5\u03b4\u03ce;<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">\u0397 FOXO4 \u03b5\u03af\u03bd\u03b1\u03b9 \u03bc\u03b9\u03b1 \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7 \u03c0\u03bf\u03c5 \u03c3\u03c5\u03bd\u03b4\u03ad\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03c4\u03b7\u03bd p53, \u03bc\u03b9\u03b1 \u03ac\u03bb\u03bb\u03b7 \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7 \u03c3\u03b5 \u03ad\u03bd\u03b1 \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03bf. \u03a3\u03c4\u03b7 \u03c3\u03c5\u03bd\u03ad\u03c7\u03b5\u03b9\u03b1, \u201c\u03c3\u03c5\u03b3\u03ba\u03c1\u03b1\u03c4\u03b5\u03af\u201d \u03c4\u03b7\u03bd p53 \u03c3\u03c4\u03bf\u03bd \u03c0\u03c5\u03c1\u03ae\u03bd\u03b1. \u0391\u03c5\u03c4\u03cc \u03b5\u03bc\u03c0\u03bf\u03b4\u03af\u03b6\u03b5\u03b9 \u03c4\u03b7\u03bd p53 \u03bd\u03b1 \u03c0\u03ac\u03b5\u03b9 \u03c3\u03c4\u03b1 \u03bc\u03b9\u03c4\u03bf\u03c7\u03cc\u03bd\u03b4\u03c1\u03b9\u03b1 \u03ba\u03b1\u03b9 \u03bd\u03b1 \u03c3\u03c4\u03b5\u03af\u03bb\u03b5\u03b9 \u03ad\u03bd\u03b1 \u03c3\u03ae\u03bc\u03b1 \u03b3\u03b9\u03b1 \u03b1\u03c0\u03cc\u03c0\u03c4\u03c9\u03c3\u03b7 (\u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03cc \u03b8\u03ac\u03bd\u03b1\u03c4\u03bf). \u0388\u03c4\u03c3\u03b9 \u03c4\u03b1 \u03b3\u03b7\u03c1\u03b1\u03c3\u03bc\u03ad\u03bd\u03b1 \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03bf \u03b1\u03bd\u03c4\u03b9\u03c3\u03c4\u03ad\u03ba\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03c4\u03bf\u03bd \u03b8\u03ac\u03bd\u03b1\u03c4\u03bf, \u03c0\u03b1\u03c1\u03cc\u03bb\u03bf \u03c0\u03bf\u03c5 \u03b4\u03b5\u03bd \u03b4\u03b9\u03b1\u03b9\u03c1\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03c0\u03bb\u03ad\u03bf\u03bd \u03ba\u03b1\u03b9 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c0\u03c1\u03bf\u03b5\u03c4\u03bf\u03b9\u03bc\u03b1\u03c3\u03bc\u03ad\u03bd\u03b1 \u03bd\u03b1 \u03c0\u03b5\u03b8\u03ac\u03bd\u03bf\u03c5\u03bd.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">\u0388\u03c7\u03b5\u03b9 \u03b4\u03bf\u03ba\u03b9\u03bc\u03b1\u03c3\u03c4\u03b5\u03af \u03c4\u03bf FOXO4-DRI \u03c3\u03b5 \u03b1\u03bd\u03b8\u03c1\u03ce\u03c0\u03bf\u03c5\u03c2;<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">\u038c\u03c7\u03b9. \u0395\u03c0\u03af\u03c3\u03b7\u03c2, \u03b7 \u03b1\u03bd\u03b1\u03c0\u03c4\u03cd\u03be\u03bf\u03c5\u03c3\u03b1 \u03b5\u03c4\u03b1\u03b9\u03c1\u03b5\u03af\u03b1 \u03ba\u03b1\u03b9 \u03c4\u03bf \u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03ae\u03c1\u03b9\u03bf \u03c0\u03c1\u03bf\u03ad\u03bb\u03b5\u03c5\u03c3\u03b7\u03c2 \u03ad\u03c7\u03bf\u03c5\u03bd \u03c3\u03c4\u03c1\u03b1\u03c6\u03b5\u03af \u03c3\u03b5 \u03b5\u03bd\u03ce\u03c3\u03b5\u03b9\u03c2 \u03b5\u03c0\u03cc\u03bc\u03b5\u03bd\u03b7\u03c2 \u03b3\u03b5\u03bd\u03b9\u03ac\u03c2 \u03bc\u03b5 \u03b2\u03b5\u03bb\u03c4\u03b9\u03c9\u03bc\u03ad\u03bd\u03b1 \u03c0\u03c1\u03bf\u03c6\u03af\u03bb \u03b1\u03c3\u03c6\u03ac\u03bb\u03b5\u03b9\u03b1\u03c2.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">\u03a0\u03ce\u03c2 \u03b4\u03b9\u03b1\u03c6\u03ad\u03c1\u03b5\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b1 \u03b1\u03c0\u03cc \u03c4\u03bf\u03c5 \u03c3\u03c4\u03cc\u03bc\u03b1\u03c4\u03bf\u03c2 \u03b3\u03b7\u03c1\u03bf\u03bb\u03c5\u03c4\u03b9\u03ba\u03ac (senolytics) \u03cc\u03c0\u03c9\u03c2 \u03b7 \u03c6\u03b9\u03c3\u03b5\u03c4\u03af\u03bd\u03b7 \u03ae \u03b7 \u03ba\u03bf\u03c5\u03b5\u03c1\u03ba\u03b5\u03c4\u03af\u03bd\u03b7;<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">\u0394\u03b9\u03b1\u03c6\u03bf\u03c1\u03b5\u03c4\u03b9\u03ba\u03cc\u03c2 \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03cc\u03c2, \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03b5\u03c4\u03b9\u03ba\u03ae \u03c7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03b7 \u03ba\u03b1\u03b9, \u03c3\u03b5 \u03b1\u03bd\u03c4\u03af\u03b8\u03b5\u03c3\u03b7 \u03bc\u03b5 \u03b5\u03ba\u03b5\u03af\u03bd\u03b1, \u03ba\u03b1\u03b8\u03cc\u03bb\u03bf\u03c5 \u03b4\u03b5\u03b4\u03bf\u03bc\u03ad\u03bd\u03b1 \u03b1\u03c0\u03cc \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ad\u03c2 \u03b4\u03bf\u03ba\u03b9\u03bc\u03ad\u03c2 \u03c3\u03b5 \u03b1\u03bd\u03b8\u03c1\u03ce\u03c0\u03bf\u03c5\u03c2. \u0394\u03b5\u03af\u03c4\u03b5 \u03c4\u03b7\u03bd \u03b5\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1 \u201cFOXO4-DRI \u03ad\u03bd\u03b1\u03bd\u03c4\u03b9 \u03ac\u03bb\u03bb\u03c9\u03bd \u03c3\u03b5\u03bd\u03bf\u03bb\u03c5\u03c4\u03b9\u03ba\u03ce\u03bd\u201d \u03c0\u03b1\u03c1\u03b1\u03c0\u03ac\u03bd\u03c9.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">\u0393\u03b9\u03b1\u03c4\u03af \u03b7 \u03b5\u03c0\u03b9\u03bb\u03b5\u03ba\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03af \u03b5\u03c1\u03b5\u03c5\u03bd\u03b7\u03c4\u03b9\u03ba\u03cc \u03b5\u03c1\u03ce\u03c4\u03b7\u03bc\u03b1 \u03ba\u03b1\u03b9 \u03cc\u03c7\u03b9 \u03ad\u03bd\u03b1 \u03b4\u03b5\u03b4\u03bf\u03bc\u03ad\u03bd\u03bf \u03b3\u03b5\u03b3\u03bf\u03bd\u03cc\u03c2;<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">\u0395\u03c0\u03b5\u03b9\u03b4\u03ae \u03b5\u03be\u03b1\u03c1\u03c4\u03ac\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03bf \u03b3\u03b5\u03b3\u03bf\u03bd\u03cc\u03c2 \u03cc\u03c4\u03b9 \u03c4\u03bf FOXO4 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03bf \u03c3\u03c4\u03b1 \u03b3\u03b7\u03c1\u03b1\u03c3\u03bc\u03ad\u03bd\u03b1 \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03ba\u03b1\u03b9 \u03c7\u03b1\u03bc\u03b7\u03bb\u03cc \u03b1\u03bb\u03bb\u03bf\u03cd, \u03b5\u03c0\u03b5\u03b9\u03b4\u03ae \u03bf\u03c1\u03b9\u03c3\u03bc\u03ad\u03bd\u03bf\u03b9 \u03c0\u03bb\u03b7\u03b8\u03c5\u03c3\u03bc\u03bf\u03af \u03b3\u03b7\u03c1\u03b1\u03c3\u03bc\u03ad\u03bd\u03c9\u03bd \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03c9\u03bd \u03c6\u03b1\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03bd\u03b1 \u03b5\u03be\u03c5\u03c0\u03b7\u03c1\u03b5\u03c4\u03bf\u03cd\u03bd \u03c0\u03c1\u03bf\u03c3\u03c4\u03b1\u03c4\u03b5\u03c5\u03c4\u03b9\u03ba\u03ad\u03c2 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b5\u03c2, \u03ba\u03b1\u03b9 \u03b5\u03c0\u03b5\u03b9\u03b4\u03ae \u03c4\u03bf\u03c5\u03bb\u03ac\u03c7\u03b9\u03c3\u03c4\u03bf\u03bd \u03bc\u03af\u03b1 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7 \u03b4\u03b9\u03b1\u03c0\u03af\u03c3\u03c4\u03c9\u03c3\u03b5 \u03cc\u03c4\u03b9 \u03b7 \u03c3\u03b5\u03bd\u03bf\u03bb\u03c5\u03c4\u03b9\u03ba\u03ae \u03ba\u03ac\u03b8\u03b1\u03c1\u03c3\u03b7 \u03b5\u03c0\u03b9\u03b4\u03b5\u03af\u03bd\u03c9\u03c3\u03b5 \u03c4\u03b1 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03ad\u03c3\u03bc\u03b1\u03c4\u03b1 \u03c3\u03b5 \u03ad\u03bd\u03b1 \u03c3\u03c5\u03b3\u03ba\u03b5\u03ba\u03c1\u03b9\u03bc\u03ad\u03bd\u03bf \u03b1\u03b3\u03b3\u03b5\u03b9\u03b1\u03ba\u03cc \u03c0\u03bb\u03b1\u03af\u03c3\u03b9\u03bf.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">\u03a3\u03b5 \u03c4\u03b9 \u03c0\u03c1\u03bf\u03bf\u03c1\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c5\u03c4\u03cc \u03c4\u03bf \u03c0\u03c1\u03bf\u03ca\u03cc\u03bd;<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">\u039c\u03cc\u03bd\u03bf \u03b3\u03b9\u03b1 \u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03b7\u03c1\u03b9\u03b1\u03ba\u03ae \u03ad\u03c1\u03b5\u03c5\u03bd\u03b1. \u0391\u03ba\u03b1\u03c4\u03ac\u03bb\u03bb\u03b7\u03bb\u03bf \u03b3\u03b9\u03b1 \u03b1\u03bd\u03b8\u03c1\u03ce\u03c0\u03b9\u03bd\u03b7 \u03ae \u03ba\u03c4\u03b7\u03bd\u03b9\u03b1\u03c4\u03c1\u03b9\u03ba\u03ae \u03c7\u03c1\u03ae\u03c3\u03b7, \u03b4\u03b5\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03c3\u03c5\u03bc\u03c0\u03bb\u03ae\u03c1\u03c9\u03bc\u03b1 \u03b4\u03b9\u03b1\u03c4\u03c1\u03bf\u03c6\u03ae\u03c2, \u03b4\u03b5\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03bf, \u03b4\u03b5\u03bd \u03c0\u03c1\u03bf\u03bf\u03c1\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03b3\u03b9\u03b1 \u03b4\u03b9\u03b1\u03b3\u03bd\u03c9\u03c3\u03c4\u03b9\u03ba\u03ae \u03ae \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03c4\u03b9\u03ba\u03ae \u03b5\u03c6\u03b1\u03c1\u03bc\u03bf\u03b3\u03ae.<\/span><\/p>\n<p>&nbsp;<\/p>\n<h2><span style=\"font-weight: 400;\">\u03a3\u03c0\u03bf\u03c5\u03b4\u03ad\u03c2<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">\u03a3\u03c4\u03cc\u03c7\u03b5\u03c5\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b1\u03c0\u03cc\u03c0\u03c4\u03c9\u03c3\u03b7\u03c2 \u03c4\u03c9\u03bd \u03b3\u03b7\u03c1\u03b1\u03c3\u03bc\u03ad\u03bd\u03c9\u03bd \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03b1\u03c0\u03bf\u03ba\u03b1\u03b8\u03b9\u03c3\u03c4\u03ac \u03c4\u03b7\u03bd \u03b9\u03c3\u03c4\u03b9\u03ba\u03ae \u03bf\u03bc\u03bf\u03b9\u03bf\u03c3\u03c4\u03b1\u03c3\u03b7 \u03c9\u03c2 \u03b1\u03c0\u03cc\u03ba\u03c1\u03b9\u03c3\u03b7 \u03c3\u03c4\u03b7 \u03c7\u03b7\u03bc\u03b5\u03b9\u03bf\u03c4\u03bf\u03be\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1 \u03ba\u03b1\u03b9 \u03c4\u03b7 \u03b3\u03ae\u03c1\u03b1\u03bd\u03c3\u03b7 <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/28340339\/\" target=\"_blank\" rel=\"noopener\">https:\/\/pubmed.ncbi.nlm.nih.gov\/28340339\/\u00a0<\/a><\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u0397 \u03b1\u03c0\u03bf\u03bc\u03ac\u03ba\u03c1\u03c5\u03bd\u03c3\u03b7 \u03c4\u03c9\u03bd \u03b8\u03b5\u03c4\u03b9\u03ba\u03ce\u03bd \u03c3\u03b5 p16Ink4a \u03b3\u03b5\u03c1\u03b1\u03c3\u03bc\u03ad\u03bd\u03c9\u03bd \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03ba\u03b1\u03b8\u03c5\u03c3\u03c4\u03b5\u03c1\u03b5\u03af \u03c4\u03b9\u03c2 \u03b4\u03b9\u03b1\u03c4\u03b1\u03c1\u03b1\u03c7\u03ad\u03c2 \u03c0\u03bf\u03c5 \u03c3\u03c7\u03b5\u03c4\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03c4\u03b7 \u03b3\u03ae\u03c1\u03b1\u03bd\u03c3\u03b7 <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/22048312\/\" target=\"_blank\" rel=\"noopener\">https:\/\/pubmed.ncbi.nlm.nih.gov\/22048312\/\u00a0<\/a><\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u039f \u03c3\u03c7\u03b5\u03c4\u03b9\u03b6\u03cc\u03bc\u03b5\u03bd\u03bf\u03c2 \u03bc\u03b5 \u03c4\u03b7 \u03b3\u03ae\u03c1\u03b1\u03bd\u03c3\u03b7 \u03b5\u03ba\u03ba\u03c1\u03b9\u03c4\u03b9\u03ba\u03cc\u03c2 \u03c6\u03b1\u03b9\u03bd\u03cc\u03c4\u03c5\u03c0\u03bf\u03c2: \u03b7 \u03c3\u03ba\u03bf\u03c4\u03b5\u03b9\u03bd\u03ae \u03c0\u03bb\u03b5\u03c5\u03c1\u03ac \u03c4\u03b7\u03c2 \u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03bf\u03bb\u03ae\u03c2 \u03c4\u03c9\u03bd \u03cc\u03b3\u03ba\u03c9\u03bd \u2013 <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/20078217\/\" target=\"_blank\" rel=\"noopener\">https:\/\/pubmed.ncbi.nlm.nih.gov\/20078217\/<\/a><\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u03a4\u03bf FOXO4-DRI \u03bc\u03b5\u03c4\u03c1\u03b9\u03ac\u03b6\u03b5\u03b9 \u03c4\u03b7\u03bd \u03b1\u03bd\u03b5\u03c0\u03ac\u03c1\u03ba\u03b5\u03b9\u03b1 \u03ad\u03ba\u03ba\u03c1\u03b9\u03c3\u03b7\u03c2 \u03c4\u03b5\u03c3\u03c4\u03bf\u03c3\u03c4\u03b5\u03c1\u03cc\u03bd\u03b7\u03c2 \u03c0\u03bf\u03c5 \u03c3\u03c7\u03b5\u03c4\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03c4\u03b7\u03bd \u03b7\u03bb\u03b9\u03ba\u03af\u03b1, \u03c3\u03c4\u03bf\u03c7\u03b5\u03cd\u03bf\u03bd\u03c4\u03b1\u03c2 \u03c4\u03b1 \u03b3\u03b7\u03c1\u03b1\u03c3\u03bc\u03ad\u03bd\u03b1 \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 Leydig \u03c3\u03b5 \u03b7\u03bb\u03b9\u03ba\u03b9\u03c9\u03bc\u03ad\u03bd\u03b1 \u03c0\u03bf\u03bd\u03c4\u03af\u03ba\u03b9\u03b1 <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7053614\/\" target=\"_blank\" rel=\"noopener\">https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7053614\/<\/a><\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u0393\u03ae\u03c1\u03b1\u03bd\u03c3\u03b7-\u03bb\u03c5\u03c4\u03b9\u03ba\u03cc \u03a0\u03b5\u03c0\u03c4\u03af\u03b4\u03b9\u03bf FOXO4-DRI \u0391\u03c6\u03b1\u03b9\u03c1\u03b5\u03af \u0395\u03c0\u03b9\u03bb\u03b5\u03ba\u03c4\u03b9\u03ba\u03ac \u03c4\u03b1 \u0393\u03b7\u03c1\u03b1\u03c3\u03bc\u03ad\u03bd\u03b1 \u039a\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03b1\u03c0\u03cc in vitro \u0395\u03c0\u03b5\u03ba\u03c4\u03b1\u03bc\u03ad\u03bd\u03b1 \u0391\u03bd\u03b8\u03c1\u03ce\u03c0\u03b9\u03bd\u03b1 \u03a7\u03bf\u03bd\u03b4\u03c1\u03bf\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33996787\/\" target=\"_blank\" rel=\"noopener\">https:\/\/pubmed.ncbi.nlm.nih.gov\/33996787\/\u00a0<\/a><\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u03a4\u03bf \u03c0\u03b5\u03c0\u03c4\u03af\u03b4\u03b9\u03bf FOXO4 \u03c3\u03c4\u03bf\u03c7\u03b5\u03cd\u03b5\u03b9 \u03c4\u03bf\u03c5\u03c2 \u03bc\u03c5\u03bf\u03ca\u03bd\u03bf\u03b2\u03bb\u03ac\u03c3\u03c4\u03b5\u03c2 \u03ba\u03b1\u03b9 \u03b2\u03b5\u03bb\u03c4\u03b9\u03ce\u03bd\u03b5\u03b9 \u03c4\u03b7\u03bd \u03b5\u03c0\u03b1\u03b3\u03cc\u03bc\u03b5\u03bd\u03b7 \u03b1\u03c0\u03cc \u03b2\u03bb\u03b5\u03bf\u03bc\u03c5\u03ba\u03af\u03bd\u03b7 \u03c0\u03bd\u03b5\u03c5\u03bc\u03bf\u03bd\u03b9\u03ba\u03ae \u03af\u03bd\u03c9\u03c3\u03b7 \u03c3\u03b5 \u03c0\u03bf\u03bd\u03c4\u03af\u03ba\u03b9\u03b1 \u03bc\u03ad\u03c3\u03c9 \u03c4\u03b7\u03c2 \u03bf\u03b4\u03bf\u03cd \u03b1\u03bb\u03bb\u03b7\u03bb\u03b5\u03c0\u03af\u03b4\u03c1\u03b1\u03c3\u03b7\u03c2 \u03b5\u03be\u03c9cellular matrix (ECM)-\u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03b1 <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35510614\/\" target=\"_blank\" rel=\"noopener\">https:\/\/pubmed.ncbi.nlm.nih.gov\/35510614\/\u00a0<\/a><\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u03a4\u03bf FOXO4-DRI \u03b2\u03b5\u03bb\u03c4\u03b9\u03ce\u03bd\u03b5\u03b9 \u03c4\u03b7 \u03c3\u03c0\u03b5\u03c1\u03bc\u03b1\u03c4\u03bf\u03b3\u03ad\u03bd\u03b5\u03c3\u03b7 \u03c3\u03b5 \u03b7\u03bb\u03b9\u03ba\u03b9\u03c9\u03bc\u03ad\u03bd\u03b1 \u03c0\u03bf\u03bd\u03c4\u03af\u03ba\u03b9\u03b1 \u03bc\u03ad\u03c3\u03c9 \u03c4\u03b7\u03c2 \u03bc\u03b5\u03af\u03c9\u03c3\u03b7\u03c2 \u03c4\u03b7\u03c2 \u03ad\u03ba\u03ba\u03c1\u03b9\u03c3\u03b7\u03c2 \u03c4\u03bf\u03c5 \u03c6\u03b1\u03b9\u03bd\u03bf\u03c4\u03cd\u03c0\u03bf\u03c5 \u03ad\u03ba\u03ba\u03c1\u03b9\u03c3\u03b7\u03c2 \u03c0\u03bf\u03c5 \u03c3\u03c7\u03b5\u03c4\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03c4\u03b7 \u03b3\u03ae\u03c1\u03b1\u03bd\u03c3\u03b7 \u03b1\u03c0\u03cc \u03c4\u03b1 \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 Leydig<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39025385\/\" target=\"_blank\" rel=\"noopener\"> https:\/\/pubmed.ncbi.nlm.nih.gov\/39025385\/<\/a><\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u03a4\u03bf FOXO4-DRI \u03c1\u03c5\u03b8\u03bc\u03af\u03b6\u03b5\u03b9 \u03c4\u03b7 \u03b3\u03ae\u03c1\u03b1\u03bd\u03c3\u03b7 \u03c4\u03c9\u03bd \u03b5\u03bd\u03b4\u03bf\u03b8\u03b7\u03bb\u03b9\u03b1\u03ba\u03ce\u03bd \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03bc\u03ad\u03c3\u03c9 \u03c4\u03b7\u03c2 \u03bf\u03b4\u03bf\u03cd \u03c3\u03b7\u03bc\u03b1\u03c4\u03bf\u03b4\u03cc\u03c4\u03b7\u03c3\u03b7\u03c2 P53 <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41625068\/\" target=\"_blank\" rel=\"noopener\">https:\/\/pubmed.ncbi.nlm.nih.gov\/41625068\/\u00a0<\/a><\/span><\/p>","protected":false},"excerpt":{"rendered":"<p><span style=\"font-weight: 400;\"><strong>FOXO4<\/strong> \u03b5\u03af\u03bd\u03b1\u03b9 \u03bc\u03b9\u03b1 \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7 \u03c0\u03bf\u03c5 \u03c3\u03c5\u03bd\u03b4\u03ad\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03c4\u03b7\u03bd p53 \u03b5\u03bd\u03c4\u03cc\u03c2 \u03b5\u03bd\u03cc\u03c2 \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03bf\u03c5, \u03b3\u03b5\u03b3\u03bf\u03bd\u03cc\u03c2 \u03c0\u03bf\u03c5 \u03b5\u03bc\u03c0\u03bf\u03b4\u03af\u03b6\u03b5\u03b9 \u03c4\u03b1 \u03c3\u03ae\u03bc\u03b1\u03c4\u03b1 \u03c5\u03c0\u03ad\u03c1 \u03c4\u03bf\u03c5 \u03b8\u03b1\u03bd\u03ac\u03c4\u03bf\u03c5 \u03c3\u03c4\u03b1 \u03b3\u03b7\u03c1\u03b1\u03c3\u03bc\u03ad\u03bd\u03b1 (senescent) \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1. \u0391\u03c5\u03c4\u03cc \u03b1\u03c0\u03bf\u03c4\u03c1\u03ad\u03c0\u03b5\u03b9 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03ac \u03c4\u03b1 \u03b3\u03b7\u03c1\u03b1\u03c3\u03bc\u03ad\u03bd\u03b1 \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03b1\u03c0\u03cc \u03c4\u03bf \u03bd\u03b1 \u03c0\u03b5\u03b8\u03ac\u03bd\u03bf\u03c5\u03bd. \u039c\u03cc\u03bb\u03b9\u03c2 \u03c3\u03c5\u03bd\u03b4\u03b5\u03b8\u03b5\u03af, \u03b7 FOXO4 \u03b5\u03bc\u03c0\u03bf\u03b4\u03af\u03b6\u03b5\u03b9 \u03c4\u03b7\u03bd p53 \u03bd\u03b1 \u03b1\u03c0\u03b5\u03bb\u03b5\u03c5\u03b8\u03b5\u03c1\u03ce\u03c3\u03b5\u03b9 \u03c3\u03ae\u03bc\u03b1\u03c4\u03b1 \u03cc\u03c0\u03c9\u03c2 \u03b7 BAX \u03c0\u03bf\u03c5 \u03b8\u03b1 \u03bf\u03b4\u03b7\u03b3\u03bf\u03cd\u03c3\u03b1\u03bd \u03c3\u03b5 \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03ae \u03b1\u03c5\u03c4\u03bf\u03ba\u03c4\u03bf\u03bd\u03af\u03b1 (\u03b1\u03c0\u03cc\u03c0\u03c4\u03c9\u03c3\u03b7). <\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u0391\u03bb\u03bb\u03ac \u03b1\u03bd \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03c3\u03b1\u03c4\u03b5 \u03bd\u03b1 \u03b4\u03b9\u03b1\u03bb\u03cd\u03c3\u03b5\u03c4\u03b5 \u03b1\u03c5\u03c4\u03cc\u03bd \u03c4\u03bf\u03bd \u03b4\u03b5\u03c3\u03bc\u03cc, \u03c4\u03bf \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03bf \u03b5\u03af\u03bd\u03b1\u03b9 \u03c0\u03bb\u03ad\u03bf\u03bd \u03b5\u03bb\u03b5\u03cd\u03b8\u03b5\u03c1\u03bf \u03bd\u03b1 \u03b1\u03c0\u03b5\u03bb\u03b5\u03c5\u03b8\u03b5\u03c1\u03ce\u03c3\u03b5\u03b9 \u03c3\u03ae\u03bc\u03b1\u03c4\u03b1 \u03c5\u03c0\u03ad\u03c1 \u03c4\u03bf\u03c5 \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03bf\u03cd \u03b8\u03b1\u03bd\u03ac\u03c4\u03bf\u03c5. \u03a4\u03bf FOXO4-DRI \u03b5\u03af\u03bd\u03b1\u03b9 \u03ad\u03bd\u03b1 \u03c0\u03b5\u03c0\u03c4\u03af\u03b4\u03b9\u03bf \u03c0\u03bf\u03c5 \u03ba\u03ac\u03bd\u03b5\u03b9 \u03b1\u03ba\u03c1\u03b9\u03b2\u03ce\u03c2 \u03b1\u03c5\u03c4\u03cc \u2013 \u03b4\u03b9\u03b1\u03bb\u03cd\u03b5\u03b9 \u03b1\u03c5\u03c4\u03cc\u03bd \u03c4\u03bf\u03bd \u03b4\u03b5\u03c3\u03bc\u03cc. \u0391\u03c5\u03c4\u03cc, \u03bc\u03b5 \u03c4\u03b7 \u03c3\u03b5\u03b9\u03c1\u03ac \u03c4\u03bf\u03c5, \u03ba\u03ac\u03bd\u03b5\u03b9 \u03c4\u03b7\u03bd p53 \u03bd\u03b1 \u03bc\u03b5\u03c4\u03b1\u03ba\u03b9\u03bd\u03b7\u03b8\u03b5\u03af \u03ad\u03be\u03c9 \u03b1\u03c0\u03cc \u03c4\u03bf\u03bd \u03c0\u03c5\u03c1\u03ae\u03bd\u03b1, \u03b5\u03be\u03bf\u03bd\u03c4\u03ce\u03bd\u03bf\u03bd\u03c4\u03b1\u03c2 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03ac \u03c4\u03b1 \u03b3\u03b5\u03c1\u03b1\u03c3\u03bc\u03ad\u03bd\u03b1 \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1. \u03a9\u03c2 \u03b5\u03ba \u03c4\u03bf\u03cd\u03c4\u03bf\u03c5, \u03c4\u03bf FOXO4-DRI \u03bc\u03b5\u03bb\u03b5\u03c4\u03ac\u03c4\u03b1\u03b9 \u03b3\u03b9\u03b1 \u03b1\u03bd\u03c4\u03b9\u03b3\u03b7\u03c1\u03b1\u03bd\u03c4\u03b9\u03ba\u03ac \u03bf\u03c6\u03ad\u03bb\u03b7 \u03c3\u03b5 \u03c0\u03bf\u03bd\u03c4\u03af\u03ba\u03b9\u03b1 (\u03b4\u03b5\u03bd \u03c5\u03c0\u03ac\u03c1\u03c7\u03bf\u03c5\u03bd \u03b4\u03b5\u03b4\u03bf\u03bc\u03ad\u03bd\u03b1 \u03b1\u03c0\u03cc \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ad\u03c2 \u03b4\u03bf\u03ba\u03b9\u03bc\u03ad\u03c2 \u03c3\u03b5 \u03b1\u03bd\u03b8\u03c1\u03ce\u03c0\u03bf\u03c5\u03c2).<\/span><\/p>","protected":false},"featured_media":15060,"template":"","meta":{"_acf_changed":false,"ub_ctt_via":""},"product_brand":[],"product_cat":[52,46,54],"product_tag":[],"class_list":["post-15058","product","type-product","status-publish","has-post-thumbnail","product_cat-anti-inflammatory-response-research-peptides","product_cat-peptides-for-longevity-research","product_cat-peptides-for-tissue-healing-research","first","instock","shipping-taxable","purchasable","product-type-simple"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v22.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Buy FOXO4-DRI 2mg (99% Purity) - CellPeptides<\/title>\n<meta name=\"description\" content=\"Buy FOXO4-DRI for senescence and longevity research, 99% purity, HPLC-tested. Click here to check availability and order today.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/cellpeptides.com\/el\/product\/buy-tesamorelin-5mg\/\" \/>\n<meta property=\"og:locale\" content=\"el_GR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Buy FOXO4-DRI 2mg (99% Purity) - CellPeptides\" \/>\n<meta property=\"og:description\" content=\"Buy FOXO4-DRI for senescence and longevity research, 99% purity, HPLC-tested. Click here to check availability and order today.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/cellpeptides.com\/el\/product\/buy-tesamorelin-5mg\/\" \/>\n<meta property=\"og:site_name\" content=\"CellPeptides\" \/>\n<meta property=\"article:modified_time\" content=\"2026-08-12T10:25:58+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/cellpeptides.com\/wp-content\/uploads\/2026\/08\/FOXO4-DRI-2mg_mockup.png\" \/>\n\t<meta property=\"og:image:width\" content=\"1200\" \/>\n\t<meta property=\"og:image:height\" content=\"1200\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"\u0395\u03ba\u03c4\u03b9\u03bc\u03ce\u03bc\u03b5\u03bd\u03bf\u03c2 \u03c7\u03c1\u03cc\u03bd\u03bf\u03c2 \u03b1\u03bd\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7\u03c2\" \/>\n\t<meta name=\"twitter:data1\" content=\"10 \u03bb\u03b5\u03c0\u03c4\u03ac\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/cellpeptides.com\/product\/buy-foxo4-dri-2mg\/\",\"url\":\"https:\/\/cellpeptides.com\/product\/buy-tesamorelin-5mg\/\",\"name\":\"Buy FOXO4-DRI 2mg (99% Purity) - CellPeptides\",\"isPartOf\":{\"@id\":\"https:\/\/cellpeptides.com\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/cellpeptides.com\/product\/buy-tesamorelin-5mg\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/cellpeptides.com\/product\/buy-tesamorelin-5mg\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/cellpeptides.com\/wp-content\/uploads\/2026\/08\/FOXO4-DRI-2mg_mockup.png\",\"datePublished\":\"2026-08-12T10:09:36+00:00\",\"dateModified\":\"2026-08-12T10:25:58+00:00\",\"description\":\"Buy FOXO4-DRI for senescence and longevity research, 99% purity, HPLC-tested. Click here to check availability and order today.\",\"breadcrumb\":{\"@id\":\"https:\/\/cellpeptides.com\/product\/buy-tesamorelin-5mg\/#breadcrumb\"},\"inLanguage\":\"el\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/cellpeptides.com\/product\/buy-tesamorelin-5mg\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"el\",\"@id\":\"https:\/\/cellpeptides.com\/product\/buy-tesamorelin-5mg\/#primaryimage\",\"url\":\"https:\/\/cellpeptides.com\/wp-content\/uploads\/2026\/08\/FOXO4-DRI-2mg_mockup.png\",\"contentUrl\":\"https:\/\/cellpeptides.com\/wp-content\/uploads\/2026\/08\/FOXO4-DRI-2mg_mockup.png\",\"width\":1200,\"height\":1200,\"caption\":\"FOXO4-DRI 2mg_mockup\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/cellpeptides.com\/product\/buy-tesamorelin-5mg\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/cellpeptides.com\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Shop\",\"item\":\"https:\/\/cellpeptides.com\/shop\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"FOXO4-DRI 2mg\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/cellpeptides.com\/#website\",\"url\":\"https:\/\/cellpeptides.com\/\",\"name\":\"CellPeptides\",\"description\":\"\",\"publisher\":{\"@id\":\"https:\/\/cellpeptides.com\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/cellpeptides.com\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"el\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/cellpeptides.com\/#organization\",\"name\":\"CellPeptides\",\"url\":\"https:\/\/cellpeptides.com\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"el\",\"@id\":\"https:\/\/cellpeptides.com\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/cellpeptides.com\/wp-content\/uploads\/2025\/02\/CellPeptides-logo2-lc2.png\",\"contentUrl\":\"https:\/\/cellpeptides.com\/wp-content\/uploads\/2025\/02\/CellPeptides-logo2-lc2.png\",\"width\":697,\"height\":152,\"caption\":\"CellPeptides\"},\"image\":{\"@id\":\"https:\/\/cellpeptides.com\/#\/schema\/logo\/image\/\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"\u0391\u03b3\u03bf\u03c1\u03ac\u03c3\u03c4\u03b5 FOXO4-DRI 2 mg (\u03ba\u03b1\u03b8\u03b1\u03c1\u03cc\u03c4\u03b7\u03c4\u03b1 99%) - CellPeptides","description":"\u0391\u03b3\u03bf\u03c1\u03ac\u03c3\u03c4\u03b5 FOXO4-DRI \u03b3\u03b9\u03b1 \u03ad\u03c1\u03b5\u03c5\u03bd\u03b1 \u03c3\u03c7\u03b5\u03c4\u03b9\u03ba\u03ac \u03bc\u03b5 \u03c4\u03b7 \u03b3\u03ae\u03c1\u03b1\u03bd\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03c4\u03b7 \u03bc\u03b1\u03ba\u03c1\u03bf\u03b6\u03c9\u03af\u03b1, \u03ba\u03b1\u03b8\u03b1\u03c1\u03cc\u03c4\u03b7\u03c4\u03b1 99%, \u03b5\u03bb\u03b5\u03b3\u03bc\u03ad\u03bd\u03bf \u03bc\u03b5 HPLC. \u039a\u03ac\u03bd\u03c4\u03b5 \u03ba\u03bb\u03b9\u03ba \u03b5\u03b4\u03ce \u03b3\u03b9\u03b1 \u03bd\u03b1 \u03b5\u03bb\u03ad\u03b3\u03be\u03b5\u03c4\u03b5 \u03c4\u03b7 \u03b4\u03b9\u03b1\u03b8\u03b5\u03c3\u03b9\u03bc\u03cc\u03c4\u03b7\u03c4\u03b1 \u03ba\u03b1\u03b9 \u03bd\u03b1 \u03ba\u03ac\u03bd\u03b5\u03c4\u03b5 \u03c4\u03b7\u03bd \u03c0\u03b1\u03c1\u03b1\u03b3\u03b3\u03b5\u03bb\u03af\u03b1 \u03c3\u03b1\u03c2 \u03c3\u03ae\u03bc\u03b5\u03c1\u03b1.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/cellpeptides.com\/el\/product\/buy-tesamorelin-5mg\/","og_locale":"el_GR","og_type":"article","og_title":"Buy FOXO4-DRI 2mg (99% Purity) - CellPeptides","og_description":"Buy FOXO4-DRI for senescence and longevity research, 99% purity, HPLC-tested. Click here to check availability and order today.","og_url":"https:\/\/cellpeptides.com\/el\/product\/buy-tesamorelin-5mg\/","og_site_name":"CellPeptides","article_modified_time":"2026-08-12T10:25:58+00:00","og_image":[{"width":1200,"height":1200,"url":"https:\/\/cellpeptides.com\/wp-content\/uploads\/2026\/08\/FOXO4-DRI-2mg_mockup.png","type":"image\/png"}],"twitter_card":"summary_large_image","twitter_misc":{"\u0395\u03ba\u03c4\u03b9\u03bc\u03ce\u03bc\u03b5\u03bd\u03bf\u03c2 \u03c7\u03c1\u03cc\u03bd\u03bf\u03c2 \u03b1\u03bd\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7\u03c2":"10 \u03bb\u03b5\u03c0\u03c4\u03ac"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/cellpeptides.com\/product\/buy-foxo4-dri-2mg\/","url":"https:\/\/cellpeptides.com\/product\/buy-tesamorelin-5mg\/","name":"\u0391\u03b3\u03bf\u03c1\u03ac\u03c3\u03c4\u03b5 FOXO4-DRI 2 mg (\u03ba\u03b1\u03b8\u03b1\u03c1\u03cc\u03c4\u03b7\u03c4\u03b1 99%) - CellPeptides","isPartOf":{"@id":"https:\/\/cellpeptides.com\/#website"},"primaryImageOfPage":{"@id":"https:\/\/cellpeptides.com\/product\/buy-tesamorelin-5mg\/#primaryimage"},"image":{"@id":"https:\/\/cellpeptides.com\/product\/buy-tesamorelin-5mg\/#primaryimage"},"thumbnailUrl":"https:\/\/cellpeptides.com\/wp-content\/uploads\/2026\/08\/FOXO4-DRI-2mg_mockup.png","datePublished":"2026-08-12T10:09:36+00:00","dateModified":"2026-08-12T10:25:58+00:00","description":"\u0391\u03b3\u03bf\u03c1\u03ac\u03c3\u03c4\u03b5 FOXO4-DRI \u03b3\u03b9\u03b1 \u03ad\u03c1\u03b5\u03c5\u03bd\u03b1 \u03c3\u03c7\u03b5\u03c4\u03b9\u03ba\u03ac \u03bc\u03b5 \u03c4\u03b7 \u03b3\u03ae\u03c1\u03b1\u03bd\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03c4\u03b7 \u03bc\u03b1\u03ba\u03c1\u03bf\u03b6\u03c9\u03af\u03b1, \u03ba\u03b1\u03b8\u03b1\u03c1\u03cc\u03c4\u03b7\u03c4\u03b1 99%, \u03b5\u03bb\u03b5\u03b3\u03bc\u03ad\u03bd\u03bf \u03bc\u03b5 HPLC. \u039a\u03ac\u03bd\u03c4\u03b5 \u03ba\u03bb\u03b9\u03ba \u03b5\u03b4\u03ce \u03b3\u03b9\u03b1 \u03bd\u03b1 \u03b5\u03bb\u03ad\u03b3\u03be\u03b5\u03c4\u03b5 \u03c4\u03b7 \u03b4\u03b9\u03b1\u03b8\u03b5\u03c3\u03b9\u03bc\u03cc\u03c4\u03b7\u03c4\u03b1 \u03ba\u03b1\u03b9 \u03bd\u03b1 \u03ba\u03ac\u03bd\u03b5\u03c4\u03b5 \u03c4\u03b7\u03bd \u03c0\u03b1\u03c1\u03b1\u03b3\u03b3\u03b5\u03bb\u03af\u03b1 \u03c3\u03b1\u03c2 \u03c3\u03ae\u03bc\u03b5\u03c1\u03b1.","breadcrumb":{"@id":"https:\/\/cellpeptides.com\/product\/buy-tesamorelin-5mg\/#breadcrumb"},"inLanguage":"el","potentialAction":[{"@type":"ReadAction","target":["https:\/\/cellpeptides.com\/product\/buy-tesamorelin-5mg\/"]}]},{"@type":"ImageObject","inLanguage":"el","@id":"https:\/\/cellpeptides.com\/product\/buy-tesamorelin-5mg\/#primaryimage","url":"https:\/\/cellpeptides.com\/wp-content\/uploads\/2026\/08\/FOXO4-DRI-2mg_mockup.png","contentUrl":"https:\/\/cellpeptides.com\/wp-content\/uploads\/2026\/08\/FOXO4-DRI-2mg_mockup.png","width":1200,"height":1200,"caption":"FOXO4-DRI 2mg_mockup"},{"@type":"BreadcrumbList","@id":"https:\/\/cellpeptides.com\/product\/buy-tesamorelin-5mg\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/cellpeptides.com\/"},{"@type":"ListItem","position":2,"name":"Shop","item":"https:\/\/cellpeptides.com\/shop\/"},{"@type":"ListItem","position":3,"name":"FOXO4-DRI 2mg"}]},{"@type":"WebSite","@id":"https:\/\/cellpeptides.com\/#website","url":"https:\/\/cellpeptides.com\/","name":"\u039a\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03ac \u03a0\u03b5\u03c0\u03c4\u03af\u03b4\u03b9\u03b1","description":"","publisher":{"@id":"https:\/\/cellpeptides.com\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/cellpeptides.com\/?s={search_term_string}"},"query-input":"required name=search_term_string"}],"inLanguage":"el"},{"@type":"Organization","@id":"https:\/\/cellpeptides.com\/#organization","name":"\u039a\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03ac \u03a0\u03b5\u03c0\u03c4\u03af\u03b4\u03b9\u03b1","url":"https:\/\/cellpeptides.com\/","logo":{"@type":"ImageObject","inLanguage":"el","@id":"https:\/\/cellpeptides.com\/#\/schema\/logo\/image\/","url":"https:\/\/cellpeptides.com\/wp-content\/uploads\/2025\/02\/CellPeptides-logo2-lc2.png","contentUrl":"https:\/\/cellpeptides.com\/wp-content\/uploads\/2025\/02\/CellPeptides-logo2-lc2.png","width":697,"height":152,"caption":"CellPeptides"},"image":{"@id":"https:\/\/cellpeptides.com\/#\/schema\/logo\/image\/"}}]}},"_links":{"self":[{"href":"https:\/\/cellpeptides.com\/el\/wp-json\/wp\/v2\/product\/15058","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cellpeptides.com\/el\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/cellpeptides.com\/el\/wp-json\/wp\/v2\/types\/product"}],"version-history":[{"count":0,"href":"https:\/\/cellpeptides.com\/el\/wp-json\/wp\/v2\/product\/15058\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cellpeptides.com\/el\/wp-json\/wp\/v2\/media\/15060"}],"wp:attachment":[{"href":"https:\/\/cellpeptides.com\/el\/wp-json\/wp\/v2\/media?parent=15058"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/cellpeptides.com\/el\/wp-json\/wp\/v2\/product_brand?post=15058"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/cellpeptides.com\/el\/wp-json\/wp\/v2\/product_cat?post=15058"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/cellpeptides.com\/el\/wp-json\/wp\/v2\/product_tag?post=15058"}],"curies":[{"name":"\u03ba\u03b1\u03bb\u03cc \u03c0\u03b1\u03b9\u03c7\u03bd\u03af\u03b4\u03b9","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}